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71 ; LINTEC CORPORATION [JP JP]; 23-23, Honcho, Itabashi-ku, Tokyo 173-0001 JP ; . RESEARCH INSTITUTE OF TTS TECHNOLOGY [JP JP]; 35-7, Nihonbashi Hama-cho 2-chome, Chuo-ku, Tokyo 103-0007 JP ; . TOKO PHARMACEUTICAL IND. CO., LTD. [JP JP]; 8-19, Shinden 3-chome, Adachi-ku, Tokyo 123-0865 JP ; . for all designated States except pour tous les tats dsigns sauf US ; 72, 75 ; NAKAHARA, Kaname [JP JP]; 7-3, Tsuji 7-chome, Urawa-shi, Saitama 336-0026 JP ; . SEKI, Toshinobu [JP JP]; 1204-1, Aza-Kanisawa, Oaza-Nagase, Moroyama-machi, Iruma-gun, Saitama 350-0443 JP ; . 74 ; HIRAKI, Yusuke et al. etc.; Toranomon No. 5 Mori Building, 3rd floor, 17-1, Toranomon 1-chome, Minato-ku, Tokyo 105-0001 JP ; . 81 ; JP US. 51 ; 7 A61K 9 70 11 ; 76486 21 ; PCT US00 16207 22 ; 14 Jun juin 2000 14.06.2000 ; 25 ; en 30 ; 139, 014 ; en 14 Jun juin 1999 14.06.1999 ; US 13 ; A1.
According to new US research, transplanted adult bone-marrow cells could succeed in regenerating human brain cells. As Jane Collingwood points out, this offers hope to sufferers of neurological diseases The work, by Dr Edward Scott from the University of Florida, US, and colleagues, could lead to new treatments for neurological diseases such as Parkinson's disease. The study, reported in medical journal The Lancet, examined the brain tissue of three women who had been given bone-marrow transplants from male donors as part of treatment for leukaemia. The donated cells were still present in the women's brains several years later. Further investigations will be made to see if the results can be replicated. If confirmed, this technique of encouraging cell growth will avoid the controversy of using embryo stem cells. Previously, human bone-marrow cells have produced new brain cells in mice, and regenerated cheek cells in women. But this is the first time that they have been used to produce nerve cells in humans. Dr Scott is optimistic: `This study suggests that bone marrow could be used as a therapeutic source of readily harvestable cells for the regeneration of nerve cells, potential application to various neurodegenerative diseases and traumatic central nervous system damage, ' he said, for instance, los delfines calan forcat.
Chemist could face new challenges in total synthesis. In spite of unavoidable difficulties in day-to-day laboratory operations compatibility, yields, cost, by-products, etc. ; it appears that the synthetic organic chemist has finally "arrived". While the means seem to be at our disposal to tackle almost any synthesis challenge, the requirements, the expectations, and the rigors of time constraints, etc. pose formidable problems of logistics sometimes. Having reached such heights in the construction of complex organic molecules, one must now view total synthesis with a different perspective. What then will some of the incentives and objectives be in the nineties and even beyond? Fig. 1 ; One of these areas could involve an even closer interface between biology and chemistry. Major advances have been made in molecular biology, pharmacology, and protein crystallography. Indeed, the crystal structures of an impressive number of complex enzymes have been analyzed to a reliable level of resolution ref. 7 ; . The active sites of many biologically relevant enzymes can now be "seen" through the help of computer graphics, with occluded organic molecules and covalently linked enzyme-substrate intermediates ref. 8 ; . The synthetic chemist can therefore visualize within reasonable limits, postulated interactions of various types with the biological targets electrostatic, hydrophobic, hydrophilic H-bonding, etc. ; . Through the advent of molecular modeling and modern techniques of computational chemistry, it is possible to further probe the overall structural features of an organic molecule in conjunction with its biological host ref. 9 ; . Chemical refinements, adjustments through synthesis, coupled with the above mentioned notions may now lead to a novel structure to be synthesized. If this is done on a natural product molecule at the outset, what results is a new-generation, semi-natural product with the prospects of interesting activity. Such molecules can also result from studies of structure-activity relationships, molecular modeling and other computational techniques as applied to unnatural molecules in a medicinal chemistry context ref. lo ; . Finally, it is not excluded that with the knowledge of a biological parameter regarding a specific molecule, or a class of molecules, there may emerge a totally novel target molecule to synthesize. Thus, one aspect of total synthesis for the present and the near future may involve new breeds of manmade molecules, generated through logic, intuition, and basic knowledge in combination with computer generated 3-dimensional structures. There are of course several other reasons for being involved in the total synthesis of natural and unnatural products which will not be elaborated upon here!
Calancha, an augustinian monk of lima, first wrote about the curative properties of cinchona powder in fevers and tertians as early as in 163 by 1640, the bark had already found its way into europe, thanks to the jesuit fathers hence the name 'jesuit's bark'.
Trends in the consumption of antidepressant drugs in Lithuania in 20022004 Table 2. The calculated data of antidepressant drug consumption in 2003.
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U strukturi preduzea najvei broj preduzea je u delatnosti trgovine 34, u industriji 29%, poljoprivredi 10%, u oblasti finansijskih i drugih usluga 9%, u graev inarstvu 6%, u saobraaju 5%, i ostalim oblastima 7 and clindamycin.
J. Zhao, P.D. Verhaert, A.P. Smits, S.J. Van der Locht, M. Schoondermark, R.G. Hanssen N.V. Organon, Oss, The Netherlands In the current in vitro fertilization IVF ; protocols, follicle stimulating hormone FSH ; is used to induce follicular growth which eventually results in ovulation of multiple oocytes. However, after IVF, only a limited percentage of these oocytes develop into a healthy fetus. Currently, no reliable criteria are available to evaluate oocyte quality. The present study is designed 1 ; to test the hypothesis that stimulation by high doses of exogenous FSH compromises the quality of ovulated oocytes and 2 ; to search for a molecular marker s ; which is predictive for the developmental competence of a given oocyte. Firstly, an animal model was set up to yield oocytes of `good' or `bad' quality. This was done in adult rats with normal estrous cycles. Blastocyst yield was used as the parameter for oocyte quality. In control groups, no gonadotropins were administrated to the animals which were allowed to mate with males after natural ovulation. Five days after copulation, blastocysts were collected from the uterus and their number recorded. In the test groups, rats were stimulated with recombinant FSH rFSH ; at different concentrations 2.5, 5, 10, IU kg ; to induce follicle development. Ovulation was induced by hCG. Mating and blastocyst evaluation were carried out as described for the control group. It was found that the blastocyst yield was significantly lower in rats treated with 5, 10 and 20 IU ml rFSH 5% ; , compared to the control groups 66% ; . This confirmed the hypothesis that a high dose of rFSH stimulation compromises oocyte quality. Furthermore, granulosa cells, which are long known to closely interact with their respective oocytes, were isolated from preovulatory follicles in control GC-C ; and rFSH-stimulated groups GC-S ; . These samples were subjected to genomic and proteomic analyses for potential molecular markers for oocyte quality. Using real-time quantitative reverse transcriptase polymerase chain reaction RT-PCR ; , the expression of several selected genes were compared in GC-C and in GC-S. Obvious up- and down-regulation of various genes were detected. In addition, high resolution 2-dimensional polyacrylamide gel electrophoresis 2D-PAGE ; and computerized gel image analysis were used to compare the protein profiles in GC-C and GC-S. Distinctive differences in protein profiles of GC-C and GC-S were observed. The identification of these proteins is in progress. Calan fougnerMMSE ; , the Memory Impairment Screen MIS ; , the Montreal Cognitive Assessment MoCA ; , the Correspondence Analysis of the Consortium to Establish a Registry for Alzheimer's Disease Word List CA-CWL ; , the MiniCog, and the Clock Drawing Test CDT ; Table 1 ; .9-13 A brief description of these screening tools follows. MMSE. The MMSE is a brief, structured assessment tool widely used in the office setting for quantifying subjective impressions of cognitive impairment.9 The MMSE is an 11-item test and focuses only on the cognitive aspects of mental function. It consists of 6 sections and evaluates orientation, memory, attention, ability to recall, language and comprehension, and praxis. Administration takes about 10 to 15 minutes and scores range from 0 to 30, with higher scores indicating better cognition. Generally, MMSE scores greater than 20 points are consistent with either normal cognition or mild dementia, MMSE scores of 10 to points are consistent with moderate dementia, and MMSE scores of 0 to are consistent with severe dementia.4 Because of the large overlap between normality and mild dementia in scores greater than 20, the MMSE does not have the ability to differentiate between these 2 cognitive states, limiting its usefulness as a screening tool in family practice. It is, however, an excellent tool in identifying more advanced states of cognitive impairment. The MMSE scores must be interpreted using norms related to age and education.14 In a series of community surveys, population-based norms for different ages demonstrated an inverse relationship between MMSE scores and age, ranging from a median score of 29 for those 18 to 24 years of age, to a median score of 25 for individuals 80 years of age or older. In addition, a direct relationship was found between MMSE scores and educational level, ranging from a median MMSE score of 29 for individuals with at least 9 years of schooling, 26 for those with 5 to 8 years of schooling, and 22 for those with 0 to 4 years of schooling.14 These factors combine to make it less sensitive for patients scoring in the lower range, such as patients in the more advanced stages of dementia, less educated patients, and, because the MMSE is language based, less sensitive for patients with severe language problems resulting from dementia or other medical conditions. The MMSE is also less sensitive among patients scoring in the upper range, such as patients who are better educated and can compensate for early deficiencies in cognition. MIS. The MIS is a 4-minute, 4-item, delayed, free- and. Cost of drugs in outpatient care during 2002, procedures adopted for dealing with surpluses or deficits, various types of reward systems, prescription monitoring, and other kinds of support to prescribers. In order to elucidate the county councils' construction of and experiences with reward systems, interviews were then conducted with project managers, heads of units, and prescribers in seven councils that have actually operated such systems. In 2002, slightly more than half of the county councils in Sweden had retained central responsibility for costs. Many of them had drafted shadow budgets with no responsibility for coping with any surpluses or deficits. Nine county councils had either decentralised a primary-care-based responsibility for costs or given individual units responsibility for the cost of the unit's own prescriptions. "Decentralised responsibility for costs" means that responsibility should either be designed as a "drugs budget" or as a "total healthcare budget". Primary-care-based responsibility for costs is the commoner model of the two. With such a scheme, primary-care or outpatient services are responsible for general pharmaceuticals and hospitals for special or clinically administered drugs. The level set for the relevant responsibility for costs varies from one healthcare unit centre or clinic ; to another and from one healthcare district to another as well. All county councils run regular checks on the development of costs within the framework of the government grant, looking at both individual drugs and pharmaceutical groups. One characteristic feature in councils with decentralised responsibility for costs is that most of them have drafted, and monitor, quality criteria in the form of recommended volumes of particular drugs or groups of pharmaceuticals. Councils with primary-carebased responsibility for costs seem to implement more types of follow-up measures than other councils. All county councils offer different kinds of support measures to prescribers. The commonest ones are the formulary committee's list of recommended preparations, prescription statist ihe, for instance, paradise club apartments calan bosch.
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