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Correspondence and offprint requests to: Godfrey Clark, Department of Paediatric Nephrology, GKT Hospitals Medical and Dental Schools, Guy's Hospital, London SE1 9RT, UK. Email: godfrey.clark kcl.ac. Mission Description and Justification: This project supports research on soldier performance, including the areas of visual, auditory, cognitive, and stress-related performance. The objective is to identify, describe and manage underlying human-system interface factors critical to the design of Army weapon systems. The work in this program is consistent with the Army Science and Technology Master Plan ASTMP ; , and the Army Strategic Research Objectives SROs ; . FY 1998 Accomplishments: 2453 - Completed report on the effects of spatial separation on the detection and localization of sound signals presented in noise. Continued to explore the effects of practice and learning on human auditory performance. - Continued investigation of hyperstereopsis and its effect on visual perception and depth compression for night vision goggle resolution and field of view design guidelines. - Conducted a helmet mounted display field study examining design tradeoffs in information display format and the relative impact on soldier crosscountry navigation performance. - Continued verification and validation of the noise hazard model with hearing loss data. Delivered beta site versions to NATO Research Study Group RSG ; , Medical R&D command, and Society of Automotive Engineers SAE ; Airbag Committee. Conducted field experiment with the previously developed auditory hazard meter to determine user applications. - Published report on the effects of stress on voice recognition system efficacy. Conducted studies on the relationship between stress and complex cognitive functioning. - Published report on quantification of attentional field of view FOV ; under various divided attention conditions as a predictive measure of driving ability and navigation. Total 2453 FY 1999 Planned Program: 2229 - Complete data collection efforts on human auditory processes in detecting sound in various environments and estimating the distance from the sound source. - Publish results of previous studies examining the interaction effects of field-of-view, ocular configuration, and image resolution on task performance using night vision devices in tactical settings; develop draft set of operational metrics for measuring depth perception and visual attention. - Publish results of previous helmet-mounted display studies. Develop a model that evaluates changes in soldier performance and workload as a function of changes in display design. Project B74A Page 71 of 74 Pages 83 Exhibit R-2A PE 0601102A ; Item 2 and loestrin. 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SIR, A 27-yr-old woman was referred for evaluation of mild anaemia, leucocytosis and thrombocytosis. History revealed a diagnosis of RothmannMakai syndrome lipogranulomatosis subcutanea ; , a rare variant of WeberChristian disease, at the age of 13 yr. At that time the patient had presented with a minor fracture of the left ankle, and when the plaster was removed she was found to have irregular red discoloration on the outer part of the ankle. This subsequently spread to involve both shins. A biopsy specimen was obtained from one of the erythematous nodules. In the histopathological sections there was a moderate lymphocytic infiltration in the lobules of the panniculus and fibrocytes invading the lobules from the fibrous septae. Work-up at that time also included antinuclear antibodies ANA ; , rheumatoid factor RF ; , C-reactive protein CRP ; , anti-double-stranded DNA, anticardiolipin, anti-Scl-70 and cryoglobulins, which were all negative. A complete blood count was normal. With these findings and lack of any systemic manifestations, a diagnosis of Rothmann Makai syndrome was established. The patient received an 8-month course of steroids. The erythema resolved and the patient was left with two slightly atrophic areas in both calves. No relapse has occurred. History also revealed Hashimoto's thyroiditis diagnosed at the age of 14 yr and the onset of alopecia areata at the age of 20 yr. The patient has developed progressive increase in her leucocyte count [ 812 ; 109 l] with a normal distribution and platelet count [ 450600 ; 109 l] over the past 8 yr. When seen in our clinic she was feeling well. Except for obesity, the physical examination was unremarkable. Haemoglobin was 14 g dl with normal red cell indices, the platelet count was 668 109 l and the leucocyte count was 16.2 109 l with a normal distribution. A peripheral blood smear revealed anisopoikilocytosis and numerous HowellJolly bodies, indicating functional hyposplenism. Computed tomography revealed a small spleen and no flow signals could be derived by colour Doppler measurements from the spleen. RothmannMakai syndrome is a rare form of WeberChristian disease, usually seen in adolescent and middle-aged women [1]. Subcutaneous nodules develop during the course of the disease whereas systemic manifestations are absent. Multiple painless nodules appear throughout the muscle and subcutaneous tissues. The primary pathological process is lobular panniculitis, which passes through the same three stages as WeberChristian disease. In the first stage, there is acute inflammation of the fat lobules with fat cell degeneration accompanied by an infiltrate of neutrophils, lymphocytes and macrophages. The second stage is characterized by many foamy histiocytes, and the infiltrate is discretely localized to the fat lobules. Finally, the foam cells are replaced by fibroblasts. The first two histological stages correspond to clinically apparent induration, while in the third stage atrophy of.

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The schedules of hormone treatments after irradiation are given in Fig. 1. All the treatments were given for a period of 4 wk from wk 37 after irradiation. Experiments 1a and 1b differed by the delivery methods for MPA, resulting in different doses. The dose of MPA was selected to be between 8 and 10 mg kg d based on previous studies using injections 13, 21 ; . In experiment 1a, we implanted in each rat one 75-mg sc MPA pellet, which nominally was supposed to release 2.7 mg d, equivalent to 9 mg kg d, for 28 d with the rats we used. In experiment 1b, we gave MPA injections of 10 mg kg d in a solvent of 95% olive oil and 5% benzyl alcohol for 2 wk wk and 4 after irradiation ; , followed by 5 mg kg injections once every 2 d for 1 wk wk Because of depot accumulation of MPA, this was sufficient to keep T levels suppressed to less than 10% of control until wk 7. The GnRH-ant Acyline was dissolved in sterile water and given as weekly sc injections of 1.5 mg kg on wk 35 after irradiation followed by a reduced dose of 0.7 mg kg at wk 6. have determined that a dose of Acyline of 1.5 mg kg suppresses serum T 0.1 ng ml within 3 d of the first injection and maintains suppression for 710 d Porter, K. L., G. Shetty and M. L. Meistrich, manuscript in preparation ; . The dose of. No on the contrary, medication compliance of -agonist inhaler in intervention group was lower than in control group ; . No.

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The proportion of 7% depressed patients out of the total stroke population seems to be small in comparison to results from epidemiologic studies.1 It should, however, be kept in mind that a common limitation to depression treatment trials in stroke is that up to one half of the patients are not even primarily considered for inclusion due to communication difficulties and cognitive impairment.42 In our treatment trial, patients suffering from more severe depressions were not considered, and by intention we did not include those patients who were discharged from the acute hospital to institutionalized care. Strengths A major strength of this study is the combination of a long-term duration and a placebo-controlled design. It is to our knowledge the first randomized controlled study of poststroke depression lasting for 6 months. 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For a variety of reasons, the thyroid may begin to function improperly, secreting less of its critical hormones. When this happens, it is termed hypothyroidism. The symptoms listed at the beginning of this article can be the result. When problems develop with the thyroid gland, especially if the thyroid is overactive or severely underactive, one medical approach is to remove the thyroid gland surgically or to irradiate it, effectively "killing" the gland. When these procedures are done, replacement thyroid therapy is given. The problem is that only one synthetically produced hormone, thyroxine e.g., Synthroid, Levothroid, Levothyroxine, etc. ; is provided. There are a number of reasons why this is not a good idea. There are a "group" of thyroid hormones working in concert which are critical to life; not just one. Because of their widespread effects on the body, a lack of these hormones can have profound consequences for health and longevity. Natural Approaches To A Healthy Thyroid There are a variety of natural approaches available to promote the health of the thyroid gland, including diet, supplementation and exercise. The whole food diet should be your first line of defense in keeping your thyroid gland healthy. Eat a balanced diet consisting of plenty of fiber, fruits, vegetables dark green and yellow ; , whole grains, nuts and seeds. These groups will be highest in the vitamins and minerals the thyroid needs. Protein is important in moderation. Use both fish and poultry sources. Consume foods high in iodine which include fish, kelp and most vegetables. Eat multiple small meals every day. This is especially important if your thyroid is underactive or you are attempting to lose weight. Your metabolism will already be slowed down, which will only make these situations more difficult.

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Progestins 68: 32 ESTROGENS CHLOROTRIANISENE TACE ; DIETHYLSTILBESTROL DES ; ESTERIFIED ESTROGENS ESTRONE, ESTRATAB ; ESTRADIOL ESTROGENS, CONJUGATED PREMARIN ; ETHINYL ESTRADIOL See also: Estrogen-Progestin combinations 68: 12 68: ANTIDIABETIC AGENTS 68: 20.08 INSULINS INSULIN, LENTE HUMAN U-100 INSULIN, NPH HUMAN U-100 INSULIN, REGULAR HUMAN U-100 INSULIN, 70 30 HUMAN U-100 INSULIN, ULTRA-LENTE HUMAN U-100 68: 20.20 SULFONYLUREAS GLYBURIDE MICRONASE ; 68: 20.92 MISCELLANEOUS ANTIDIABETIC AGENTS GLUCAGON METFORMIN GLUCOPHAGE ; 68: 24 PARATHYROID CALCITONIN 68: 28 PITUITARY CORTICOTROPIN DESMOPRESSIN DDAVP ; VASOPRESSIN PITRESSIN ; 68: 32 PROGESTINS HYDROXYPROGESTERONE MEDROXYPROGESTERONE CYCRIN, PROVERA ; NORETHINDRONE ACETATE PROGESTERONE See also: Estrogen-Progestin combinations 68: 12 Megestrol 10: 00 68: 36 THYROIDS AND ANTITHYROID AGENTS 68: 36.04 THYROID AGENTS LEVOTHYROXINE LEVOTHROID ; LIOTHYRONINE CYTOMEL ; 68: 36.08 ANTITHYROID AGENTS METHIMAZOLE TAPAZOLE ; PROPYLTHIOURACIL PTU ; 68: 16 72: 00 LOCAL ANESTHETICS BUPIVACAINE MARCAINE ; BUPIVACAINE & EPINEPHRINE MARCAINE WITH EPI ; LIDOCAINE XYLOCAINE ; LIDOCAINE & EPINEPHRINE XYLOCAINE WITH EPI ; MEPIVACAINE POLOCAINE ; see also.

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