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The usual effective maintenance dosage is 20 mg administered in a single daily dose. In general if the desired therapeutic effect cannot be achieved in a period of 2 to weeks on a certain dose level, the dose can be further increased. The maximum dose used in long-term, controlled clinical trials was 80 mg day. Diuretic -Treated Patients Symptomatic hypotension may occur following initiation of therapy with Zestril. This is more likely in patients who are being treated currently with diuretics. Caution is recommended therefore, since these patients may be volume and or salt depleted. If possible, the diuretic should be discontinued 2 to 3 days before beginning therapy with Zestril. In hypertensive patients in whom the diuretic cannot be discontinued, therapy with Zestrul should be initiated with a 5 mg dose. Renal function and serum potassium should be monitored. The subsequent dosage of Zesttil should be adjusted according to blood pressure response. If required, diuretic therapy may be resumed see section 4.4 and section 4.5 ; . Dosage Adjustment In Renal Impairment Dosage in patients with renal impairment should be based on creatinine clearance as outlined in Table 1 below.
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Call to Order The meeting was called to order by President Mike Frontz at 8: November 8, 2002. He welcomed everyone to Galveston and introduced our host, Lori Speaker. Lori welcomed everybody to Galveston and mentioned that there were about 70 people in attendance along with 11 vendors. She encouraged those attending who are not members to join the organization. She ended by thanking everyone for their help. Secretary's Report Secretary Kathy Erwin made a motion to accept the minutes from the Wichita meeting as written in the newsletter. It was seconded by Rod McCutcheon and approved. Treasurer's Report Treasurer Robert Schoenfeld presented his report. As of October 23, 2002, our total net worth is $15, 619.45 with the Bank Book Balance at $9, 206.45 and the Fidelity Funds Balance at $6, 413.00. A motion was made that we accept the treasurer's report. It was seconded and approved. Committee Reports A. Meeting Grants Chris Heartsill reported that one meeting grant application was submitted for Monica Lopez, who is presenting a paper on "Toluene Artifact in a Medical Examiner Case". The board approved that Monica Lopez be granted the standard $300 award for being in a nonsupervisory position and presenting a paper. The board also approved deferring the award until the Albuquerque meeting as Monica requested. Chris also encouraged members to apply for meeting grants as SAT is able to grant 2 per meeting. B. Membership Councilor Phil Kemp presented the report. Brenda Snodgrass and the two councilors, Phil Kemp and Brad Hall, who make up the Membership Committee, recommended that the board present the following four applicants to the general membership for approval. They are: Colleen Corcoran, Orleans Parish Coroner's Office, New Orleans, LA Jay Hoppenwasser, Sam Houston State University, Huntsville, TX Denise Mire, Orleans Parish Coroner's Office, New Orleans, LA Kelsie Simons, Sam Houston State University, Huntsville, TX Mike Carlo moved that we accept all four applicants for membership. It was seconded by John Tarver and approved.
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JPET #124768 In this study, we use a global approach to determine the physicochemical properties necessary for drug binding to BCRP. A dataset of 123 compounds spanning the entire structural space of registered drugs was studied for the inhibition of BCRPmediated mitoxantrone efflux in Saos-2 cells transfected with human wild-type Arg482 ; BCRP Wierdl et al., 2003 ; , resulting in the discovery of 29 previously unknown BCRP inhibitors. An easily interpreted computational model was developed that is capable of discriminating inhibitors from non-inhibitors based on structural features related both to the drug's capacity to insert into the cell membrane and to interact with the inhibitory binding site of the transporter. The results were supported by a global pharmacophore model and are in agreement with a two step mechanism for inhibition of BCRP.
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Be noted in text. It is the author's responsibility to obtain permission to refer to another individual's unpublished observations. Manuscripts that are actually "in press" may be cited as such in the reference list; the name of the journal or publisher and location must be included. Type references in the style shown below, double-spaced throughout. List up to three authors; designate one or more authors past the third as "et al." Abbreviations of journal names should conform to the style used in Index Medicus; journals not indexed there should not be abbreviated.

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