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Figure 1. Increased therapeutic competition. Inderal 1968 Tagsmet 1977 Capoten 1980 Seldane 1985 AZT 1987 Mevacor 1987 Prozac 1988 Diflucan 1990 Recombinate 1992 Invirase 1995 Celebrex 1998 Relenza 1999 0 1 2 Years of exclusivity 8 9 10.
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This guideline addresses the assessment, diagnosis and management of asthma in children and young people aged 1-15 years inclusive. The guideline summarises the latest international literature and combines this with New Zealand expertise. The purpose is to assist informed decision making by parents caregivers and their health care providers in order to improve the health outcomes for children and young people with asthma. This guideline does not address young people 16 years and over and adults refer to the Diagnosis and Treatment of Adult Asthma NZ Guidelines Group 2002 ; ISBN: 0473-08827-4. This guideline complements the Paediatric Society of New Zealand Guideline for the Diagnosis and Management of Wheeze and Chest Infection in children under 1 year 2004 and terbinafine, for example, tagamet dosage.
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Conclusion cond: presence of contaminants on processed ophthalmic instruments. TRAUMA 6. Post-traumatic visual outcome assessment by the Ocular Trauma Classification System OTCS ; H K Rai, S Ghose, M Chandra, S M Betharia, V B Wagh Dr RPC for Ophthalmic Sciences, AIIMS, New Delhi, India Purpose: To comprehensively analyze the prognostic factors responsible for visual outcome in ocular trauma and to test the prognostic significance of the Ocular Trauma Classification Group's Classification. Method: 305 consecutive patients of ocular trauma getting admitted through our casualty services were included in this study. All factors that could affect final visual outcome were recorded. 240 patients could be followed for at least 6 months and were statistically analyzed. Results: Final BCVA correlated significantly well with initial vision; the zone, grade, size and type of injury, & pupillary reactions; as well as with non-OTCS criteria ; IOP, endophthalmitis, lens and posterior segment status. Conclusion: Our study has shown that visual acuity at presentation, zone of injury, grade of injury, pupillary reactions, type of injury, size of injury, endophthalmitis, IOP, lens status and posterior segment findings are of great significance in predicting final visual outcome.The evaluation of the eyes with trauma according to the Ocular Trauma Classification System seems logical, practical and effective.This system's uniform parameters and nomenclature could afford more accurate clinical and research comparisons, irrespective of geographical origin. 7. Factors influencing the visual outcome of posterior segment retained intraocular foreign bodies RIOFB ; : a prospective study. K C Madhusudhana, Rajpal, Y R Sharma, D Talwar Dr R P Centre for Ophthalmic Sciences, New Delhi, India Purpose: To study the factors influencing the final visual outcome in posterior segment RIOFB and to study the surgical outcome in a tertiary referral centre in India. Method: This prospective study was conducted in Dr.Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India. 50 consecutive cases of self-sealed repaired corneal or scleral penetrating injury with posterior segment RIOFB were enrolled in the study.They underwent thorough ophthalmic examination and investigations such as X-ray CT scan of orbits, flash Electroretinogram ERG ; and flash Visual evoked response VER ; wherever possible. All patients underwent standard pars plana vitrectomy and foreign body removal. Results: 58% of patients were in the age group 20-30 years, with right eye being affected in 56% of cases. Hammering metal with metal was the commonest mode of injury 78% ; . Cornea was the site of entry in 68% of cases. 80% had an injury 5 mm. Lens was cataractous in 74% cases, subluxed in 2 cases bomb blast ; . 38% had vitreous haemorrhage. In 89% of cases, foreign body was located in front of or on the retina. Foreign bodies were metallic in 93% of cases, 66% measuring less than 3 mm. Final visual acuity VA ; of 6 was achieved in 44% of cases. 6 patients had a final VA of 6 12. Conclusion: The predictors of good visual outcome were good initial VA, corneal injury, injury 5mm, ERG amplitude of 50%, normal VER latency and surgery during the interval of 7-14 days after injury. Final VA was not related to age and fundal visibility. 8. Prognostic factors in open globe injuries. M C Corbett, D J De Silva Western Eye Hospital, London Purpose: Our aim was to evaluate factors associated with poor visual outcome following the surgical management of open-globe injuries. Method: A retrospective observational study of patients who underwent surgical management of open globe injuries following ocular trauma in West London over a 6-year period from December 1998 to October 2004. Of the 74 cases, 58 78% ; were statistically analyzed, and all patients with less than 6 months follow-up excluded. Results: Fifty-eight cases of open globe injuries 37 [64%] men, 21 [36%] women ; were identified and the mean age at admission was 39.4 years. Presenting VA was CF or less in 82%, however in the 8% with VA better than 6 12, all maintained their VA postoperatively. Statistical analysis 2 anal ysis ; showed that the most important factors related to a poor postoperative VA CF ; were: Globe injury secondary to rupture, central or paracentral corneal injury and the presence of vitreous loss, hyphaema or retinal detachment.The excision of prolapsed iris was associated with monocular diplopia or glare in 2 of cases, and required the insertion of a prosthetic iris. Orbital or adnexal injuries were present in 24% 14 ; of patients with open globe injuries, and were associated with a poorer visual acuity at presentation that improved post surgery. Conclusion: Ocular trauma is an important cause of visual reduction. Concurrent adnexal or facial injury is associated with a poor VA at presentation, and surgical excision of prolapsed iris associated with an increased risk of refractive symptoms requiring surgical correction.
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DKK 62, 712 from Novo Nordisk A S - a one-year Novo Nordisk Scholarship. Ingrid Kjller Larsen DKK 70, 000 from DANSYNC, Danish Centre for Synchrotron Based Research. DKK 250, 000 from the Danish Medical Research Council for the project "Protein crystallography in drug research. Structure determination of biomacromolecules and their complexes with ligands drugs 2001-2003 ; ". DKK 80, 000 from the Novo Nordisk Foundation for the project "Protein crystallography in drug research. Characterization of biomacromolecules by dynamic light scattering". For additional research centre grants see "Research Centres Grants, for example, tabamet 400.
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Iannuzzi et al. examined 307 healthy middle-aged women participants in a population-based study on the etiology of CVD and cancer ; by ultrasound to detect early signs of carotid atherosclerosis. They also measured plasma concentrations of vitamin A, vitamin E and carotenoids, and evaluated dietary intakes with a foodfrequency questionnaire. The presence of atherosclerotic plaques at the carotid bifurcation where atherosclerosis usually begins ; was inversely related to vitamin E intake, as well as to the ratio of plasma vitamin E to plasma cholesterol. Only women in the highest tertile of vitamin E intake consumed more than 8 mg daily current recommendations for women are between 12 and 15 mg ; . There was no association between the presence of carotid plaques and the other antioxidant nutrients measured.
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