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Anton, R. F., Moak, D. H. and Latham, P. 1995 ; The obsessive compulsive drinking scale--a self rated instrument for the quantification of thoughts about alcohol and drinking behaviour. Alcoholism: Clinical and Experimental Research 19, 9299. Berglund, M., Thelander, S. and Jonsson, E. eds ; 2003 ; Treating Alcohol and Drug Abuse. An Evidence Based Review. WILEYVCH Verlag GmbH and Co. KGaA, Weinheim. Besson, J., Aeby, F., Kasas, A. et al. 1998 ; Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism--a controlled study. Alcoholism: Clinical and Experimental Research 22, 573579. Brewer, C. 1986 ; Patterns of compliance and evasion in treatment programs that include supervised disulfiram. Alcohol and Alcoholism 21, 385388. Brewer, C. 1992 ; Controlled trials of antabuse in alcoholism-- importance of supervision and adequate dosage. Acta Psychiatrica Scandanavica 69 3 ; , 5158. Brewer, C. 1995 ; Recent developments in disulfiram treatment. Alcohol and Alcoholism 28, 385393. Chick, J., Lehert, P. and Landron, F. 2003 ; Does acamprosate improve reduction of drinking as well as aiding abstinence. Journal of Psychopharmacology 17, 397402. De Sousa, A. and De Sousa, A. 2004 ; A one-year pragmatic trial of naltrexone versus disulfiram in the treatment of alcohol dependence. Alcohol and Alcoholism 39, 528531. Foster, R. H. and McClellan, K. J. 1999 ; Acamprosate-- pharmacoeconomics and implications of therapy. Pharmacoeconomics 16, 743755. Fuller, R. K. and Gordis, E. 2004 ; Does disulfiram have a role in alcoholism treatment today? Addiction 99, 2124. Lesch, O. M., Riegler, A., Gutierrez, K. et al. 2001 ; The European acamprosate trials--conclusions for research and therapy. Journal of Biomedical Sciences 8, 8995. Mann, K., Lehert, P. and Morgan, M. Y. 2004 ; The efficacy of acamprosate in the maintenance of abstinence of alcohol dependence.
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Campbell NC, Thain J, Deans HG, Ritchie LD, Rawles JM. Secondary prevention in coronary heart disease: baseline survey of provision in general practice. BMJ 1998; 316: 1430-4. Hulscher MEJL, Drenth BB van, Mokkink HGA, Wouden JC van der, Grol RPTM. Barriers to preventive care in general practice: the role of organizational and attitudinal factors. Br J Gen Pract 1997; 4: 711-4. Drenth BB van, Hulscher MEJL, Mokkink HGA, Lisdonk van de EH, Wouden JC van der, Grol RPTM. Effects of outreach visits by trained nurses on cardiovascular risk-factor recording in general practice: a controlled trial. Eur J Gen Pract 1997; 3: 90-5. Campbell NC, Thain J, Deans HG, Ritchie LD, Rawles JM, Squair JL. Secondary prevention clinics for coronary heart disease: randomised trial of effect on health. BMJ 1998; 316: 1334-7. Avins AL, Browner WS. Lowering risk without lowering cholesterol: Implications for national cholesterol policy. Ann Intern Med 1996; 125: 502-6. Lynch JW, Kaplan GA, Cohen RD, Tuomilehto J, Salonen JT. Do cardiovascular risk factors explain the relation between socioeconomic status, risk of all cause mortality, cardiovascular mortality, and acute myocardial infarction? J Epidemiol 1996; 144: 934-42. Wensing M, Weijden T van der, Grol R. Implementing guidelines and innovations in general practice: which interventions are effective? Br J Gen Pract 1998; 48: 991-7. Grol R. Personal paper. Beliefs and evidence in changing clinical practice. BMJ 1997; 315: 418-21.
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References 1. Fauser B. Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome. The Rotterdam ESHRE ASRM sponsored PCOS consensus workshop group. Hum Reprod 2004; 19: 41-47. Balen AH, Laven JSE, Tan SL, Dewailly D. The ultrasound assessment of the polycystic ovary: international consensus definiton. Hum Reprod Update 2003; 9: 505-14. Adams J, Polson SW, Abdul Wahid N, Morris DV, Frank S et al. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotrophin releasing hormone. Lancet 1985; 1375-79. 4. Clayton RN, Ogden V, Hodkinson J et al. How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? Clin Endocrinol 1999; 51: 779-86. MacDougall MJ, Tan SL, Balen AH, Jacobs HS. A controlled study comparing patients with and without polycystic ovaries undergoing in vitro fertilization. Hum Reprod 1993; 8: 233-37. Eden JA, Place J, Carter GD et al. The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. Obstet Gynecol 1989; 73: 187. Rogers PAW, Hosie MJ, Ortis A et al. Uterine glandular area during the menstrual cycle and the effects of different in-vitro fertilization related hormonal treatments. Hum Reprod 1996; 11: 376. Lersey BA, I-tein Y, Castelbaum AJ et al. Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation. Fertil Steril 1996; 65: 477. Steer CV, Tan SL, Mason BA, Campbell S. Midluteal phase vaginal color doppler assessment of uterine artery impedance in a subfertile population. Fertil Steril 1994; 61: 53-58. Nakamura Y, Sugino N, Ono M et al. Effects of clomiphene citrate on the endometrial thickness and echogenic pattern of the endometrium. Fertil Steril 1997; 67: 256-60. Ben Ami M, Geslevich Y, Matilsky M. et al. Exogenous estrogen therapy concurrent with clomiphene citrate-lack of effect on serum sex hormone levels and endometrial thickness. Gynecol Obstet Invest 1994; 37: 180-182. Yagel S, Zachut D, Ben-Chetrit A. et al. The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate. Fertil Steril 1992; 57: 33-36. Gerli S, Gholami H, Manna A et al. Use of ethinyl estradiol to reverse the antiestrogenic effects of clomiphene citrate in patients undergoing intrauterine insemination: a comparative, randomized study. Fertil. Steril. 2000; 73: 85-89. Shimoya K, Tomiyama T, Hashimoto K et al. Endometrial development was improved by transdermal estradiol in patients treated with clomiphene citrate. Gynecol Obstet Investigation 1999; 47: 251-54. Khanna SB, Khanna SD, Kohli N. Ovulation induction in polycystic ovarian disease. Presented at the Sixth International Congress on Assisted Reproduction Technology and Advances in Infertility Management, 2000; New Delhi, India. 145. THERAPHARMA P.D CHEMICAL V.S. PHARM V.S. PHARM GPO GPO L.B.S LAB L.B.S LAB and mebeverine.

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R, Reaven GM: Hyperinsulinemia in a normal population as a predictor of noninsulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited. Metabolism 48: 989 994, Legro RS, Kunselman AR, Dodson WC, Dunaif A: Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84: 165169, 1999 Palmert MR, Gordon CM, Kartashov AI, Legro RS, Emans SJ, Dunaif A: Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. J Clin Endocrinol Metab 87: 10171023, 2002 Coviello AD, Legro RS, Dunaif A: Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J Clin Endocrinol Metab 91: 492 497, Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R: The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab 81: 3299 3306, Azziz R, Ehrmann D, Legro RS, Whitcomb RW, Hanley R, Fereshetian AG, O'Keefe M, Ghazzi MN; PCOS Troglitazone Study Group: Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. J Clin Endocrinol Metab 86: 1626 1632, McCartney CR, Prendergast KA, Chhabra S, Eagleson CA, Yoo R, Chang RJ, Foster CM, Marshall JC: The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab 91: 1714 1722, Ehrmann DA, Liljenquist DR, Kasza K, Azziz R, Legro RS, Ghazzi MN; PCOS Troglitazone Study Group: Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 91: 48 53, Moghetti P, Tosi F, Castello R, Magnani CM, Negri C, Brun E, Furlani L, Caputo M, Muggeo M: The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women. J Clin Endocrinol Metab 81: 952960, 1996 Gambineri A, Pelusi C, Genghini S, Morselli-Labate AM, Cacciari M, Pagotto U, Pasquali R: Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome. Clin Endocrinol Oxf ; 60: 241249, 2004 Legro RS, Bentley-Lewis R, Driscoll D, Wang SC, Dunaif A: Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity. J Clin Endocrinol Metab 87: 2128 2133, Legro RS, Kunselman AR, Demers L, Wang SC, Bentley-Lewis R, Dunaif A: Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome. J Clin Endocrinol Metab 87: 2134 2138, Urbanek M, Woodroffe A, Ewens KG, Diamanti-Kandarakis E, Legro RS, Strauss JF 3rd, Dunaif A, Spielman RS: Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2. J Clin Endocrinol Metab 90: 6623 6629, Dunaif A, Segal KR, Futterweit W, Dobrjansky A: Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38: 11651174, 1989 Legro RS: Polycystic ovary syndrome: phenotype to genotype. Endocrinol Metab Clin North 28: 379 396, Solomon CG, Hu FB, Dunaif A, Rich-Edwards J, Willett WC, Hunter DJ, Colditz GA, Speizer FE, Manson JE: Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus. JAMA 286: 24212426, 2001 Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM; Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393 403, Apridonidze T, Essah PA, Iuorno MJ, Nestler JE: Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 90: 1929 1935, Baillargeon JP, McClish DK, Essah PA, Nestler JE: Association between the current use of low-dose oral contraceptives and cardiovascular arterial disease: a meta-analysis. J Clin Endocrinol Metab 90: 38633870, 2005 Palomba S, Orio F Jr, Nardo LG, Falbo A, Russo T, Corea D, Doldo P, Lombardi G, Tolino A, Colao A, Zullo F: Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: a prospective parallel randomized double-blind placebo-controlled trial. J Clin Endocrinol Metab 89: 4801 4809, Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348: 16251638, 2003 King MC, Marks JH, Mandell JB; New York Breast Cancer Study Group: Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 302: 643 646, Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA: Physical activity and survival after breast cancer diagnosis. JAMA 293: 2479 2486, Bowker SL, Majumdar SR, Veugelers P, Johnson JA: Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254 258 and coreg and clomiphene.
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