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Compounds in Development The following table describes some of our compounds and new indications for our existing products presently under development. ``Submission'' means that product registration documents have been submitted to the FDA, to regulatory authorities in the EU by either the centralized or mutual recognition procedure ; and or to national health authorities in Europe, but not necessarily in all jurisdictions, for example, etoposide vepesid.
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It is very important that behavioral health providers who have not yet registered for M-CARE Connect do so as soon as possible. Registering for M-CARE Connect now will make it possible to view authorizations on this new system when the faxed reports are no longer available. To register for M-CARE Connect, behavioral health providers can use the forms that were attached to the M-CARE Provider Relations email distributed on May 31, 2006. The forms must be completed and faxed together to M-CARE at 734 ; 332-2336. The forms that were distributed are: M-CARE Connect Provider Portal Access Registration Form M-CARE Connect and EDI Electronic Access Agreement These forms are also now available at mcare Providers M-CARE Connect M-CARE Connect Registration Form and Agreement. Providers who have already registered for M-CARE Connect do not need to complete the forms again. Click on : mcare media pdf autogen mcc provider reg agreement for M-CARE Connect registration materials.
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EDUCATION M.D., Indiana University School of Medicine Indianapolis, Indiana May 1992 B.S., Indiana University Bloomington, Indiana Major: Biology Minors: Computer Science, Mathematics May 1987 TRAINING Resident, Preliminary Medicine Methodist Hospital of Indiana Indianapolis, Indiana June 1992 - May 1993 Resident, Neurology Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire July 1993 - June 1996 Chief Resident, Neurology Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire June 1995 - July 1996 Fellow, Behavioral Neurology University of Florida College of Medicine Department of Neurology Gainesville, Florida July 1996 - June 1998 HONORS AWARDS FACULTY - Ohio State University Research Foundation Seed Grant $10, 000 ; - Davis Scholarship $10, 000 ; - Unrestricted Educational Grants Pfizer Eisai $47, 547, $15, 000, $12, 000, $10, 000 ; - NIDA R21 $295, 000 ; - NINDS K23 $844, 715 ; - Ingram-White Castle Foundation $30, 000 ; - Henry E. Coyle Fund of the Columbus Foundations $31, 000 ; - Davis Scolarship $25, 000 ; - Teacher of the Year award from Neurology residents 2001 - Teacher of the Year award from Neurology residents 2002 - 2003 Teacher Recognition Award - American Academy of Neurology - 2004 OSU Excellence in Teaching Award Who's Who in Science and Engineering Who's Who in America and fludrocortisone!
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| Vepesid capsuleUniversity of Maryland, in commentary during question and answer period of the Symposium, Obesity and Mortality: Controversy, Research, and Public Policy, American Association for the Advancement of Science AAAS ; National Conference, St. Louis, MO, February 17, 2006. The other panelists in attendance, representing a broad range of opinion, concurred or did not challenge her assessment. They were Katherine Flegal of the Centers for Disease Control and Prevention, and the National Center for Health Statistics; Frank Hu of Harvard University; William Harlan of the National Institute of Mental Health and Mitch Gail of the National Cancer Institute and ofloxacin.
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Hepatic insufficiency ezetimibe after a single 10-mg dose of ezetimibe, the mean exposure based on area under the curve ; to total ezetimibe was increased approximately 7-fold in patients with mild hepatic insufficiency child-pugh score 5 to 6 ; , compared to healthy subjects and felodipine.
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Ulrike Koch, David Daz-Carballo, Siegfried Seeber, Ralf A. Hilger Department of Internal Medicine Cancer Research ; , University of Essen Medical School, West German Cancer Center, Essen Introduction: We have characterized a polyisoprenylated benzophenone isolated from Clusia rosea, collected in Florida, USA. This novel substance, called CLU-502, was isolated from methanolic extracts of the plant using RP-HPLC coupled to a PDA-detector. CLU-502 has shown potent cytotoxic activity in a panel of human tumor cell lines such as breast, colon, stomach, ovarian, prostate, neuroblastoma and leukemia lines. Both, wild-type cells and cells resistant to cytostatic therapy with doxorubicin Adriamycin ; , cis-platinum, etoposide Vepesid, VP-16 ; , SN-38 the active metabolite of CPT-11 CAMPTOSAR, Irinotecan ; , raltitrexed Tomudex ; or 5-fluorouracil are highly sensitive to CLU-502. Initial toxicological studies in nude mice revealed that treatment with CLU-502 was well tolerated up to 100 mg kg. Purpose: The present study has conducted to analyze the anti-tumoral activity of CLU-502 on the growth of human neuroblastoma SKNAS ; , of colon cancer HCT-8 ; as well as prostate cancer PC3 ; transplanted into NMRI nu nu mice. Methods: In a first set of toxicological experiments in NMRI nu nu mice, the MTD of CLU-502 was defined to 100 mg kg body weight in a daily intra peritoneal i.p. ; treatment schedule. Effectivity of CLU502 against colon carcinoma was analyzed at half of the MTD 50 mg kg body weight ; and in neuroblastoma at the MTD of CLU-502 in subcutaneous xenograft models. In addition, an orthotopic xenograft model was chosen for testing activity against prostate cancer at the MTD. The treatment of the colon cancer group was performed i.p. for seven days on a daily base. In the neuroblastoma groups, daily drug application was performed either i.p. or oral at a dose of 100 mg kg body weight. Treatment duration in these groups was 14 days. Results: Using the subcutaneous xenograft model, tumor growth inhibition was obtained after oral as well as i.p. application of CLU-502 compared to the control groups. The evaluation of efficacy of CLU502 in the orthotopic xenograft model is not completed up to know. Conclusions: The polyisoprenylated benzophenone CLU-502 is active against a panel of human tumor cell lines in vitro and against the colon cancer cell line HCT-8 as well as the neuroblastoma cell line SKNAS in vivo. The efficacy after oral application demonstrated at least in part bioavailability of the drug. Further experiments regarding pharmacokinetics as well as efficacy are on the way.
Pathogenesis of idiopathic CaOx stones Stones form on interstitial apatite plaque 19 ; stonesformed, varies directlywithplaquesurfacecoverage 20 ; , aswouldbeexpectedif Plaque begins in the basement membranes of the thin Henle loops.Basementmembrane BM ; Figure1, AandB the Figure1, BandC ; . intheinterstitium and
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Annual Review 1. Discussion a. b. c. General health and well-being Blood pressure and cardio-vascular risk Glycaemic control, hypos and awareness thereof Knowledge of diabetes and self-management Smoking, alcohol, exercise Complications Sick day rules Contraception Sharps disposal.
The evidence suggests that patient self-monitoring of oral anticoagulation is more effective in terms of patient satisfaction than supervised management.313 However, the results of such trials should be interpreted carefully. Many studies were conducted using a motivated patient population who were selected using strict inclusion criteria, which often included passing a cognitive test. In one study307 the authors report that although at the end of the study period many patients wished to continue self-monitoring, this required sufficient personal financial resource to fund the purchase of the necessary equipment. There was a difference in the cost effectiveness depending on whether patient and carer costs were included with medical costs. Further data based on the UK health setting would be required in order to determine the cost effectiveness of self-monitoring. A recent non-commercially funded trial325 which was published too late to be included in the above review, showed self-monitoring to be safe and effective in a UK population. This conclusion is consistent with the results from smaller trials above, most of which received commercial backing. Increasing the adoption of self-monitoring might lead to additional pressure on GP services. It was considered that the use of self-monitoring needs to be balanced between patient preference and the ability of local services to provide support eg patient education programmes ; . It was noted that guidelines have been published in the area of patient self-monitoring of oral anticoagulation.326 These recommend that patients undertaking anticoagulation selfmonitoring should be trained by a competent healthcare professional and remain in contact with a named clinician. They also highlight the need for self-monitoring devices that have been adequately quality-assured.
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Elaine will ask Jessica Duke about Oregon's response to HIV prophylaxis. * Gretchen will bring her algorithm from SF. We will create something for the medical guideline from the new CDC 2006 Guidelines. * Cindy will talk to Shawn Shaffer. Our job algorithm, guidelines, resources and recommendations. At least talk to people about their risk. Educate the providers so they can educate the patients. Update on Policy Issues SAVE Fund need assistance Jennifer Stephans and Makenzy Byrum agreed to work on this with Elaine. Recertification Requirements corrections announced. Updated requirements will be on the website within the next week and nurses will be notified. Creating a Standard Chart Consents brainstorm about what it needs to include ; : Evidence collection Photo documentation Release to LEA DA Interview Education peer review Vague consents with regard to evidence collection No list w check boxes.just include topics in consent statement Refer to U of consent Need section added to U of prototype for specific photo consent Possible release of info to specific LEA DA Separate medical and legal authorizations Consents need to apply to both complete and partial exams Side conversation regarding using sexual assault paperwork for all exams including partials the Task Force MFC recommends using SA forms to document all cases, not just `complete'. ; There is a question about whether the form needs to come to the full Task Force or whether the committee can approve the form and send it out to nurses. The group recommended that there be a place to document EC STI Prophylaxis offered? yes but is in discussion about whether the reasons for declining should be included on the SA form or only in medical information. General discussion about the need to separate nonrelated medical information and private medical information from the SA documentation. The group will continue to work on the chart at the next meeting, for example, drugs.
Drugs by name drugs by condition drugs by category most searched active ingredients fda alerts vepeaid etoposide ; - warnings and precautions summary description clinical pharmacology indications and dosage warnings and precautions side effects and adverse reactions drug interactions overdosage and contraindications other rx information active ingredients news in media published studies curr't clinical trials - advertisement - warnings vepeesid etoposide ; should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents and famciclovir.
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TOXSCI-05-0664-Revised Supplemental Data. Genes differentially expressed in LPS RAN-treated rats compared to other treatment groups is shown in Supplemental table 1. Supplemental Tables 2-8 contain genes displayed in Venn diagram format in Figure 6. Supplemental Table 9 contains genes differentially expressed in LPS RAN-treated rats as a consequence of a RAN effect. Statistical filters applied to generate these lists are described in the results section. Supplemental data are available for download at toxsci.oupjournals.
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SNP ; and by the physicians as a Physician Treatment Guideline. Appendix 2 & 3 ; This has provided improved management of cellulitis and wound infections in the jail system. Patients are receiving treatment in a more timely fashion, treatment is appropriate for the organism, healing time has improved, and this is cost effective. The period of treatment is shortened, the number of medications has reduced, and the number of inmate patients developing cellulitis or infections while in custody has been reduced. Appendix 4 ; SNP compliance by its nature has been 99%, the exception being where there has been a delay in the initiation of the SNP. Physician guideline compliance is good and improving. There has been strong support from those in authority. Full embracing of the protocol is an educational issue and will require ongoing monitoring. Surveillance is the foundation of infection control. The above protocols are based on the data collected through meticulous and time consuming evaluation of the medical records of those who have developed wound infections while in custody or who have come into the system with pre-existing conditions and wound infections. Risk factors of patients presenting with cellulitis have been reviewed and documented. Wound culture reports and antibiograms have been evaluated in the effort to effect appropriate effective wound management and treatment. Appendix 5 ; Appendix 6 ; Prevention is the last piece of the picture. Due to the nature of the jail system one cannot prevent all cases of wound infection and cellulitis. Many inmates will continue to enter the system with pre-existing conditions. Furthermore, there is a portion of the population who are carriers of the Staph bacilli without disease and are therefore colonized and can spread the bacilli to those who are vulnerable. CA-MRSA is a phenomenon that is not going to disappear and has spread worldwide. The best that can be expected is to control transmission within the jail system, treat all cellulitis efficiently and appropriately and educate staff and inmates concerning transmission, prevention and prompt reporting. Appendix 7 ; Cleanliness and hand washing will continue to be the first line of defense against bacteria and the pathogenic process. The future plan in the San Diego jail system is for continued surveillance and assessment with a goal of the reduction of MRSA transmission in the jails and the prompt resolution of infections through early identification, intervention and appropriate, effective treatment of all soft tissue wounds, for instance, etoposide vepesid.
POOL KD, DEVOUS MD, FREEMAN FJ, WATSON BC, FINITZO T: Regional cerebral blood flow in developmental stutterers. Arch. Neurol. 1991 ; 48: 509-512. NUDELMAN HB, HERBRICH KE, HESS KR, HOYT BD, ROSENFIELD DB: A model of the phonatory response time of stutterers and fluent speakers to frequency-modulated tones. J. Acoust. Soc. Am. 1992 ; 92 4 Pt 1882-1888. NEUMANN K, EULER H, VON GUDENBERG W et al.: The nature and treament of stuttering as revealed by fMRI A within- and between-group comparison. J. Fluency Disorders 2003 ; 28: 381-410. BURD L, KERBESHIAN J: Stuttering and stimulants [letter]. J. Clin. Psychopharmacol. 1991 ; 11 1 ; : 72-73. MAGUIRE GA: The dopamine hypothesis of stuttering and its treatment implications. Presented at Collegium Internationale NeuroPsychopharmacologicum, Brussels, Belgium, July 2000 ; . FOUNDAS AL, BOLLICH AM, COREY DM, HURLEY M, HEILMAN KM: Anomalous anatomy of speech-language areas in adults with persistent developmental stuttering. Neurology 2001 ; 57: 207-215. SOMMER M, KOCH MA, PAULUS W, WEILLER C, BUCHEL C: Disconnection of speech-relevant brain areas in persistent developmental stuttering. Lancet 2002 ; 360: 380-383. RILEY G: Stuttering severity instrument 3rd edn ; . ProEd, Austin 1994 ; . BAKKER K, RILEY G: 1994 ; . Computerized Scoring of Stuttering Severity. Austin, TX ProEd.
Corresponding author. Johns Hopkins Bayview Medical Center, Department of Neurology, 4940 Eastern Avenue, Baltimore, MD 21224. Fax: 1-410-550-0539. E-mail address: kbolla jhmi K.I. Bolla.
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Though most of the private practitioners, 321 94.4% ; , would like to be provided with information about national tuberculosis control programme only 89 26.2% ; of them had ever participated in a continued medical education programme on TB treatment or control within the past 5 years. Discussion Tuberculosis control is one of the many public health challenges for which innovative approaches to public-private partnership are being sought. This is partly because the private health sector is often the first point of contact for many patients with tuberculosis. Although the present study showed that only a small proportion 18.8% ; of private practitioners managed more than five TB cases per month, studies elsewhere indicate that private practitioners manage reasonably high number of tuberculosis cases. Uplekar et al., 2001 ; . The later study in India noted that 60% of individuals with a longstanding cough first went to a private practitioner Uplekar et al., 2001 ; . Indeed evidence shows that in many low-income countries much of the populations across all socio-economic strata are known to turn to individual or institutional private health care providers Bennett, 1991 ; . Preference of some tuberculosis patients to private practitioners may be because they are often located close to and are often trusted by the community. Since a reasonable number of tuberculosis patients are first treated by private practitioners, many agencies like the World Health Organization, have tried scrutinizing the diagnostic criteria and treatment of these cases by the private practitioners with the aim of improving tuberculosis management, hence the establishment of the public-private mix. In fact, all of the published studies from Asia and many other parts of the developing countries have identified important shortcomings in diagnosis of tuberculosis cases by the private practitioners Uplekar & Sheperd, 1991; Hong et al., 1995; Marsh et al., 1996 ; . In a previous study, despite the well-established fact that depending just on only chest radiograph for diagnosis of tuberculosis is unreliable due to it's likelihood to show false positive and false negative results yet a larger proportion of private practitioners depended on chest radiograph alone for diagnosis. Fortunately, in present study most private practitioners included sputum AFB result as part of diagnosis. The dependence on sputum AFB in present study may be because of increased awareness of private practitioners on the need for a sputum smear positive result for diagnosis. Another shortcoming of private practitioners is in treatment of tuberculosis cases.
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