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Framin protein see Fig. 1 ; . Of the four nonsense mutations, three were identified for the first time and one E752X ; has been reported previously in a British patient 20 ; . The three novel mutations were distributed across the entire gene. Intriguingly, the E864X mutation removed the last 26 amino acids of the protein, implying that this section of the protein is important for its function. The remaining missense changes all occurred in exon 8 and are presumed to affect the function of the protein. A series of silent polymorphisms, most of which have been identified previously, were also present in the patient series reported herein. Because 53% were identified multiple times, they were considered to be common polymorphisms that did not affect protein function, even if they were associated with amino acid changes. The remaining rare polymorphisms and those that have not been identified previously are problematic because they cannot be unequivocally determined as causative. Until a functional assay is established to assess these polymorphisms, they should be considered suspicious. One of the striking features of our clinical series is the severity of the phenotype in two families. We have defined "severe" as the development of neurodeDIABETES CARE, VOLUME 27, NUMBER 8, AUGUST 2004, because vermox side effects.
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B.A. Prakash, who has studied Indian migration to Gulf countries during the past two decades, notes that emigration of Indians to the Gulf divides in four stages: 1. 1976-1979: Beginning of out-migration. 2. 1980-1983: Rapid growth. 3. 1984-1990: Declining growth. 4. 1991-1994: Revival and intensified growth.12 Data from the Indian Ministry of Labor support Prakash's migration typology. Moreover, the steadily rising stock of Indian workers in the Gulf imply that outmigration from the region slows when in-migration falters. This synchronicity of labor import and export has resulted in a steady rise in the pool of Indian migrants to the Gulf during the last two decades Tables 5 and 6.
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