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Differential expression of hepatic oestrogen, phenol and dehydroepiandrosterone sulphotransferases in genetically obese diabetic ob ob ; male and female mice. Borthwick EB, Burchell A, Coughtrie MW Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, UK. J Endocrinol 1995 Jan; 144 1 ; : 31-7 Sulphotransferases STs ; are a family of closely related enzymes playing a key role in regulation of the bioavailability and activity of important endogenous molecules such as steroid hormones. A relationship between the expression of steroid STs and the diabetic state has been demonstrated in various laboratory animal models, and steroid sulphates such as dehydroepiandrosterone sulphate are 540.
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Introduction REVEAL is a patient activated implantable loop recorder available to assist in the diagnosis of syncope or arrhythmias. We present our experience using this device in older subjects referred to a dedicated falls and syncope clinic in whom usual clinical assessment had not satisfactorily identified an attributable diagnosis but were a cardiovascular cause for syncope or falls was still suspected. Methods Subjects, over the age of 60 years, who had implantation of REVEAL between 1997 and April 2001 for investigation of syncope or unexplained falls were identified. Medical case notes were reviewed retrospectively. Results 15 subjects had REVEAL implanted between 1997 and 2001. The mean age was 73 years range 61-89 ; , 87 % being female. Despite extensive investigation including active stand, carotid sinus massage on at least one occasion, passive tilt testing and in the majority of cases GTN provocation tilt testing an attributable cause of syncope or falls was not found. Subjects were referred for implantation of REVEAL after a mean of 5 months range 1-13 months ; . Of the 15 subjects 7 have activated the device with significant arrhythmias being present in 4 3 bradycardia or asystole, 1 ventricular tachycardia ; . Time to activation was short at 4 months. Six people have not yet activated the device mean duration of follow up 5 months ; . Two subjects did not activate the device during the 18 months it was insitu. Conclusion REVEAL offers additional diagnostic yield in complex elderly subjects with suspected cardiovascular causes of syncope or unexplained falls which have not been previously satisfactorily diagnosed despite extensive investigations. The KNAW report suggests a number of criteria and indicators: 1 ; mission of the research group, 2 ; global profile of the group, 3 ; input, output and mobility of the researchers, 4 ; impact of the scientific work in terms of scientific publications, and 5 ; socio-economic performance. Here, the assessment of the societal impact is focussed on the criteria 2 ; and 5 ; , whereas the mission criterium 1 ; is reviewed in the light of both scientific and societal challenges in the field. The other criteria are discussed elsewhere in the present report. The KNAW report furthermore states that: 1. Pilot reviews of institutes for applied health research have to be carried out in order to fully develop the methodology and its application Comment: to date only a few of such reviews have taken place with the most recent one carried out by sci-Quest Research Network for Science & Technology Policy, Amsterdam-Maarsen ; at the request of UIPS and GUIDE GRIP. Although a number of approaches appear well suited and have been adopted by GUIDE FMS as detailed below, it was concluded that there is as of yet no general, validated methodology available. 2. `The research mission is indicative for how and to what extent the societal impact of the research should be evaluated. The mission should be reviewed in the light of both scientific and societal challenges in the field. Comment: this point is an important qualifier that will be illustrated below, i.e. per program in the results section of this paragraph A.7.2.3 ; . A.7.2.2 Methodology In light of the limitations indicated above no fully developed methodology available ; , GUIDE FMS organised a self- ; assessment of the societal relevance of its research programs. 26 Dr. M.H.W. Hooiveld , a former staff member of the Council for Medical Sciences of the KNAW and one of the authors of the above mentioned report, was contacted to assist in the development of a suitable evaluation procedure. The developed procedure for ex post assessing the global profile of a research group and the so-called `Socio-Economic Impact' SEI, i.e. the relations to and or collaborations with industry, non-profit organisations and society ; of its research programs was subsequently applied. The selected items appendix IIIa ; were addressed by the assessment appendix IIIc ; in a similar way as done by sci-Quest Amsterdam-Maarsen ; in their assessment of GUIDE GRIP, but with a number of important modifications to make it more manageable and to adapt the assessment to the area of medical research. The information required for the assessment was obtained via an extended questionnaire see appendix IIIb ; to evaluate the global profile and the socio-economic impact in three different social domains: 1 ; academic, 2 ; industry and 3 ; society. A team of semi- ; independent interviewers consisting of faculty support staff ; used this questionnaire to interview selected, representative researchers of the programs the number depending on the size of the program ; . Based on the results, a semi-quantitative embedment profile of the societal impact ; of the research groups was generated, because zovirax acyclovir ointment 5.

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There is a Proposed Settlement with SmithKline Beecham Corporation, doing business as GlaxoSmithKline "GSK" ; , one of the Defendants in a class action lawsuit pending in the U.S. District Court for the District of Massachusetts. The name of the lawsuit is In Pharmaceutical Industry Average Wholesale Price Litigation, Docket No. 01-CV-12257-PBS, MDL No. 1456. The lawsuit claims that certain drug companies reported false and inflated average wholesale prices "AWP" ; for certain types of outpatient drugs. The reported AWPs are used to set prescription drug prices that are paid by Medicare, consumers and insurers. The lawsuit asks the Court to award money damages to some people who paid or made co-payments for the drugs. GSK has entered into a Proposed Settlement with the Plaintiffs and has agreed to pay $70 million to settle their claims and other related claims. After payment to certain State Attorneys General of $4.5 million, and after deducting attorneys' fees and costs of administering the Proposed Settlement, 30% of the net fund will be distributed in cash to consumers who paid for all or part of the cost of the drugs and who submit a valid claim form. The GSK Covered Drugs fall into two categories, as follows: The "Category A" Drugs, namely Kytril Injectable and Zofran Injectable, and the "Category B" Drugs, namely Alkeran, Imitrex, Kytril tablets ; , Lanoxin, Myleran, Navelbine, Retrovir, Ventolin, Zofran orals ; , Zovvirax and Zantac. A complete list of the GSK Covered Drugs, including formulations, is set forth in the response to Question 8 below. There are two sub-Classes for individual consumers who paid for the GSK Covered Drugs. You are a member of Medicare Co-Payment Class if: You made or are currently obligated to make a percentage co-payment under Medicare Part B for any of the. The decision to prescribe antibiotics is not clear cut in many common infections as the vast majority of common ailments are of viral origin and are unaffected by antibiotics. Nonetheless studies have shown that the clinician's approach to drug prescription is coloured by the patient's expectation that antibiotics are good for them. Such unnecessary prescription aggravates the selection of resistance strains. Thus, campaigns to eliminate antibiotic abuse should be targeted not only towards clinicians but also the general public as well as the pharmaceutical industry. Prescription of an antimicrobial is therefore a serious step similar to the prescription of a steroid or any other potentially hazardous medicament and alesse and zovirax, for example, zoirax tabletten.

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APPENDIX Contrasting Patterns of Correlations--Four Classes of Seniors 1985-88 ; Versus Thirteen 1976-88 ; Our earlier analysis of factors linked to the decline in marijuana use made use of eleven classes of seniors 1976-86 ; , and we have now extended that analysis to include two more classes. For reasons discussed in the text, the present analysis of factors linked to the decline in cocaine use focuses primarily on a shorter interval encompassing the classes of 1985-88 ; . This appendix presents correlation matrices for both intervals, reviews differences and similarities ; in results, and discusses some implications of the differences. There are several reasons for expecting that some of the correlations will differ across the two intervals. First, we have noted important secular trends in use of both marijuana and cocaine during the period in question, and such trends introduce additional variance which will tend to reduce correlations with other factors--unless those factors show parallel secular trends. Second, shifts in drug use rates from year to year usually also involve shifts in variance, which in turn can influence the size of correlations. For example, during the late seventies relatively few high school seniors used cocaine, and correlations involving cocaine use in the years 1976 through 1978 were lower than correlations in the early eighties when more seniors used cocaine ; . For marijuana, on the other hand, mean levels of use have declined since the late seventies, and there has been a corresponding decline in overall variance and in the size of most correlations involving marijuana see Bachman et al. 1986, for details on such trends in correlations, comparing each graduating class from 1975 through 1986 ; . We turn now to a number of specific comparisons of correlations based on the two intervals; we also include a few comments about correlations for the dataset spanning 1980-88 although the matrix is not included in this appendix ; : 1. Individual reports of cocaine use and marijuana use are substantially correlated, but the relationship is stronger when we confine our attention to seniors from the classes of 1985-88 r .50 ; rather than the longer interval of 1976-88 r .44 ; . For the dataset spanning 1980-88, the correlation value is intermediate r .48. ; This difference in correlations very likely reflects both factors discussed above. First, the secular trends for both marijuana and cocaine use are similar in direction both downward ; for the period 1985-88, whereas that is not true for earlier years. Second, cocaine variance is slightly larger for the 1985-88 dataset; and although marijuana variance is distinctly smaller for this shorter interval, the distributions for the two variables are less disparate during recent years, thus making possible a higher correlation. 2. The similarity in secular trends for marijuana and cocaine use during the 1985-88 interval is clearly evidenced by the correlation between the, because zovirax chicken pox. Abbreviation: NI, not included in multivariate model. * Numbers of cases and controls with various illnesses are shown in Table 2. Data are odds ratio 95% confidence interval ; . Multivariate analysis adjusts for presence of other predictive illnesses from univariate analysis and zyban.
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