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Compliance. See Table 23-4 for a list of the ingredients of antihypertensive combination products. Patients with stage 2 hypertension may require more aggressive therapy with a second or third agent added if control is not achieved by monotherapy in a relatively short time. Patients with an average diastolic blood pressure of greater than 120 mm Hg require immediate therapy and, if significant organ damage is present, may require hospitalization for initial control. Patients who have modified their lifestyles with appropriate exercise, diet, weight reduction, and control of hypertension for at least 1 year may be candidates for "step-down" therapy. The dosage of antihypertensive medications may be gradually reduced in a slow, deliberate manner. Most patients may still require some therapy, but occasionally, the medicine can be discontinued. 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DEFINITION Invasive group A streptococcal GAS ; disease is a severe and sometimes life -threatening infection in which the bacteria have invaded various parts of the body, such as the blood, the cerebrospinal fluid, deep muscle and fat tissue, or the lungs. Invasive GAS infections may manifest as any of several clinical syndromes, including pneumonia, bacteremia in association with cutaneous infection e.g., cellulitis, erysipelas or infection of a surgical or non-surgical wound ; , deep soft-tissue infection e.g., myositis or necrotizing fasciitis ; , meningitis, peritonitis, osteomyelitis, septic arthritis, postpartum sepsis i.e., puerperal fever ; , neonatal sepsis or nonfocal bacteremia. Two of the most severe, but least common, forms of invasive GAS disease are necrotizing fasciitis infection of muscle and fat tissue ; and streptococcal toxic shock syndrome STSS ; . Approximately 20% of patients with necrotizing fasciitis and 60% with STSS die. Only about 10% to 15% of patients with other forms of invasive GAS disease die. CAUSE Group A Streptococcus. Risk factors Although anyone can get GAS disease including STSS ; , people with underlying health problems such as diabetes mellitus, chronic heart, lung or kidney problems, cancer or HIV infection are at greater risk for invasive GAS disease. A break in the skin, such as a cut or surgical wound, or chickenpox may increase a person's risk. Close contacts of a case family or household members, healthcare providers, nursing home staff ; may be at increased risk for infection because of direct contact with secretions from the infected person. Aleve naproxen ; Allegra foxofenadine ; Allerdryl dyphenhydramine ; alitretinoin: Antineoplastic. Tx: Topical treatment for cutaneous AIDS-related Kaposi's sarcoma. Alloprin allopurinol ; allopurinol : Antigout Almocarpine pocarpine ; Alphagan brimonidine ; alprazolam: Antianxiety, sedative hypnotic chem class: benzodiazepine alprostadil: Prostaglandin. Tx: Erectile dysfunction Altace ramipril ; Altinac tretinoin ; Alupent metaproterenol ; Alurate aprobarbitol ; Alvosulfon glimepiride ; Alzapam lorazepam ; amantadine: Antiviral, anti-Parkinsonism, antidyskinetic. Tx: resp tract infection, Influenza type A, symptoms of Parkinson's disease, fatigue associated with multiple sclorosis Ammaryl glimepiride ; Amatine midrodine ; Ambenyl codein + bromodiphenhydramine ; Ambien zolpidem ; Amcill ampicillin ; Amen medroxyprogesterone ; Amersol ibuprofen ; Amesec ephedrine + aminophylline ; amikacin: Antibiotic Tx: serious infections Amikin amikacin ; amiloride: Potassium sparing diuretic, anti-hypertensive Note: Amiloride is recognised as a potential cause of hyperkalemia aminolevulinic acid: Photosensitizing agent. Tx: Topical solution for actinic keratosis pre-cancerous skin growths ; . Aminophyllin aminophylline ; aminophylline: Bronchodilator Tx: asthma, bronchospasm associated with COPD Toxicology drug to drug interactions: Xanthenes decreases the efficacy of Adenosine and Diazepam higher doses may therefore be required ; amiodarone: Class III antiarrhythmic, non-competitive and adrenergic inhibition has properties of all Classes of antiarrhythmic ; Amitril amitriptyline ; amitriptyline: Tricyclic antidepressant amlexanox: Tx: Canker sores of the mouth. amlodipine: Calcium Channel Blocker, Antianginal, Antihypertensive and ambien. Table 4.9. Echinococcus multilocularis in central Europe: examples of prevalence in red foxes Diagnosis at necropsy N ; if not otherwise indicated PCR diagnosis by DNA detection Regions and countries Belgium Flanders Luxembourg Province The Netherlands Luxembourg France Lorraine Doubs Germany North and East Schleswig-Holstein Mecklenburg-Vorpommern Brandenburg Sachsen-Anhalt Saxony North-West Lower Saxony North-Rhine Westfalia Central Hesse Thuringia South-West and South Rhineland-Palatinate Saarland Baden-Wrttemberg Bavaria Switzerland 21 26 cantons ; c ; Liechtenstein Austria 5 9 federal states ; c ; Czech Republic 5 regions ; c ; Slovak Republic Eastern and western parts Poland 18 43 districts c ; Period Foxes examined infected a.
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LINE EXTENSIONS MITIGATE CNS GENERIC COMPETITION This was the first quarter of significant generic competition to Wellbutrin SR. Sales of Wellbutrin IR SR declined 76% to 51 million. However this impact was partly offset by GSK's supply agreement with Watson Pharmaceuticals which contributed 25 million ; and by the very strong performance of Wellbutrin XL, our new once-daily product, which continues to gain market share and achieved sales of 117 million. In total, sales of all Wellbutrin products were 193 million, a decline of only 7%. Generic competition in the USA, Europe and Canada continues to impact sales of Paxil IR, which declined 64% in the quarter to 151 million. This was partly offset by GSK's supply agreement with Par Pharmaceuticals which contributed 38 million and the strong performance of Paxil CR which generated sales of 95 million + 21% ; . In the USA, Paxil CR has continued to maintain its market share since the launch in September 2003 of generic immediate-release paroxetine products. Overall, sales of the total Paxil franchise were down 41% to 284 million. PIPELINE UPDATE New product launches Vesicare for overactive bladder, which GSK will co-promote with Yamanouchi Pharma America, is expected to launch later this year. In clinical trials, Vesicare once-daily was effective in improving all the symptoms of over-active bladder and was associated with a low incidence of dry mouth. Rotarix, a new vaccine for the prevention of rotavirus gastroenteritis in infants, has been filed in several Latin American markets and received its first approval in Mexico in July. The Avandia franchise is set to benefit from the addition of a new, fixed-dose combination treatment called Avandaryl, which is also expected to be launched in the second half of the year. This convenient once-daily medication combines Avandia with Aventis' Amaryl, a market leading sulphonylurea. Epivir Ziagen, expected to be launched in the third quarter, will be the first once-daily combination HIV treatment available in a single tablet. This new combination will offer a significant improvement in patient convenience over other treatment options.
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