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Published by the Publications Sub-group to reflect the views of the Area Drug & Therapeutics Committee but not necessarily those of Greater Glasgow Health Board. GGHB Area Drug & Therapeutics Committee June 2000 Design, layout and production control: Strathcashel Publications Project Management 01505 850 344 ; Printed by: Joint Universities Design and Print Unit, Glasgow.
Cyclophosphamide cyclosporine CYKLOKAPRON CYMBALTA CYOTIC cyproheptadine hydrochloride CYSTADANE CYSTAGON CYSTOSPAZ CYSTOSPAZ-M CYTADREN cytarabine CYTOMEL CYTOTEC CYTOVENE CYTOXAN CYTRA K CRYSTALS CYTRA-2 CYTRA-3 CYTRA-K D.H.E. 45 dacarbazine DACOGEN DALLERGY DALLERGY JR D-AMINE-SR danazol DANTRIUM dantrolene sodium dapsone DAPTACEL DARAPRIM DARVOCET DARVOCET-N DARVON DARVON COMPOUND DARVON-N daunorubicin hydrochloride 35 122 49 DAUNOXOME DAYPRO DAYTRANA DDAVP DEBACTEROL DECADRON DECAVAC DECLOMYCIN DECON-A DECONAMINE SR DECON-E DECONEX DECONGEST II DECONGESTINE TR DECONSAL CT CHEW DECONSAL II DEHISTINE DEL-AQUA DEL-BETA DELESTROGEN DELTASONE DEMADEX demeclocycline hydrochloride DEMEROL DEMSER DEMULEN DENAVIR DENAZE DENTA 5000 PLUS DENTAGEL DENTALL 1100 PLUS DEPACON DEPADE DEPAKENE DEPAKOTE ER DEPAKOTE SPRINKLES DEPEN TITRATABS DEPODUR 35 43 47.
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Detection of cyp and efflux transporter mRNA levels. In both strains, the major cyp isoforms present in liver tissues were cyp1a2 and cyp3a11, whereas cyp1a1 and cyp2b10 were predominantly expressed in the upper part of the intestinal tract Table 4 ; . The expression levels of cyp1a1, cyp1a2, cyp2b10 and cyp3a11 by kidney, colon and adrenal glands were low or even absent Table 4 ; . The efflux transporter mdr1a was highly expressed in adrenal glands and in the intestinal tract of both strains and levels increased from duodenum towards colon Table 5 ; . In the kidney the major transporters present were mrp1 and mrp2, whereas in the liver, mrp2 was expressed at significant levels. Mdr1b is highly detected in the adrenal glands Table 5 ; . The cyp and transporter mRNA expression profiles for both strains in all organs evaluated were very similar. The only significant difference between species was observed with respect to cyp1a1, which was found to be expressed 3 times higher in the duodenum of nude mice.
Being located just beneath the epidermal basement membrane, the subepidermal nervous plexus is enveloping our whole body surface. It is the most distal part of the nervous system still containing a schwann cell sheath around the delicate nerve fibers enabling uncomplicated access to the peripheral nervous system. As we were interested in the ultrastructure of its fibers, we did immunohistochemical stainings with Nerve Growth Factor receptor antibody on horizontal sections of papillary dermis and performed electron microscopy thereof. A total of 9 sections containing 61 nerve fibers were analysed in detail. The thickness of the single nerve fibers ranged from 1.244nm to 35.303nm with a median diameter of 4.737nm. The median axon number ensheathed per Schwann cell was 2 with a range from 1 to 27. Axon diameter ranged from 197nm to 1.925nm with a median caliber of 610nm. In approximately 15% of the axons, the Schwann cell sheath was found to be incomplete, only invaginating one part of the axon, allowing the other part to be closely associated with the extracellular space. All of the nerve fibers found were unmyelinated. Strikingly, 5 nerve fibers contained each one axon which was wrapped by two or three layers of the mesaxon beside further axons, which were wrapped by only one layer of mesaxon. Potentially, this rudimental multi-layered sheath depicts the beginning of myelination in the periphery. However, myelinated and unmyelinated axons have never been shown to occur in one Schwann cell. In conclusion, we were able to provide morphological data being useful in the further evaluation of physiological and pathological changes of the superficial dermal nerve plexus. This is of importance as only few ultrastructural descriptions of the nerve fibers in the subepidermal nerve plexus are available and as skin biopsies are increasingly discovered an exciting tool to evaluate peripheral neuropathies and tolterodine.
Peacock SJ, de Silva I, Lowy FD. 2001. What determines nasal carriage of Staphylococcus aureus ? Trends Microbiol 9: 605610. Rao GG. 1998. Risk factors for the spread of antibiotic resistant bacteria. Drugs 55: 323330. Roberts K, Hathway A, Fletcher LA, Beggs CB, Elliot MW, Sleigh PA. 2006. Bioaerosol production on a respiratory ward. Indoor Built Environ 15: 135140. Roy CJ, Milton DK. 2004. Airborne transmission of communicable infection the elusive pathway. New Engl J Med 350: 17101712. Salgado CD, Farr BM, Calfee DP. 2003. Community-acquired methicilliin-resistant Staphylococcus aureus : a metaanalysis of prevalence and risk factors. Clin Infect Dis 36: 131139. Smith RD, Coast J. 2002. Antimicrobial resistance: a global response. Bull WHO 80: 126133. Sterling DA, Lewis RD. 1998. Pollen and fungal spores indoor and outdoor of mobile homes. Ann Allergy Asthma Immunol 80: 279285. Virk A, Steckelberg JM. 2000. Clinical aspects of antimicrobial resistance. Mayo Clin Proc 75: 200214. Wagenvoort JHT, Davies BI, Westerman EJA, Werink TJ, Toenbreker HMJ. 1993. MRSA from air-exhaust channels. Lancet 341: 840841.
Table 2. Absence of antagoni8m of dihydroergotamine by adrenaline, and of ly8ergic acid diethylamide by 8erotonin and gliclazide.
D.H.E.45 DALLERGY DALMANE DANOCRINE DANTRIUM DARVOCET-N DARVON DAYPRO DDAVP DECADRON DECLOMYCIN DECONAMINE DECONAMINE SR DECONSAL II DELATESTRYL DELESTROGEN DEMADEX DEMEROL DEMULEN DEPAKENE DEPO-MEDROL DEPO-PROVERA DEPO-TESTOSTERONE DESOGEN DESOWEN DESOXYN DESQUAM-E DESQUAM-X DESYREL DEXEDRINE DEXTROSTAT DIABETA DIABINESE DIAMOX DIFLUCAN DILACOR XR DILANTIN DILANTIN-125 DILAUDID DIPROLENE DIPROLENE AF DIPROSONE DISALCID DITROPAN.
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Hormone-releasing hormone signaling: a role for transforming growth factor-beta 1. Biol Reprod 2000; 62: 17101721. Azcoitia I, Sierra A, Garcia-Segura LM. Localization of estrogen receptor- immunoreactivity in astrocytes of the adult rat brain. Glia 1999; 26: 260267. Santagati S, Melcangi RC, Celotti F, Martini L, Maggi A. Estrogen receptor is expressed in different types of glial cells in culture. J Neurochem 1994; 63: 20582064. Bruno V, Battaglia G, Casabona G, Copani A, Caciagli F, Nicoletti F. Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta. J Neurosci 1998; 18: 95949600. Prehn JH, Bindokas VP, Marcuccilli CJ, Krajewski S, Reed JC, Miller RJ. Regulation of neuronal Bcl-2 protein expression and calcium homeostasis by transforming growth factor beta confers wide-ranging protection on rat hippocampal neurons. Proc Natl Acad Sci U S A 1994; 91: 1259912603. Prehn JH, Bindokas VP, Jordan J, Galindo MF, Ghadge GD, Roos RP, Boise LH, Thompson CB, Krajewski S, Reed JC, Miller RJ. Protective effect of transforming growth factor beta1 on beta-amyloid neurotoxicity in rat hippocampal neurons. Mol Pharmacol 1996; 49: 319328. Ren RF, Flanders KC. Transforming growth factor beta protects primary rat hippocampal neuronal cultures from degeneration induced by beta-amyloid peptide. Brain Res 1996; 732: 1624. Ren RF, Hawver DB, Kim RS, Flanders KC. Transforming growth factor beta protects human hNT cells from degeneration induced by beta-amyloid peptide: involvement of the TGF-beta type II receptor. Brain Res Mol Brain Res 1997; 48: 315322.
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Makeig, S., Townsend, J., Jung, T.-P., Enghoff, S., Gibson, C., Sejnwoski, T. J., & Courchesne, E. 1999 ; . Early visual evoked response peaks appear to be sums of activity in multiple alpha sources. Soc. Neurosci. Abstr., 25 652.8 ; . Makeig, S., Wester eld, M., Jung, T.-P., Covington, J., Townsend, J., Sejnwoski, T. J., & Courchesne, E. 1999 ; . Functionally independent components of the late positive event-related potential during visual spatial attention. J. Neurosci., 19 7 ; , 26652680. Makeig, S., Wester eld, M., Townsend, J., Jung, T.-P., Courchesne, E., & Sejnowski, T. J. 1999 ; . Functionally independent components of the early eventrelated potential in a visual spatial attention task. Philosophical Transactions of the Royal Society: Biological Sciences, 354, 11351144. Mosher, J. C., & Leahy, R. M. 1998 ; . Recursive music: A framework for EEG and MEG source localization. IEEE Transactions on Biomedical Engineering, 45 11 ; , 13421354. Mosher, J. C., & Leahy, R. M. 1999 ; . Source localization using recursively applied projected RAP ; MUSIC. IEEE Transactions on Signal Processing, 47 2 ; , 332340. Mosher, J. C., Lewis, P. S., & Leahy, R. M. 1992 ; . Multiple dipole modeling and localization from spatiotemporal MEG data. IEEE Transactions on Biomedical Engineering, 39 6 ; , 541557. Nagano, T., Ohno, Y., Uesugi, N., Ikeda, H., Ishiyama, A., & Kasai, N. 1998 ; . Multi-source localization by genetic algorithm using MEG. IEEE Transactions on Magnetics, 34 5 pt.1 ; , 29762979. Pearlmutter, B. A., & Parra, L. C. 1996 ; . A context-sensitive generalizatio n of ICA. In International Conference on Neural Information Processing pp. 151157 ; . Hong Kong: Springer-Verlag. Ribary, U., Ioannides, A. A., Singh, K. D., Hasson, R., Bolton, J. P. R., Lado, F., Mogilner, A., & Llinas, R. 1991 ; . Magnetic- eld tomography of coherent thalamocortical 40-Hz oscillations in humans. Proc. Natl. Acad. Sci. USA, 88 24 ; , 1103711041. Schmidt, D. M., George, J. S., & Wood, C. C. 1999 ; . Bayesian inference applied to the electromagnetic inverse problem. Human Brain Mapping, 7 3 ; , 195212. Schwartz, D. P., Badier, J. M., Bihoue, P., & Bouliou, A. 1999 ; . Evaluation of a new MEGEEG spatio-temporal localization approach using a realistic source model. Brain Topogr., 11 4 ; , 279289. Sekihara, K., Nagarajan , S. S., Poeppel, D., Miyauchi, S., Fujimaki, N., Koizumi, H., & Miyashita, Y. 2000 ; . Estimating neural sources from each timefrequency component of magnetoencephalographi c data. IEEE Transactions on Biomedical Engineering, 47 5 ; , 642653. Sekihara, K., Poeppel, D., Marantz, A., Koizumi, H., & Miyashita, Y. 1997 ; . Noise covariance incorporated MEG-MUSIC algorithm: A method for multipledipole estimation tolerant of the in uence of background brain activity. IEEE Transactions on Biomedical Engineering, 44 9 ; , 839847. Tang, A. C., Pearlmutter, B. A., Zibulevsky, M., & Carter, S. A. 2000 ; . Blind separation of multichannel neuromagnetic responses. Neurocomputing, 32 33, 11151120. Tang, A. C., Pearlmutter, B. A., Zibulevsky, M., Hely, T. A., & Weisend, M. P. 2000 ; . An MEG study of response latency and variability in the human.
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