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Increase in suicide-related behaviour and hostility that have been associated with the medicines during clinical trials. Should a physician take the decision to prescribe a SSRI or SNRI for depression or anxiety in children or adolescents, the CHMP are advising careful monitoring of the patient concerned, for example, oxycodone images.
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Kalso E, Vainio A. Morphine and oxycodone hydrochloride in the management of cancer pain. Clin Pharmacol Ther 1990; 47: 639-46.
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| Generic oxycodone 80 mgOpiate Immunoassay Cross-Reactivity Compound [ug mL] Opiate 300 Opiate2000 codeine 0.3 2000 morphine 0.3 2000 dihydrocodeine 1.0 1.5 hydrocodone 1.0 3.0 hydromorphone 1.0 3.0 morphine-3-glucuronide 0.5 3.0 oxycodone * 10 6.0 oxymorphone 50 120 6-Acetyl-Morphine N A 2.5 Heroin N A 40 Effect Positive Positive Positive Positive Positive Positive Positive Positive Positive Positive and paxil.
The pharmacy must maintain this register for at least one 1 ; year. 10 24 2005.
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Oxycontin oxycodone hydrochloride controlled-release ; is an opioid analgesic in time-release form.
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Generally, a BMI between 19 and 30 is considered ideal. If the patient's BMI falls below 19 or exceeds 30, the patient is at risk for serious health complications and should consult a physician. Figure 3. Calculation of BMI.
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MEDICATION FOR BEHAVIORAL PROBLEMS When medical doctors, psychiatrists, or other medical professionals determine that a behavioral problem exists that may be addressed through medication, they usually prescribe a medication from one or both of the classes of medications listed below: 1. Schedule II Controlled Substances -- These are drugs with a high abuse risk, but also have safe and accepted medical uses in the United States. These drugs can cause severe psychological or physical dependence. Schedule II drugs include certain narcotics, stimulants, and depressant drugs. Some examples are morphine, cocaine, oxycodone Percodan ; , and dextroamphetamine Dexedrine ; . Within this classification of drugs, methylphenidate Ritalin ; is one of the most frequently prescribed medications used to treat children diagnosed with attention deficit hyperactivity disorder ADHD ; . Ritalin is a stimulant that's effect on reducing the symptoms of ADHD are well documented, but not well understood. Some researchers believe that the stimulant actually "overloads" the active parts of the brain that may contribute to ADHD, so the stimulant actually has a calming effect. Some national estimates indicate that over ten million prescriptions are written annually for Ritalin, demonstrating that the problem is widespread. However, since Ritalin is a Schedule II controlled substance, it requires a new prescription each month. When taken into account, this drops the number of persons actually using the medication at any given time down to between 1 million and 2 million persons in the United States. 2. Psychotropic Substances These medications are used to stabilize and promote the mental health of individuals. There are a wide variety of medications used for these purposes, some of which are used to reduce anxiety, depression, or even the side effects of the medications used to control the primary diagnosis of ADHD. Some of the most common medication used for these purposes include the Selective Serotonin Reuptake Inhibitors SSRIs ; e.g, Paxil, Effexor, etc. ; . Like the Schedule II controlled substances, most of the SSRIs have mild to moderate side effects. These medications have not been expressly approved by the FDA for use in non-adults. The use of these medications by children and teenagers is considered "off-label." In fact, in March 2004, the U.S. Food and Drug Administration FDA ; issued a cautionary warning to the public and medical providers regarding the use of SSRIs and other anti-depressants by children and teenagers. Most importantly, the FDA warned that there may be an increase risk of suicide among young patients using these medications. In April 2004, the British Medical Journal published a research article strongly criticizing the use of certain SSRIs by children and adolescents.1 The researchers found: The efficacy of newer antidepressants for use in childhood depression has been exaggerated. That the clinical benefits of these medications are no better than a placebo. Adverse effects have been downplayed, including an increased risk of hostility and suicide.
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Istered. This should result in the same analgesia as 50 to mg of codeine, the dose usually administered in combination with aspirin or acetaminophen. Administration of two tablets of a fixed-dose combination containing 5 mg oxycodone should result in a greater analgesia but has been demonstrated to result in adverse effects in approximately 64% of subjects receiving an oxycodone-acetaminophen combination following oral surgery Cooper et al., 1980 ; . A dose-response evaluation of 2.5, 5, and 10 mg of oxycodone in combination with 400 mg ibuprofen failed to demonstrate any additive effects for the two lower oxycodone doses Dionne, 1999 ; . The 10-mg oxycodone dose produced greater analgesia but only over the initial 2 hrs of the study, i.e., until ibuprofen reached its peak effect Fig. 6 ; . The addition of oxycodone was accompanied by a dose-related increase in side-effects with only five of 30 subjects at the 10-mg dose level not reporting a complaint. Conversely, Cooper et al. 1993 ; found a significant effect for 5 mg oxycodone plus 400 mg ibuprofen in comparison with ibuprofen alone for pain relief at later time points 4 to 6 hrs post-drug ; but also with a higher incidence of side-effects than with ibuprofen alone. The sparse data for oxycodone plus ibuprofen in the oral surgery model limit generalization regarding the potential utility of such a combination in dentistry. Administration of 5 mg oxycodone may produce additive analgesia, probably no greater than that seen for 60 mg codeine, while resulting in the usual opioid side-effects in ambulatory patients: drowsiness, nausea, and vomiting. Increasing the oxycodone dose to 10 mg will likely result in additive analgesia but with a marked increase in side-effects. The lack of an ibuprofen-plus-oxycodone combination and the regulatory restrictions placed on oxycodone when prescribed as a single entity make the clinical utility of this combination for use in dentistry questionable.
The elimination half-life of oxycodone is 3 5 hours with the duration of analgesia lasting 3 4 hours and potassium.
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Continued shortfall in the availability of diamorphine injection The national shortage of diamorphine injection will extend into 2006. In the interim morphine sulphate injection is the first choice alternative to subcutaneous diamorphine in Lothian. An updated guidance document to deal with the diamorphine shortage was issued in Lothian in June 2005. The NHS Purchasing and Supplies Agency reports that: Wockhardt CP Pharmaceuticals ; have maximised production of 5mg, 10mg and 30mg diamorphine ampoules and is releasing batches as soon as they are available. Chiron Vaccines Ltd is also manufacturing 10mg and 30mg diamorphine ampoules. Despite this, full market demand cannot be met. Chiron Vaccines Ltd no longer have a stock of 100mg and 500mg diamorphine ampoules - Wockhardt CP Pharmaceuticals ; are manufacturing 100mg and 500mg diamorphine ampoules but again full market demand cannot always be met. The morphine 10mg ml injection supply position remains robust. Lothian Palliative Care Guidelines LPCG ; The second edition of the LPCG was distributed in paper format in October 2004. This document aims to provide clear, concise, practical, clinically focused palliative care guidance that can assist the multiprofessional team in providing high quality palliative care. Patient leaflets on opioids, strong painkillers and driving, using your medicines safely and coping with symptoms are also included to improve patient information. An appendix highlighting key aspects of the guidelines is included in the Lothian Joint Formulary ljf ot.nhs ; and a web version of the guidelines is available via the South East Scotland Cancer Network scan ot.nhs ; . Specialist Palliative Care Medicines The Formulary Committee has recently classified the specialist palliative care medicine "ketamine" as an amber category - general use with restrictions within the "Policy for use of unlicensed and off-label medicines in NHS Lothian". Ketamine is an adjuvant analgesic used for patients with neuropathic pain that is poorly responsive to opioids and is initiated by a consultant in palliative medicine. Patients stabilised on ketamine may be discharged to home and treatment is continued in the community. Guidelines on the use of ketamine in specialist palliative care services are currently available and a shared care protocol is in development. Prescribing guidelines for other specialist palliative care medicines e.g. oxycodone ; are available from specialist palliative care units and teams. Key messages: Supply difficulties continue with diamorphine - the first choice injectable opioid for subcutaneous use in palliative care is now morphine sulphate injection. Levomepromazine 6mg tablets is a palliative care medicine which is stocked in the community pharmacy palliative care network. The community pharmacy palliative care network is available 24 hours a day and specialist palliative care advice can be obtained 24 hours a day via the two Edinburgh Hospices. Consult the Lothian Palliative Care Guidelines for clinical and patient focused information. Levomepromazine 6mg tablets A recent survey highlighted a problem for healthcare professionals accessing a supply of levomepromazine 6mg tablets Levinan ; . This medicine is: commonly used in palliative care for the control of nausea and vomiting a named patient medicine routinely stocked by the community pharmacy palliative care network sites. Refer to the guidance document in the LPCG for detailed information on levomepromazine 6mg tablets and for information on how to access the network community pharmacies. Pharmaceutical advice on medicines used in palliative care Advice on medicines used in palliative care is available from: Community pharmacy palliative care network pharmacists Specialist palliative care pharmacists: - Lynn Bennett, St John's Hospital, West Lothian - Helen Moulsdale, Western General Hospital, Edinburgh - Dorothy McArthur, Marie Curie Hospice and St Columba's Hospice, Edinburgh. Contact details are available in the Lothian Palliative Care Guidelines. Thanks to Dorothy McArthur, Principal Pharmacist, Marie Curie and St Columba's Hospices for contributing to this article and pravachol and oxycodone.
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Thesia, 12 they are very expensive. The anti-emetic efficacy of ranitidine, 34 an H2-receptor antagonist, has not been thoroughly addressed. Ranitidine increases the pH of gastric juice and diminishes its volume. Thus, it was decided to evaluate the influence of ranitidine on postoperative nausea and or vomiting PONV ; after hysterectomy and to compare it with droperidol which is already established as an anti-emetic, 56 and with a placebo. Methods Following ethical committee and patient oral consent, three groups of 60 Finnish patients about to undergo abdominal hysterectomy were entered into the randomized, double-blind study. The first group was given ranitidine 300 mg po on the evening prior to surgery and again on the following morning. Approximately 30 min before the end of surgery, these patients received isotonic saline 0.3 ml iv. The second group received placebo tablets on the evening before and on , the morning of surgery. About 30 min before surgery ended, droperidol 0.75 mg 0.3 ml ; was injected iv. Patients in the third group served as control; they were given placebo tablets on the evening and morning while before the operation ended, saline 0.3 ml was injected iv. On the evening before surgery, all patients received temazepam tablets 20 mg along with the randomized study drug. On the following morning, diazepam 10 mg and the study drug were given po, about one hour before the patient was taken to the operating theatre. Following glycopyrrolate 0.2 mg and alcuronium 2-3 mg, anaesthesia was induced with fentanyl 0.1 mg and thiopentone. Tracheal intubation was facilitated using succinylcholine. All drugs were injected into an intravenous infusion of Ringer's acetate solution. Anaesthesia was maintained with nitrous oxide oxygen 2: 1 ; and isoflurane 0.3-1% inspired ; . Fentanyl 0.05-0.1 mg was given as needed and alcuronium served as the muscle relaxant. Neostigmine 2 mg and glycopyrrolate 0.4 mg were given when surgery ended to antagonize the remaining neuromuscular blockade. As is standard practice in this hospital, diclofenac 75 mg was given via a slow intravenous infusion to every patient in the recovery room and repeated when she was returned to her ward. On average, 2.5 1 were infused to each patient in the form of Ringer's acetate and isotonic glucose solutions during the study period. The amount of fentanyl that each patient received was recorded. Postoperative pain was treated with oxycodkne 3-4 mg iv and 8-10 mg im respectively in the recovery room and on the ward; the total amounts being recorded. Droperidol 0.75 mg iv was used as the "rescue drug.
Tween 1996 and 1998, underscoring a recent escalation in its incidence of abuse.36 Heroin is a highly effective analgesic that is widely prescribed in the United Kingdom for control of acute and chronic pain.16 Nevertheless, heroin's notoriety and perceived liability for abuse has prohibited its clinical use in the United States. Prescribed opioids that provide a desirable "high, " that is, a rapid onset to peak effect and pleasurable feelings of sedation or euphoria, are also commonly abused. These include rapid-acting semisynthetics such as oxycodone, hydrocodone, oxymorphone, and hydromorphone and nonmorphinian synthetics including methadone and fentanyl.16, 21, 37, 38 Only a small minority of abusers prefer drugs that produce dysphoria, such as meperidine and pentazocine.16, 21 Reports of oxucodone and hydrocodone abuse increased 68% and 31%, respectively, from 1999 to 2000.36, 39 The sustained-release opioid preparation OxyContin Purdue-Pharma, Stamford, CT ; has also gained notoriety for being abused. OxyContin was developed as a sustained-release opioid for moderate to severe pain that avoided peaks and troughs in analgesic plasma concentrations. OxyContin provides safe and effective pain relief; however, with tampering i.e., crushing and powdering the preparation ; , it may be injected or used intranasally to provide a rapid and powerful opioid effect. Methadone Dolophine [Eli Lilly, Indianapolis, IN] ; is also abused. Oral methadone is not associated with euphoric or pleasurable effects but does provide effective analgesia in the setting of chronic pain and reliable maintenance for recovering addicts. Nevertheless, the oral tablet has high street value because after being crushed, placed into solution, and injected, addicts experience an intense and very prolonged "high."21 Drug addiction refers to a complex phenomenon with behavioral, cognitive, and physiologic components where the use of a particular drug assumes central importance in the user's life, even in the face of obvious physical or psychological harm.20, 21, 37 Essentially, the life of the addicted patient centers on the repeated use of opioid and nonopioid narcotics to experience pleasure or to avoid displeasure i.e., avoiding withdrawal ; . The matter, in actuality, is more complicated than classifying patients as abusers or legitimate users. For example, some patients to whom opioid analgesics are prescribed for chronic pain may actually become addicted to them. For user abusers, pain control is only one of the motivations responsible for drug-seeking behavior and not the central theme, although it may superficially seem so.15, 21, 37 It is difficult to ascertain the prevalence of opioid addiction in chronic pain patients, but a study performed by Fishbain et al.37 found that 319% of chronic pain patients have an addictive disorder, which is comparable to the lifetime prevalence rate of addictive disorders in the general population. Savage15 and others12, 37 have suggested that prevalence of addiction may and prednisone.
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Oxacillin . 12 OXANDRIN . 52 oxaprozin. 47 OXSORALEN ULTRA . 33 oxybutynin. 61 oxycodone . 21 oxycodone acetaminophen . 21 OXYCONTIN . 21 OXYTOCICS. 54 oxytocin . 54 pacerone 200mg tablet . 26 paclitaxel . 17 palcaps. 42 palgic . 59 PALGIC. 59 palgic liquid. 59 PALGIC tablet . 59 palipase, mt . 42 palpeon dr, mt. 42 paltrase . 42 pamidronate. 39 pancrelipase, mst. 42 pancrelipase, mt . 42 pancron . 42 panfil-g. 60 panfil-g syrup . 60 pangestyme ec, cn, mt, ul . 42 PANGLOBULIN NF . 44 panocaps, mt . 42 panokase . 42 PANRETIN . 34 papain urea . 34 papain urea chlorophyllin . 34 papaverine, er . 30 para-time . 30 parcaine . 58 paregoric . 40 PARENTERAL ANTIFUNGALS . 11 paromomycin . 6 paroxetine . 25 PAXIL suspension. 25 PEDIARIX. 44 pedi-dri . 11 PEDVAXHIB . 44 peg electrolytes . 42 PEGANONE. 23 PEGASYS . 45 penicillin g potassium . 12 penicillin g potassium vial. 12 penicillin g procaine. 12 penicillin g sodium . 12 penicillin v potassium . 12 PENICILLINS . 11, 12.
Sentenced him to a total of seven years' imprisonment and also imposed a $100, 000 fine pursuant to section 893.135 1 ; c ; 1 ; Florida Statutes 1997-2001 ; .1 In ground two of his motion, Miller alleged that counsel was ineffective for failing to move to dismiss the charge of possession of clonazepam after Miller informed his trial counsel that he had a prescription for the drug. The facts supporting this claim are contained in the memorandum of law attached to the 3.850 motion. However, the memorandum was not properly sworn to, and the trial court correctly refused to consider it. See Oramas v. State, 615 So. 2d 853 Fla. 2d DCA 1993 ; holding that a rule 3.850 motion is facially insufficient where it is based on facts contained in an unsworn memorandum of law Braun v. State, 789 So. 2d 1250 Fla. 4th DCA 2001 ; holding that an oath in which the defendant swears the statements contained in the rule 3.850 motion are true "to the best of my knowledge and belief" is an inadequate oath for purposes of rule 3.850 ; . Accordingly, we affirm the trial court's dismissal of ground two of Miller's motion without prejudice to any right Miller might have to present his claim in a properly sworn rule 3.850 motion. See Oramas, 615 So. 2d 853. In ground three, Miller alleged that the $100, 000 fine for trafficking in oxycodone was illegally imposed. Miller based his claim on our opinion in Taylor v. State, 818 So. 2d 544 Fla. 2d DCA ; , review dismissed, 821 So. 2d 302 Fla. 2002 ; . In Taylor, this court held that chapter 99-188, Laws of Florida, which provided for the imposition of mandatory minimum sentences for certain drug offenses, is unconstitutional because it violates the single subject rule of the Florida Constitution. In.
Scribers through the VISN formulary committees. Several interactions have been addressed, including 1 ; concomitant use of selective serotonin reuptake inhibitors with codeine, where the former may decrease the metabolism of codeine to morphine by inhibiting cytochrome P-450 2D6, thereby decreasing its therapeutic benefit21-23; 2 ; the potential interactions between protease inhibitors and the hydroxymethylglutaryl coenzyme-A reductase inhibitors statins ; lovastatin and simvastatin, where protease inhibitors may inhibit statin metabolism, leading to higher drug concentrations and, possibly, an increased risk for myopathy and rhabdomyolysis24-31; and 3 ; the combination of statins and fibrates, which has the potential to induce rhabdomyolysis and death.32-37 Next, in monitoring new drugs used increasingly throughout the VA system, the VA PBM conducted an analysis on ziprasidone, an atypical antipsychotic, which can cause potential cardiovascular risks through prolonged QTc intervals, especially in patients who have cardiovascular disease, use concomitant drugs that can prolong QTc, or take drugs that inhibit the metabolism of ziprasidone.38-49 The evaluation tracked patients with a diagnosis of schizophrenia and looked at histories of cardiovascular disease, antipsychotic switching patterns, discontinuation rates of ziprasidone, and concomitant use with contraindicated medications. The VA PBM also initiated a database review of oxycodone, a drug with abuse potential. Results prompted the VA PBM to develop national criteria for use as well as an employee education program, and to institute an automated system to periodically review patients who obtained a prescription for any formulation of oxycodone nationwide. Moreover, the VA PBM conducts drug use evaluations to analyze adverse drug events, assess compliance with predetermined criteria and standards of practice, and estimate related pharmaceutical costs.7 An example of a drug use evaluation completed by the VA PBM evaluated the clinical impact of a systemwide switch from troglitazone to rosiglitazone or pioglitazone with respect to potential exacerbation of congestive heart failure or hepatotoxicity after the market withdrawal of troglitazone.11 This project further evolved into the development and implementation of the nationwide VA Thiazolidinedione Registry, which monitor rates and relative risk of adverse outcomes such as congestive heart failure, hepatotoxicity, hyperlipidemia, and mortality in the VA diabetic patient population. Other registries and safety outcomes projects include the Antipsychotic and Diabetes Outcomes Study, the Fluoroquinolone Glycemia Safety Study, and the Leflunomide Registry. ; The VA PBM performed a drug use evaluation to investigate rabeprazole therapy after a systemwide therapeutic interchange from lansoprazole. The results revealed that many patients switched to rabeprazole discontinued therapy because of symptom recurrence due to inadequate titration of rabeprazole doses, demonstrating the need for provider education. In another national drug use evaluation, the VA PBM assessed the appropriate use of tamsulosin for benign prostatic hypertrophy. Results showed provider noncompliance with national criteria, manifested by unnecessary and increased utilization of this agent, which prompted the VA PBM to implement a formal provider education process.10 and oxycontin.
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17 Sanguinetti, MC, Chen, J, Fernandez, D, Kammiya, K, Mitcheson, J, and SanchezChapulala, JA. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs. Novartis Found Symp. 266: 159-1566; discussion, 2005.
Nephrology, 2Fisiopatologia, 3Laboratorio Clnico, Facultad de Medicina, Hospital de Clinicas, Montevideo, Uruguay Introduction: There is growing evidence that mTOR inhibitors can play a role in the prevention of progression of different nephropathies even in those of non-immunologic origin. Everolimus has intense antinflammatory and antiproliferative effects. Our aim is to evaluate the benefits of using everolimus to attenuate kidney damage in 5 6 nephrectomy model. Methods: Male Wistar rats with a body weigth of 296 27 g. were randomly assigned to different groups. Sham operated N 7 ; , and right nephrectomy plus ligature of 2 3 branches of left renal artery 5 6 NFX ; . Two weeks later they were randomly assigned to control group CG ; N 11 ; and everolimus EG ; 0.3 mg kg d per os N 8 ; daily gavages. After eight weeks of treatment, body weight, systolic blood pressure, arterial bicarbonate, plasma creatinine, BUN, proteinuria, urine creatinine and low weight urine proteins by HPLC were measured. Histologic glomerular and tubulointerstitial damage were measured PAS stain ; , and glomerular and tubulointerstitial proliferating cell nuclear antigen PCNA ; positive cells, CD68 positive cells and alfa smooth muscle actin staining were studied by immunohistochemistry with semiquantitative scores. The groups were compared by one way analysis of variance ANOVA ; test followed by post hoc pair-wise comparisons using Student-Newman-Keuls test. We consider significant a "p" value less than 0.05 Results: When comparing the control group with the everolimus treated group there were no differences in blood pressure, plasma creatinine and creatinine clearance. EG showed significant lower proteinuria and albuminuria measured by HPLC than CG 142, 394, 8 vs 279, 3125, 3 mg d ; and 6, 834, 6 vs 12, 94, 9 mg ml ; respectively p 0.05 ; . The histology comparison between groups showed less glomerular GS ; and tubulointerstitial TIS ; damage in EG vs CG: GS 0, 3 0, 43 1.4 0, 73 ; , p 0.05 ; and TIS 2, 46 1, vs 6, 0.05 ; . EG showed less alfa actin staining, GS 0, 190, 14 vs 0, 860, 71, p 0.05 ; and TIS 1.030, 52 vs 2, 060, 55, p 0.05 ; than CG. There were no differences in PCNA and CD68 between EG and CG. Conclusion: Everolimus decrease proteinuria and albuminuria and showed less damage and fibroblast activation measured by GS and TIS scores, even though the EG remained with high blood pressure. We were not able to demonstrate improvements in renal function measured by creatinine clearance. Taken together these results suggest a beneficial mTOR inhibition effect to prevent progressive renal damage.
| Oxycodone photosOXYCODONE- ASPIRIN PERCODAN ; . Tier 1 OXYCONTIN [OXYCODONE] QL ; Tier 3 PERCOCET.
The Committee has made some changes in the presentation of verdicts to make them more informative and provide some insight into how it reaches its decisions. Instead of using the descriptive terms "appropriate", "restricted use" and "inappropriate" which are sometimes misused ; , the following categories will be used: Category A- suitable for prescribing in primary care, or Category B- suitable for restricted prescribing under defined conditions, or Category C- not suitable for prescribing in primary care The second change is the use of a quadrant grid is to provide more information about what the Committee feels is the strength of the evidence for whether and how well the drug works, and where its place is in therapy in primary care. This will be used for drugs in Category A and B, i.e. those that the Committee feels can be prescribed in primary care. The drug will be given a Q1, Q2, Q3 or Q4 rating reflecting how far along the horizontal axis the strength of the evidence is considered to lie, and whether its place in therapy on the vertical axis ; is considered to be relatively low or high, for instance, oxycodone morphine.
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