Lasch, Christopher, The Minimal Self: Psychic Survival in Troubled Times. Norton, New York: 1984. Lawler, Peter Augustine, Aliens in America: The Strange Truth About Our Souls. ISI, Wilmington, Delaware: 2002. Lawler, Peter Augustine, Postmodernism Rightly Understood: The Return to Realism in American Thought. Rowman & Littlefield, Lanham: 1999. Lawson, Lewis, Following Percy: Essays on Walker Percy's Work. Whiston, New York: 1988. MacIntyre, Alasdair, After Virtue. UND Press, Notre Dame, IN: 1981. MacIntyre, Alasdair, "How Can We Learn From What `Veritatis Splendor' Has to Teach?, " The Thomist 58 April, 1994 ; . Maritain, Jacques, The Dream of Descartes: Together With Some Other Essays. Philosophical Library, New York: 1994. Maritain, Jacques, The Degrees of Knowledge, translated from the 4th edition by Gerald Phelan. UND Press, Notre Dame, IN: 1995. Martini, Carlo Maria, On the Body: A Contemporary Theology of the Human Person, translated by Rosanna Giammanco Frongia. Crossroad, New York: 2000. McHugh, Paul & Slavney, Phillip, The Perspectives of Psychiatry, 2nd edition. Johns Hopkins, Baltimore, MD: 1988. Pellegrino, Edmund, Physician and Philosopher: The Philosophical Foundation of Medicine. Carden Jenninigs, Charlottsville, VA: 2001. Percy, Walker, Lost in the Cosmos: The Last Self-Help Book. Farrar, Strauss & Giroux, New York: 1983. Percy, Walker, Love in the Ruins: The Adventures of a Bad Catholic at Some Time Near the End of the World. Farrar, Strauss & Giroux, New York: 1971. Percy, Walker, Message in a Bottle. Farrar, Strauss & Giroux, New York: 1975. Percy, Walker, Signposts in a Strange Land. Farrar, Strauss & Giroux, New York: 1991. Percy, Walker, The Thanatos Syndrome. Farrar, Strauss & Giroux, New York: 1987. Pinckaers, Servais, O.P. The Sources of Christian Ethics, translated from the 3rd edition by Sr. Mary Thomas Noble, O.P. CUA Press, Washington, DC: 1995.
Less that 3% of the hospital patient population is eligible to donate solid organs. Most healthcare professionals lack the specialized training needed to help families through the multidimensional aspects of the declaration of brain death. Attitudes of healthcare professionals strongly influence and may complicate decision-making regarding brain death and end of life. Variations among hospitals in brain-death criteria and methods of death sometimes cause further confusion, for example, ticlopidine mechanism.
5.1 LIFE-STYLE INTERVENTION AS A PREVENTIVE MEASURE The studies previously presented on life-style intervention of cardiovascular disease can be divided into those where the clinical effects are based on hypothetical interventions and those where it is based on clinical trial data or a meta-analysis of such data. The former are interesting to generate hypotheses, but to get reliable results it is important to have good underlying clinical data. This is important, as the cost-effectiveness of lifestyle interventions is determined not only by the cost of the intervention, but also by the demonstrated health effects of this program. This explains the different finding in our study compared to those of Salkeld and Johannesson. [32, 33] A program with no measurable health benefits compared to standard treatment can only be considered if it is associated with lower costs. The lesson from this is that the first and most important step is to establish that an intervention program works and has a clinical effect. Once this is established, it is time to assess whether or not it is economically justifiable. The only previously published study based on significant effects based on a meta analysis ; indicated that exercise is cost-effective. [35] Our finding confirms this, but also indicates that dietary advice is cheaper and based on our clinical results, more effective. In the absence of dietary advice as a comparator, the cost-effectiveness ratios for exercise are favorable. Palmer and colleagues found that intensive lifestyle intervention was cost-saving when using a simple Markov model based on data from the DPP. [82] Using a more detailed model, populated by completely different data chiefly DPS and UKPDS ; and a different set of costs we find the same thing in Sweden. Including all costs, i.e. also costs due to increased survival, our model predicts a very favorable cost-effectiveness ratio. This gives a very strong argument for implementing this type of program, particularly for the Swedish county councils who are the parties that will reap the benefits of the cost-savings. A drawback of many studies on lifestyle intervention is their limited follow-up time. This is of course a question about quite different economics: research funding. This leads to two problems for economic evaluations. The first is the fact that the endpoints included in the studies are limited to surrogate endpoints as reduction in risk factor levels. This is generally considered to have slightly less value as evidence than trials with reduction in `hard' endpoints such as mortality or reduction of cardiovascular events as outcome measures. It also forces us to model the effect from the intervention through the use of risk-equations instead of as a reduction in absolute risk. This adds uncertainty as there is uncertainty included when estimating the risk equation in the first place and the appropriate risk function needs to be used for the studied population. The second issue with short duration of follow-up is that the maintenance of either the effect of the intervention or the persistence with which the intervention is this is assumed to be continued is unknown. In both our studies, we assumed that intervention would be discontinued and that there would be no remaining effects or a rapid progression back to the baseline levels for the risk factors. This is the most conservative 29.
Accessed may 20, 200 hass wk, easton jd, adams hp jr, et al, a randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients, n engl j med , 1989, 321 8 ; : 501- kastrati a, schuhlen h, hausleiter j, et al, restenosis after coronary stent placement and randomization to a 4-week combined antiplatelet or anticoagulant therapy: six-month angiographic follow-up of the intracoronary stenting and antithrombotic regimen isar ; trial, circulation , 1997, 96 2 ; : 462- leon mb, baim ds, popma jj, et al, a clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting.
Because the kinds of treatments that the complementary and alternative doctors use are not economically driven by the pharmaceutical industry, there isn't the motivation to produce costly studies to get approval.
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LACKS ARE DISPROPORTION ately affected by stroke, yet they have been underrepresented in clinical trials.1-8 Recommendations for stroke prevention in this population have been based largely on trials that have included few black participants. This may not be an optimal practice because blacks are among those with a higher prevalence of major cardiovascular risk factors, a different distribution of atherosclerotic occlusive cerebral vascular lesions, vascular biological differences such as low renin hypertension, and a different pattern of use of medical procedures and access to care8-13 that could influence outcome. A subgroup analysis of the Ticlopidjne Aspirin Stroke Study TASS ; 14, 15 suggested a more favorable riskbenefit profile for nonwhites than whites. Specifically, among the 495 black and 108 nonwhite and non.
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Ticlopidine is associated with neutropenia in 5% of patients and life-threatening thrombotic thrombocytopenia purpura in a small number of patients consequently, most interventionalists have replaced ticlopidine with clopidogrel, which appears to offer similar efficacy but significantly less side effects still, the addition of a second antiplatelet agent to aspirin comes at a price.
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Routine clinical and laboratory evaluation of the patient, or failure to achieve blood pressure control. In addition to primary and secondary hypertension, the clinician may encounter what is referred to as resistant hypertension. Patients failing to achieve goal blood pressure despite maximum doses of three antihypertensives including a diuretic should be carefully screened for resistant hypertension. Several causes of resistant hypertension are listed in Table 22 and should be carefully considered in such patients and
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Carl G H Dahlf, MD, PhD, is the Medical Director and Medical Superintendent of Gothenburg Migraine Clinic, which he founded in 1991. Since April 2002, he has been Professor of Neurology at the Institute of Clinical Neuroscience at Sahlgrenska University Hospital and is responsible for medical training in headache diagnosis and management. Professor Dahlf is recognised as a world expert in migraine diagnosis and treatment and serves as an international consultant on several advisory boards. He has authored about 250 publications, including original articles, books, chapters and reviews, and is an active member of numerous professional associations in his native Sweden and internationally. He is Vice Chairman of the Swedish Society of Migraine and a member of the American Association for the Study of Headache, the European Headache Federation, the International Headache Society and several other organisations. He serves on the editorial board of Headache Care and Headache Currents. Professor Dahlf received his medical training at the Faculty of Medicine at the University of Gothenburg. He will be president of the 13th Congress of the International Headache Society IHC ; , which will be held in Stockholm in 2007.
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Patients at 6 months, 8 patients at 12 months, and 9 patients at 24 months ; were not included in the study and analyzed separately. Eighty out-patients matched for gender, age, and risk factors for atherosclerosis and treated with ticlopidine 250 mg day ; instead of aspirin were enrolled with the same inclusion criteria and used as the control group. Patients were considered hypertensive if blood pressure was 140 90 mm Hg least three different measurements when patients were in a supine position for at least 10 min or if they were treated with antihypertensive drugs. Patients were considered hypercholesterolemic if serum cholesterol was 240 mg dl or if they were treated with lipid-lowering agents, and diabetic if they received treatment with oral antidiabetics or insulin. No difference in the prevalence of hypertension 45% vs. 41% ; , hypercholesterolemia 31% vs. 34% ; , diabetes 7.2% vs. 8.5% ; , and smoking 15.3% vs. 16.4% ; was observed between ticlopidine and aspirin-treated patients, respectively. Blood samples anticoagulated with sodium citrate ratio 9: 1 ; were taken from each patient after at least 12 h of fasting. As previously described 6 ; , platelet aggregation according to Born's method ; was evaluated considering the maximal percentage Mx% ; of platelet aggregation in response to 2 mol l adenosine diphosphate ADP ; and 1 mmol l arachidonic acid, and Mx% as well as the lag phase in response to 2 g collagen. The lag phase was defined as the delay time occurring between the addition of collagen and the beginning of the aggregation curve; the Mx% was calculated as the light transmission difference between platelet-rich plasma and platelet-poor plasma 100% ; . All of the platelet agonists used and the aggregometer were from Helena BioSciences Sunderland, United Kingdom concurrent control studies were performed to ensure that all agonists retained the same level of activity during the whole study. Statistical analysis. All data are reported as the mean value SD and, where appropriate, as median values and ranges. To compare the groups, analysis of variance was performed for data normally distributed lag phase ; , and post hoc analysis Dunnett's test ; was used to test for changes from baseline to post-treatment times. The Kruskal-Wallis test was performed for skewed data Mx% of platelet aggregation ; to compare the different responses obtained before and after 2, 6, 12, or 24 months treatment. The Wilcoxon test was performed to further confirm the significant differences observed between the two groups. Significance was accepted and tiotropium.
2 rupprecht hj, et al : comparison of antiplatelet effects of aspirin, ticlopidine, or their combination after stent implantation.
1. Sandercock P, Warlow C, Bamford J, Peto R, Starkey I. Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile? Lancet 1986; 1: 788-92. A double-blind trial to assess long-term oral anticoagulant therapy in elderly patients after myocardial infarction: report of the Sixty Plus Reinfarction Study Research Group. Lancet 1980; 2: 989-94. The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N Engl J Med 1990; 323: 1505-11. Ezekowitz MD, Bridgers SL, James KE, et al. Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. N Engl J Med 1992; 327: 1406-12. [Erratum, N Engl J Med 1993; 328: 148.] Stroke Prevention in Atrial Fibrillation Investigators. Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study. Lancet 1994; 343: 687-91. Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation: the Copenhagen AFASAK study. Lancet 1989; 1: 175-9. Goldstein LB, Adams R, Becker K, et al. Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 2001; 32: 280-99. Bousser MG, Eschwege E, Hageunau M, et al. "AICLA" controlled trial of aspirin and dipyridamole in the secondary prevention of atherothrombotic cerebral ischemia. Stroke 1983; 14: 5-14. Hass WK, Easton JD, Adams HP Jr, et al. A randomized trial comparing ticlopirine hydrochloride with aspirin for the prevention of stroke in high-risk patients. N Engl J Med 1989; 321: 501-7. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events CAPRIE ; . Lancet 1996; 348: 1329-39. European Stroke Prevention Study 2: efficacy and safety data. J Neurol Sci 1997; 151: Suppl: S1-S77. 12. Mohr JP. Cryptogenic stroke. N Engl J Med 1988; 318: 1197-8. The WARSS, APASS, PICSS, HAS, and GENESIS Study Groups. The and tizanidine.
| Ticlopidine adverse effectExpenditure on medicinal drugs 2005 ; : 2.473 Mio, for example, stroke.
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Ticlopidine was found to be modestly but significantly more effective than aspirin in preventing serious vascular events in patients at high risk, but there is uncertainty about the size of the additional benefit and urso.
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And 100 and 25 ng mL urine for irinotecan and SN-38, respectively, using 50 AL aliquots. Pharmacokinetic parameters were calculated by standard noncompartmental methods using WinNonlin software version 3.3 Pharsight, Mountain View, CA ; , using standard equations. Nonpredicted accumulation was calculated as the ratio of area under the plasma concentration-time curve AUC ; -over-onedosing-interval 24 hours ; on day 5 over AUC-extrapolated-toinfinity on day 1. Pharmacogenetic Data Analysis. Genomic DNA was extracted from 200 AL plasma using a total nucleic acid extraction kit on a MagnaPure LC Roche, Mannheim, Germany ; . Variations in the ABCB1 nucleotide 3435 C T; ref. 25 ; , CYP3A4 CYP3A4 * 3, CYP3A4 * 17, and CYP3A4 * 18 ; , CYP3A5 CYP3A5 * 3 ; genes were analyzed by PCR-RFLP as previously reported 26, 27 ; . For UGT1A1 * 28, a 35-cycle PCR 1 minute at 94jC, 1 minute at 60jC, and 1 minute at 72jC ; was done using primers 5V -FAM-AAG TGA ACT CCC TGC TAC CT-3V and 5V -AAA GTG AAC TCC CTG CTA CC-3V The . number of TA repeats in the 253-bp PCR product was determined using capillary electrophoresis on an ABI 310 Applied Biosystems, Foster City; ref. 14, 15 ; . Genetic polymorphisms were correlated with pharmacokinetic parameters obtained in fasted condition cycles in 23 patients. Statistical Analysis. Pharmacokinetic parameters from the various treatment groups were compared statistically using SAS version 8.2 SAS Institute, Inc., Cary, NC ; . To compare the pharmacokinetic parameters with the genetic polymorphisms a Kruskal-Wallis test SPSS version 10.1, Paris, France ; was used or a nonparametrical trend analysis Stata version 7.0, Stata Corp., College Station, TX; ref. 15 ; . All test results with a P 0.05 were regarded as statistically significant.
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With a 50h discount rate, the lifetime costs of clopidogrel and generic ticlopidinf therapy both decrease to $70, 193 and $66, 948 respectively. The incremental difference in lifetime cost of clopidogrel versus generic tclopidine therapy is $3, 245 versus $3, 719 in the baseline analysis. The incremental difference in the number of LYSgained is 0.09 LYSversus 0.1 LYS gained in the baseline analysis. The incremental cost LY is higher, at $36, 084 tY1in comparison to the baseline result.
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Published: 5 april 2001 bmc pharmacology 2001, 1: this article is available from: : biomedcentral 1471-2210 1 c ; 2001 kamau et al, licensee biomed central ltd.
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H. Bokil, M. Laaris, K. Blinder, M. Ennis and A. Keller Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
The Internet Journal of Family PracticeTM ISSN: 1528-8358 Daily Application Of The Homeopathic Remedy Zicam Allergy Relief Significantly Improves The Quality Of Life And Impairment In Patients With Seasonal Allergic Rhinitis Sion Nobel, MD Mission Hills Medical Center Citation: Sion Nobel: Daily Application Of The Homeopathic Remedy Zicam Allergy Relief Significantly Improves The Quality Of Life And Impairment In Patients With Seasonal Allergic Rhinitis. The Internet Journal of Family Practice. 2000. Volume 1 Number 1. Table of Contents Abstract INTRODUCTION Methods Results Discussion Disclosure Statement References.
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Two hundred thirty-three pediatricians replied to the survey, representing a response rate of 24.4%, similar to the response rate on a previous survey of this group of pediatricians.11 The characteristics of the respondents are shown in Table 2. Mean age was 47.1 9.7 years and slightly over half were female. The majority 63% ; were in solo or group private practice. Twenty-six percent worked in an academic practice or hospital-based clinic. Seventy-six percent of respondents spent 50% of their time practicing general pediatrics, with only 16.7% spending 50% of their time in subspecialty pediatrics. Respondents did not differ from nonrespondents with respect to age, gender, or nature of practice as determined from the previous survey.11 Twenty-four percent of respondents had been confronted with the decision to prescribe EC, usually for unprotected intercourse 36 of 55 65.5% of those who replied in the affirmative ; . Twenty-seven of the 55 pediatricians who had been asked to prescribe EC 49.1% ; had been asked to do so for a patient who was the victim of rape Table 3 ; . When asked how frequently they had been asked to prescribe EC, 174 of 226 respondents 77.0% ; had not been confronted with that situation within the past 12 months. Fifty-one pediatricians 22.6% ; had been asked to prescribe EC in the previous year, but infrequently 26 were asked once and 25 were asked "a few times, " but less frequently than once per month ; . There were no significant differences in requests for EC or in prescribing patterns by gender or practice type. Compared with older physicians, physicians under 40 years of age were more likely to have been confronted with the decision to prescribe EC P .01 ; . Although 79% of pediatricians counseled adolescents about methods of contraception.
Ticlid ticlopidine hydrochloride ; : inhibitor of platelet function [product monograph]. Mississauga ON ; : Hoffmann-La Roche; 1998. 2. Steinhubl SR, Tan WA, Foody JM, Topol EJ. Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. JAMA 1999; 281 9 ; : 806-10. 3. Balsano F, Rizzon P, Violi F, Scrutinio D, Cimminiello C, Aguglia F, et al. Antiplatelet treatment with ticlopidine in unstable angina. Circulation 1990; 82: 17-26. Becquernin JP. Effect of ticlopidine on the long-term patency of saphenous vein bypass grafts in the legs. N Engl J Med 1997; 337: 1726-31. Bennett CL, Weinberg BS, Rozenberg-Gen-Dror K, Yarnold PR, Kwaan HC, Green D. Thrombotic thrombocytopenic purpura associated with ticlopidine. Ann Intern Med 1998; 128: 541-4. Chen DK, Kim JS, Sutton DMC. Thrombotic thrombocytopenic purpura associated with ticlopidine use: a report of 3 cases and review of the literature. Arch Intern Med 1999; 150: 311-4. Szto GY, Linnemeier TJ, Ball MW. Fatal neutropenia and thrombocytopenia associated with ticlopidine after stenting. J Cardiol 1999; 83 1 ; : 138-9. 8. Love BB, Biller J, Gent M. Adverse hematological effects of ticlopidine: prevention, recognition and management. Drug Safety 1998; 19 2 ; : 89-98. 9. Barnett HJM, Eliasziw M, Meldrum HE. Prevention of ischemic stroke [letter]. N Engl J Med 1995; 333: 460. Gill S, Majumdar S, Brown NE, Armstrong PW. Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative. Can J Cardiol 1997; 13 10 ; : 909-13. 1.
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REFERENCES 1. Keljo DJ, Squires RH Jr. Anatomy and anomalies of the small and large intestine. In: Feldman M, Scharschmidt BF, Sleisenger MH, eds. Sleisenger & Fordtran's Gastrointestinal and Liver disease: Pathophysiology diagnosis management, 6th ed. Philadelphia PA WB Saunders Company, 1998: 1419-1436. 2. Meunier P. Mollard P, Marchal J-M. Physiopathology of megarectum: The association of megarectum with encopresis. Gut 1976; 17: 224-227. De Medici A, Badiali D, Corazziari E, Bausano G, Anzini F. Rectal sensitivity in chronic constipation. Dig Dis Sci 1989; 5: 747-753. Whitehead WE, Wald A, Diamant NE, Enck P, Pemberton, JH, Rao SSC. Functional disorders of the anus and the rectum. In: Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead WE editors. Rome II: the functional gastrointestinal disorders. McLean, VA.
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Initiate coverage with Buy and a six month price target of W44, 000 We initiate coverage with a six month price target of W44, 000, derived by applying a 20% discount to the target P E multiple of 14.5x Korea Investment & Securities' Pharmaceutical Universe ; based on 2006 EPS. We applied a 20% discount to the target P E factoring in weak R&D capacity W2bn, only 3.5% to sales ; and low daily trading volumes less than 10, 000 shares ; . However, the company recorded an operating margin of 33.6% over the past three years, significantly stronger than the sector average of 13.8%, and it should rise to 38.1% over the next three years backed by modest sales of high-margin drugs with strength in synthetic technology. Thus, we believe our price target is relatively conservative, for example, hypertension.
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The term "standard of care" is used in an ordinary non-legal context to refer generally to the level or quality of care, as opposed to its legal meaning in the context of medical malpractice and institutional liability. For example, Canada ranks among the lowest of OECD countries for access to medical technology including MRI, CT scanner, and lithotripter equipment OECD 2001; 2002 ; . Rx&D Notice of Compliance Survey 2001 ; - compiled by KPMG; IMS Health, Canada, Provincial Reimbursement Advisor, May 2003. IMS Health, Canada, Provincial Reimbursement Advisor, May 2003. Health Canada: Canada Health Act, ch. C-6 sec. 3 1984 ; Respiratory Disease in Canada, Health Canada, September 2001 Based on data from Canadian Institute for Health Information, Hospital Morbidity Database 1994 95 and 2000 01. CIHI Release: "Asthma Hospitalizations Declining, Still Number One Cause of Hospitalizations for Children, Reports CIHI", Sept, 26, 2001. Canadian Diabetes Association: "Diabetes Facts, " World Wide Web: : diabetes Section About thefacts See canceradvocacycoaltion ibid. ibid. Health Canada: "Policy Statement from the Drugs Directorate: Priority Review of Drug Submissions" Ottawa ; , December 1997 at 2, as cited in K. Osborne, "Regulation of Pharmaceuticals", in M. Dykeman, ed., Canadian Health Law Practice Manual, Butterworths, 2000 at 10.18. These examples are taken from page 10 of the submission prepared by the Cancer Advocacy Coalition of Canada to the Commission on the Future of Health Care in response to its Discussion Paper, "Pharmacare in Canada May 2002 ; . The paper is available on the Coalition's website canceradvocacycoalition ; . Environics Research Group, National Pulse on Health Survey, Environics Research Group, 2002. ibid. Examples as of June 2003 include the Government of Ontario's record on listing new medicines; the Government of British Columbia's Reference Pricing Policy; and the Government of Nova Scotia's Maximum Allowable Cost policy. Demonstrated by findings of the "National Pulse on Health", Environics Research Group, 2002. Frank Lichtenberg: "Are The Benefits Of Newer Drugs Worth Their Cost? Evidence From The 1996 MEPS The newer the drug in use, the less spending on non drug items ; , " Health Affairs Sept Oct 2001 ; . Frank Lichtenberg, "Benefits and Costs of Newer Drugs: an Update, " Working Paper 8996, National Bureau of Economic Research June 2002 ; . As demonstrated by the "Health Multiplier" paradigm developed by Applied Management Consultants, Jan. 2003. Additional examples include the Ontario BioCouncil Report, Quebec's BAP 15 policy, and numerous studies including Meyer J.A., February 2002; D. Nash et al., 2001; Wertheimer et al, 2001.
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Subacute and acute arterial thrombosis are main concerns, which have promoted a search for new antithrombotic regimens. The combination of aspirin and ticlopidine has been tested in several trials, notably after coronary artery stent placement.3, 18-22 Most of the studies indicate a better efficacy3, 20-22 of the antiplatelet drug combination on bleeding complications, hospital stay duration, and stent thrombotic closure rates. Nevertheless, the most recent study has suggested that stent thrombosis may be equally prevented by aspirin or aspirin ticlopidine.19 Thus, the exact respective pharmacologic value of aspirin, ticlopidine, and the combined therapy remains unknown.
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Coronary artery stenting: the recommended dose of ticlopidine hydrochloride is 250 mg bid taken with food together with antiplatelet doses of aspirin for up to 30 days of therapy following successful stent implantation.
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