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1 Murphy, MP. 2000 ; Current pharmacogenomic approaches to drug development. Pharmacogenomics 1 2 ; , 115123. 2 Mancinelli, L, Cronin, M, & Sadee, W. 2000 ; Pharmacogenomics: the promise of personalized medicine. AAPS Pharmsci: 2 1 ; , article 4 : pharmsci ; . 3 Lichter, JB, & Kurth, JH. 1997 ; The impact of pharmacogenetics on the future of healthcare. Curr Opin Biotechnol 8 6 ; , 692-695. 4 Bhandari, M, Garg, R, Glassman, R, & Ma, P. 1999 ; The pharmacogenomics challenge: the only option is how and when you participate. In Vivo 17 3 ; , 36-41. 5 Spear, B. 1999 ; Viewpointpharmacogenomics: today, tomorrow, and beyond. Drug Benefit Trends 11 2 ; , 53-54. 6 Evans, WE, & Relling, MV. 1999 ; Pharmacogenetics: translating functional genomics into rational therapeutics. Science 286, 487-491. 7 Sachse, C, Brockmller, J, Bauer, S, & Roots, I. 1997 ; Cytochrome P450 2D6 variant in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 60, 284-295. 8 Ueda, S, Meredith, PA, Morton, JJ, et al. 1998 ; ACE I D ; genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug enalaprilat ; in humans. Circulation 98, 21482153. 9 Smeraldi, E, Zanardi, R, Benedetti, F, Di Bella, D, Perez, J, & Catalano, M. 1998 ; Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiat. 3, 508-511. Continued on page ?? and grisactin. IMPOSSIBLE CHOICES: Food and Housing or Prescription Drugs?. Since any psychoactive drug may impair judgment, thinking or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain the nefazodone therapy does not adversely affect their ability to engage in such activities and griseofulvin. 53. Preskorn, SH. Clinical Pharmacology of SSRI's, 1st ed. 1996, preskorn . Accessed August 2004 54. Bordet R, Thomas P, Dupuis B. Effect of pindolol on onset of action of paroxetine in the treatment of major depression: intermediate analysis of a double-blind, placebo-controlled trial. Reseau de Recherche et d'Experimentation Psychopharmacologique. J Psychiatry. 1998; 155: 1346-51. Rickels K, Schweizer E. Clinical overview of serotonin reuptake inhibitors. J Clin Psychiatry. 1990; 51 Suppl B: 9-12. 56. Brosen K, Rasmussen BB. Chapter 4 Selective Serotonin Re-uptake Inhibitors: Pharmacokinetics and Drug Interactions. In: Selective Serotonin Re-uptake Inhibitors, 2nd ed., Advances in Basic Research and Clinical Practice. Volume 5. Eds. Feighner, JP, Boyer, W.R., 1996 57. Sommi RW, Crismon ML, Bowden CL. Fluoxetine: a serotonin-specific, second-generation antidepressant. Pharmacotherapy. 1987; 7: 1-15. Ronfeld RA, Tremaine LM, Wilner KD. Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers. Clin Pharmacokinet. 1997; 32 Suppl 1: 22-30. 59. Perucca E, Gatti G, Spina E. Clinical pharmacokinetics of fluvoxamine. Clin Pharmacokinet. 1994; 27: 175-90. Hotopf M, Hardy R, Lewis G. Discontinuation rates of SSRIs and tricyclic antidepressants: a metaanalysis and investigation of heterogeneity. Br J Psychiatry. 1997; 170: 120-7. Hyttel J. Pharmacological characterization of selective serotonin reuptake inhibitors SSRIs ; . Int Clin Psychopharmacol. 1994; 9 Suppl 1: 19-26; Sanchez C, Hyttel J., Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol. 1999; 19: 467-89. Fisher S, Kent TA, Bryant SG. Postmarketing surveillance by patient self-monitoring: preliminary data for sertraline versus fluoxetine. J Clin Psychiatry. 1995; 56: 288-96. Rosenberg KP. Sildenafil citrate for SSRI-induced sexual side effects. J Psychiatry. 1999; 156: 157. Gupta S, Droney T, Masand P, Ashton AK. SSRI-induced sexual dysfunction treated with sildenafil. Depress Anxiety. 1999; 9: 180-2 Ciraulo DA, Shader RI. Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics. J Clin Psychopharmacol. 1990; 10: 48-50. DeVane CL. Pharmacokinetics of the newer antidepressants: clinical relevance. J Med. 1994; 97: 13S-23S. Olivier, B, Soudjin, W., vanWijngaarden, I. Serotonin, dopamine, and norepinephrine transporters in the CNS and their inhibitors, In: Progress in Drug Research. Vol. 54. E. Jucker, Ed., Birkhuser Verlag, Basel Switzerland ; , 2000. 68. Wong DT, Threlkeld PG, Robertson DW. Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors. Neuropsychopharmacology. 1991; 5: 43-7. Wong DT, Bymaster FP, Reid LR, Mayle DA, Krushinski JH, Robertson DW. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology. 1993; 8: 337-44.

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Evaluation of the electrocardiograms for patients with depression or ocd who participated in premarketing studies revealed no differences between cluvoxamine and placebo in the emergence of clinically important ecg changes and gabapentin and fluvoxamine. Endocrine, Metabolic & Immune Disorders - Drug Targets, 2007, Vol. 7, No. 1 61 Lovett-Racke, A.E.; Hussain, R.Z.; Northrop, S.; Choy, J.; Rocchini, A.; Matthes, L.; Chavis, J.A.; Diab, A.; Drew, P.D. and Racke, M.K. 2004 ; J. Immunol., 172 9 ; , 5790-5798. [287] Klotz, L.; Schmidt, M.; Giese, T.; Sastre, M.; Knolle, P.; Klockgether, T. and Heneka, M.T. 2005 ; J. Immunol., 175 8 ; , 49484955. [288] Pershadsingh, H.A. 2004 ; Expert Opin. Investig. Drugs, 13 3 ; , 215-228. [289] Miller, D.H. 2005 ; Mult. Scler., 1 ; , 164. [290] Brinkmann, V.; Davis, M.D.; Heise, C.E.; Albert, R.; Cottens, S.; Hof, R.; Bruns, C.; Prieschl, E.; Baumruker, T.; Hiestand, P.; Foster, C.A.; Zollinger, M. and Lynch, K.R. 2002 ; J. Biol. 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[304] Menge, T.; Hartung, H.P. and Stuve, O. 2005 ; Nat. Rev. Neurosci., 6 4 ; , 325-331. [305] Youssef, S.; Stuve, O.; Patarroyo, J.C.; Ruiz, P.J.; Radosevich, J.L.; Hur, E.M.; Bravo, M.; Mitchell, D.J.; Sobel, R.A.; Steinman, L. and Zamvil, S.S. 2002 ; Nature, 420 6911 ; , 78-84. [306] Aktas, O.; Waiczies, S.; Smorodchenko, A.; Dorr, J.; Seeger, B.; Prozorovski, T.; Sallach, S.; Endres, M.; Brocke, S.; Nitsch, R. and Zipp, F. 2003 ; J. Exp. Med., 197 6 ; , 725-733. [307] Paintlia, A.S.; Paintlia, M.K.; Khan, M.; Vollmer, T.; Singh, A.K. and Singh, I. 2005 ; FASEB J., 19 11 ; , 1407-1421. [308] Rizvi, S.A. and Bashir, K. 2004 ; Neurology, 63 12 ; , 47-54. [309] Weber, M.S.; Prod'homme, T.; Steinman, L. and Zamvil, S.S. 2005 ; Nat. Clin. Pract. Neurol., 1, 106-112. [310] Dunn, S.E.; Youssef, S.; Goldstein, M.J.; Prod'homme, T.; Weber, M.S.; Zamvil, S.S. and Steinman, L. 2006 ; J. Exp. Med., 203 2 ; , 401-412. [311] Vollmer, T.; Key, L.; Durkalski, V.; Tyor, W.; Corboy, J.; Markovic-Plese, S.; Preiningerova, J.; Rizzo, M. and Singh, I. 2004 ; Lancet, 363 9421 ; , 1607-1608. [312] Stuve, O.; Youssef, S.; Weber, M.S.; Nessler, S.; von Budingen, H.C.; Hemmer, B.; Prod'homme, T.; Sobel, R.A.; Steinman, L. and Zamvil, S.S. 2006 ; J. Clin. Invest., 116 4 ; , 1037-1044. [313] Neuhaus, O.; Strasser-Fuchs, S.; Fazekas, F.; Kieseier, B.C.; Niederwieser, G.; Hartung, H.P. and Archelos, J.J. 2002 ; Neurology, 59 7 ; , 990-997. [314] Birnbaum, G. and Altafullah, I. 2005 ; Neurology, 64 6 ; , 306.158. [286]. Reprints: P. Sriramarao, Division of Vascular Biology, La Jolla Institute for Molecular Medicine, 4570 Executive Dr, San Diego, CA 92121; e-mail: rao ljimm . The publication costs of this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked ``advertisement'' in accordance with 18 U.S.C. section 1734. 2001 by The American Society of Hematology and gatifloxacin. Make sure you tell your doctor if you have any other medical problems, especially: brain disease or mental retardation or seizures, history of— the risk of seizures may be increased liver disease— higher blood levels of flhvoxamine may occur, increasing the chance of side effects mania or hypomania, history of— the condition may be activated back to top proper use take this medicine only as directed by your doctor to benefit your condition as much as possible. 8 88-5 89 Graduate Teaching Assistant, Department of Psychology, University of North Dakota. Grand Forks, ND. Part-time position. Duties: Instructed undergraduate students in Statistics 1988 ; and Educational Psychology 1989 ; . Supervisors: Ralph Kolstoe, Ph.D., and Mark Grabe, Ph.D. 1987-88 Software Developer, Network Services Richmond, VA ; and Neuroscience Publishers. Indianapolis, IN ; . Part-time position. Duties: Created the First Mate Attention and Visual Motor Skills series Network Services ; and Public Domain I : Math and Language Skills NeuroScience Publishers ; , software used for cognitive rehabilitation and training. 1984-88 Computer Consultant, Department of Rehabilitation Medicine, Medical College of Virginia, Richmond, VA. Part-time position. Duties: Designed SAS mainframe data file and collection system for research on traumatic brain injury. 6 84-6 88 Instructor and Research Coordinator, Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University. Richmond, VA. Full-time position. Duties: Responsible for research in Psychiatry at all levels: study design, subject recruitment and screening, testing, data management and statistical analysis. Specific areas: Familial vs. Sporadic Schizophrenia Study: A pilot study of schizophrenics and their families using CT and NMR, neuropsychological testing, measures of premorbid status, amphetamine challenge, drug response and other assessments to uncover the characteristics of patients who have a weak genetic loading for schizophrenia. Investigational Drug Trials: Conducted studies of clinical efficacy per FDA regulations with Dluvoxamine antidepressant from Kali-Duphar labs ; , Etoperidone antidepressant, Smith-Kline ; , and ICI 169, 369 an anxiolytic from ICI America ; . In addition, conducted a comparative study on the absorption and long-term efficacy of Sinequan and Adapin both brands of doxepin ; . Collaboration with Rehabilitation Medicine: In association with Dr. Jeffrey Kreutzer, compared various methods of computerized cognitive rehabilitation leading to a book ; , assisted in a study on MMPI characteristics of head-injured patients, and participated in several major grants and research projects. Clinical Supervisors: Solomon Goldberg, Ph.D., Anand Pandurangi, M.D., Jeffrey Kreutzer, Ph.D. Nafazodone, fluvoxamine, cimetidine consider xanax dose reduction. 55. Orholm M, Honor, PF, Zeeberg I. A randomized general practice group-comparative study of femoxetine and placebo in the prophylaxis of migraine. Acta Neurol Scand. 1986; 74 3 ; : 235-239. 56. Zeeberg I, Orholm M, Nielsen JD, Honor, PL, Larsen JJ. Femoxetine in the prophylaxis of migraine: a randomised comparison with placebo. Acta Neurol Scand. 1981; 64 6 ; : 452-459. 57. Adly C, Straumanis J, Chesson A. Fluoxetine prophylaxis of migraine. Headache. 1992; 32 2 ; : 101-104. 58. Saper JR, Silberstein SD, Lake AE III, Winters ME. Double-blind trial of fluoxetine: chronic daily headache and migraine. Headache. 1994; 34 9 ; : 497-502. 59. Monro P, Swade C, Coppen A. Mianserin in the prophylaxis of migraine: a double-blind study. Acta Psychiatr Scand. 1985; 72 suppl 320 ; : 98-103. 60. Jacobs H. A trial of opipramol in the treatment of migraine. J Neurol Neurosurg Psychiatry. 1972; 35 4 ; : 500-504. 61. Bnk J. A comparative study of amitriptyline and fluvxamine in migraine prophylaxis. Headache. 1994; 34 8 ; : 476-478. 62. Mathew NT. Prophylaxis of migraine and mixed headache. A randomized controlled study. Headache. 1981; 21 3 ; : 105-109. 63. Andersson PG, Petersen EN. Propranolol and femoxetine, a 5HT-uptake inhibitor, in migraine prophylaxis: a double-blind crossover study. Acta Neurol Scand. 1981; 64 4 ; : 280-288. 64. Kangasniemi PJ, Nyrke T, Lang AH, Petersen E. Femoxetine--a new 5-HT uptake inhibitor--and propranolol in the prophylactic treatment of migraine. Acta Neurol Scand. 1983; 68 4 ; : 262-267. 65. Bonuso S, Di Stasio E, Barone P, Steardo L. Timed-release dihydroergotamine in the prophylaxis of mixed headache: a study versus amitriptyline. Cephalalgia. 1983; 3 suppl 1 ; : 175178. 66. Steiner TJ, Ahmed F, Findley LJ, MacGregor EA, Wilkinson M. S-fluoxetine in the prophylaxis of migraine: a phase II double-blind randomized placebo-controlled study. Cephalalgia. 1998; 18 5 ; : 283-286. 67. Ahuja GK, Verma AK. Propranolol in prophylaxis of migraine. Indian J Med Res. 1985; 82: 263-265. Brgesen SE, Nielsen JL, Mller CE. Prophylactic treatment of migraine with propranolol: a clinical trial. Acta Neurol Scand. 1974; 50 5 ; : 651-656. Antidepressant agent Sertraline solid oral form ; Amitriptyline solid oral form ; Citalopram solid oral form ; Fluoxetine solid oral form ; Paroxetine solid oral form ; Fluv9xamine solid oral form ; Mirtazapine solid oral form ; Doxepin solid oral form ; Fluoxetine liquid oral form ; Drug quantity, mg 104 483 400 Drug quantity DDD DDD 1000 inhabitants day 1.650 1.482 0.974 Price Lt ; 6 442 252 Price DDD Lt ; 3.08 0.32 3.64 and luvox.

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