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Remember the fuss last year over flu vaccines? "And asthma inhalers? "And the current crisis of herceptin for breast cancer sufferers? "These are just a few examples of where our current approach to the use of pharmaceuticals is failing people. We presently ration the availability of these medicines to people by their price. "PHARMAC, the government's drug buying agency does a good job in making sure we get medicines at the best price, but in the absence of other policies, is increasingly making clinical decisions about he availability of medicines based on cost-efficiency. "In other word, high cost medicines for small groups of patients are often not subsidised which means they are usually out of people's reach ; because they are not deemed to be sufficiently cost efficient.
Because of such limitations, there is a risk that material misstatements may not be prevented or detected on a timely basis by internal control over financial reporting. However, these inherent limitations are known features of the financial reporting process. Therefore, it is possible to design into the process safeguards to reduce, though not eliminate, this risk. Management is responsible for establishing and maintaining adequate internal control over financial reporting for the company. Management has used the framework set forth in the report entitled Internal Control-Integrated Framework published by the Committee of Sponsoring Organizations of the Treadway Commission, known as COSO, to evaluate the effectiveness of the Company's internal control over financial reporting. Based on this assessment, management has concluded that our internal control over financial reporting was effective as of December 31, 2005. Ernst & Young LLP, the independent registered public accounting firm that audited the consolidated financial statements included in the Annual Report on Form 10-K, has issued an attestation report on management's assessment of the effectiveness of our internal control over financial reporting as of December 31, 2005. This report which expresses an unqualified opinion on management's assessment of and the effectiveness of our internal controls over financial reporting as of December 31, 2005 is included herein. There has been no change in our internal controls over financial reporting during our most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, our internal controls over financial reporting, for example, medications. If manual is difficult organs at providers should phenoxybenzamine marry.
Derived growth factor-stimulated mitogen-activated protein kinase cascade. Hypertension 31: 665-671, 1998. ; Hougaku H, Matsumoto M, Hata R, Handa N, Imaizumi M, Sugitani Y, Yoneda S, Etani H, Sueyoshi K, Kusunoki M: Therapeutic effect of lisuride maleate on post-stroke depression. Nippon Ronen Igakkai Zasshi 31: 52-59, 1994, in Japanese. 6 ; Isozumi K, Izumi Y: Experimental models and treatment trials for cerebral infarction. Tokai J Exp Clin Med, in press. 7 ; Isozumi K, Izumi Y, Fukuuchi Y, Gotoh F: Effects of nilvadipine on cerebral circulation and metabolism in cats. Arzneimittelforschung 40: 421-424, 1990. ; Isozumi K, Izumi Y, Fukuuchi Y, Gotoh F: Effects of mergocriptine on cerebral circulation and metabolism in cats. Arzneimittelforschung 42: 901-903, 1992. ; Izumi Y: Antiplatelet therapy for TIA and cerebral infarction. Gendai Iryo 25: 3773-3778, 1993, in Japanese. 10 ; Izumi Y, Shinohara Y: Effective usage of cerebral vasodilators and metabolic activators. Clinic Magazine 6: 56-61, 1995, in Japanese. 11 ; Izumi Y, Fukuuchi Y, Imai A, Isozumi K: Alphaadrenergic blockade with phenoxybenzamine enhances cerebrovascular CO2 reactivity. Keio J Med 42: 60-63, 1993. ; Izumi Y, Fukuuchi Y, Imai A, Isozumi K: Effect of clonidine on the cerebrovascular system in cats. Keio J Med 42: 64-69, 1993. ; Izumi Y, Shinohara Y: Stroke recurrence and hypotensive therapy. Cardiac Practice 5: 169-174, 1994, in Japanese. 14 ; Izumi Y, Gotoh F, Fukuuchi Y, Hata T, Imai A, Isozumi K: Role of the sympathetic system in impairment of the cerebrovascular CO2 responsiveness during moderate hypoglycemia. Keio J Med 41: 134-140, 1992. ; Izumi Y, Gotoh F, Fukuuchi Y, Isozumi K: Role of cyclooxygenase system in cerebrovascular responsiveness: different effects of indomethacin on CO 2 responsiveness and dilatation by Ca2 + -channel blocker. Keio J Med 41: 205-211, 1992. ; Izumi Y, Isozumi K, Fukuuchi Y: Effect of sympathetic nervous system stimulation on cerebrovascular CO2 responsiveness. Tokai J Exp Clin Med 18: 117122, 1993. ; Izumi Y, Isozumi K, Fukuuchi Y: Effect of sympathetic stimulation on cerebral circulation. Tokai J Exp Clin Med 19: 13-17, 1994. ; Izumi Y, Isozumi K, Fukuuchi Y, Gotoh F: Effects of 2-nitratopropyl 3-nitratopropyl 2, ; -1, 4-dihydropyridine-3, 5-dicarboxylate on cerebral circulation and metabolism in cats. Arzneimittelforschung 39: 438-440, 1989. ; Kabasawa H, Matsubara M, Kamimoto K, Hibino H, Banno T, Nagai H: Effects of bifemelane hydrochloride on cerebral circulation and metabolism in patients with aphasia. Clin Ther 16: 471-482, 1994. ; Kawagoe J, Abe K, Ikuta J, Igarashi N, Shimizu S, Yamauchi Y, Kogure K: Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantita. A b c choose phenoxybenzamine strength quantity and click buy-button.

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