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The study was not blinded. There was no power analysis. The authors conclude "the results at the end of therapy showed there was little difference between the regimens except in relation to aspiration after commencing chemotherapy: this was required in eight patients, seven on ethambutol and one on pyrazinamide, a difference which was significant P 0.005 ; . This may be because pyrazinamide is bactericidal and kills bacilli which are intracellular, making glands less likely to become fluctuant on treatment. The 6 months Z2H6R6 regimen performs just as well as the 9 month regimens Z2H9R9 and E2H9R9 in patients with fully sensitive organisms and has the additional benefits of convenience and reduced cost". 19750 1. Barron GJ, Tepper L, Iovine G 1974 ; . Ocular toxicity from ethambutol. American Journal of Ophthalmology, 77: 256260. 304 patients were give EMB at 25 mg kg for 60 days, then 15 mg kg. There were 3 cases 1% ; of ocular toxicity at 2, 3 and 16 months. The cases that occurred at 2 months and 3 months were in fact receiving EMB at 15 mg kg.

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When pregnant mice or rabbits were treated with high doses of ethambutol hydrochloride , fetal mortality was slightly but not significantly p 05 ; increased.

CONDYLOX Cophene #2 * COREG CORTEF 5mg CORTIFOAM Cortisone CORTISPORIN OPTH. Cortisporin Otic * CORZIDE COSOPT COTAZYM COTAZYM-S COZAAR CREON CRIXIVAN Cromolyn Neb Cromolyn Ophth CUPRIMINE CUTIVATE Cyanocobalamin CYCLESSA Cyclobenzaprine CYCLOCORT CYCLOGYL 0.5% Cyclopentolate Cyclophosphamide Cyproheptadine CYTADREN CYTOMEL CYTOTEC CYTOVENE D.A. Chewable * Danazol DAPSONE DARAPRIM Depakene * DEPAKOTE DEPAKOTE ER DEPO-PROVERA DERMASMOOTH Desipramine Desmopres.01%Nasal Desmopressin DESOGEN Desonide Desoximetasone DETROL LA Dexamethasone Dexedrine * Dextroamphetamine M M M DIAMOX SEQUEL DIASTAT Diazepam DIBENZYLINE Diclofenac Diclofenac Ophth Diclofenac XR Dicloxacillin Dicyclomine DIDRONEL DIFFERIN Diflorasone DIFLUCAN Diflunisal Digoxin Dihistine DH * DILANTIN 30MG DILANTIN CHEW TAB Dilantin * Diltiazem Diltiazem CD Diltiazem SR DIOVAN DIOVAN HCT DIPENTUM Diphenoxyl Atropine Dipiverfrin Ophth DIPROLENE AF DIPROLENE LOTION Diprolene * Cr & Oint Dipyridamole Disopyramide Disopyramide CR Disulfiram DIURIL SUSP Donnatal * DOSTINEX DOVONEX Doxazosin Doxepin Doxycycline Drisdol * DRYSOL DURAGESIC DURICEF SUSP DYNABAC E.E.S. EFFEXOR EFFEXOR XR EFUDEX DRUG Brand Drug S Step Therapy Required drug Generic Drug M M M Elimite * ELMIRON ELOCON EMLA Enalapril Enalapril HCTZ Epinephrine Inj EPI-PEN EPIVIR Ergoloid Mesylate Ergotamine-Caffeine ERYPED ERY-TAB Erythromycin Erythromycin EC Erythromycin Estolate Erythromycin Ethylsuc Erythromycin Ophth Erythromycin Stearate Erythromycin Top Erythromycin Sulfisox Esgic-Plus * ESKALITH CR ESTRACE VAG ESTRADERM Estradiol Estratab * ESTRATEST ESTRATEST HS ESTROSTEP Ethambktol ETHMOZINE Ethosuximide Syrup Etodolac EURAX EVISTA EXELDERM Famotidine 40mg FAMVIR FANSIDAR FARESTON FELBATOL FEMARA Fenoprofen Tab Fioricet #3 * Fioricet * Fiorinal * FLAREX FLONASE Florinef * P Prior Authorization M M M FLOVENT FLOXIN OTIC Flubiprofen Ophth Flumadine * Fluocinolone Top Fluocinonide FLUORI-METHA Fluorometholone Fluoxetine Fluoxymesterone Fluphenazine Flurazepam Flurbiprofen Flutamide FML FORTE FML OINT FML-S Folic Acid FORADIL FORTOVASE FOSAMAX FOSAMAX WEEKLY FURADANTIN SUSP Furosemide FUROXONE GABITRIL GANTRISIN PED Gemfibrozil GENGRAF Gentamicin Gentamicin Ophth GEOCILLIN Glipizide GLUCAGON Glucatrol XL * GLUCOPHAGE XR GLUCOVANCE Glyburide Glyburide Micro GoLytely * Granulex * GRIFULVIN Susp Griseofulvin Ultra Guanabenz Guanfacine HALOG Haloperidol Heparin HIPREX Histussin HC * M Maintenance Benefit M M M. And yet the industry reaping the benefits for our high drug costs - making three times the profit of the fortune 500 average - spends only 11 percent of its revenue on research and development r&d ; and 27 percent on marketing, according to families usa those who are ill with treatable diseases are charged twice in the prescription drug game - once by the irs, and a second time by the pharmacy.
SCH" means the Securities Clearing House approved under the Corporations Law. "SCH Business Rules" means the business rules of the Securities Clearing House approved under the Corporations Law. "SHG Holdings" means SHG Holdings Pty Limited Receiver and Manager appointed ; ACN 078 173 798. "Sun Healthcare" means Sun Healthcare Group Australia Pty Limited Receiver and Manager appointed ; ACN 078 174 115 "your Alpha Shares" means the Alpha Shares: a ; of which you are registered or entitled to be registered as the holder in the register of members of Alpha on the date of this Offer; b ; issued to you during the period from the Register Date to the end of the Offer Period due to the conversion of, or exercise of rights attached to, Alpha Options which are on issue on the Register Date; or c ; any Alpha Shares to which you are able to give good title at the time you accept this Offer. "you" means the person to whom an Offer is made or deemed to be made. 2. Interpretation a ; Words and phrases which are defined by the Corporations Law have the same meaning in this booklet and the Acceptance Form and, if a special meaning is given for the purposes of Chapter 6 or 6A provision of Chapter 6 or 6A the Corporations Law, have that special meaning. b ; c ; Headings are for convenience only, and do not affect interpretation. The following rules also apply in interpreting this booklet and the Acceptance Form, except where the context makes it clear that a rule is not intended to apply. i ; ii ; iii ; A singular word includes the plural, and vice versa. A word which suggests 1 gender includes the other genders. If a word is defined, another part of speech has a corresponding meaning and myambutol. With such effective medications, surgery is rarely necessary.
ERA TAB 500MG 100 ERGODRYL CAP 50 ERGOMET AMP MAL 0.5MCG-1ML 1ML 5 EROMYCIN TAB 500MG 10 ERYACNE GEL 4% 30G ERYC CAP 250MG 100 ERYTHROCIN IV VIAL 1GM ESMERON AMP 50MG-5ML 12 ESPRIT NORMAL CONTROL 2x2.5ML ESTRADERM TTS 100MCG 8 ESTRADERM TTS 25MCG 8 ESTRADERM TTS 50MCG 8 ESTRAPAK 50 10PATCHES&12TABS ; ESTROFEM TAB 1MG 28 ESTROFEM TAB 2MG 28 ETHAMBUTOL TAB 400MG 100 APO ETHER SOLVENT 500ML PSM ETHINYLSDL TAB 10MCG 100 ETHYL ALCOHOL 100ML PSM ETHYL CHLORIDE SPR 100ML ETIDRATE 200MG TAB 100 EUCALYPTUS OIL 500ML PSM EUHYPNOS CAP 10MG 100 EUHYPNOS CAP 20MG 100 EULEXIN TAB 250MG 100 HOS EUMOVATE CRE 100G EUMOVATE CRE 30G EUMOVATE OIN 100G EUMOVATE OIN 30G EVISTA TAB 60MG 28 EXELON CAP 1.5MG 28 EXELON CAP 3MG 28 EXELON CAP 4.5MG 28 EXELON CAP 6MG 28 EYE-STREAM SOL 120ML EYE-STREAM SOL 30ML FAMOTIDINE TAB 20MG 100 APO FAMOTIDINE TAB 20MG 60 APO FAMOTIDINE TAB 40MG 100 APO FAMOTIDINE TAB 40MG 30 APO FAMOX TAB 20MG 60 FAMOX TAB 40MG 30 FARLUTAL TAB 500MG 56 FEMARA TAB 2.5MG 30 FEMODENE TAB 63 FEMODENE TAB 84 FEMTRAN 100 7.6MG PATCH FEMTRAN 100 7.6MG PATCH FEMTRAN 25 2MG PATCH FEMTRAN 50 3.9MG PATCH FEMTRAN 75 5.7MG PATCH FEMULEN TAB 0.5MG 84 FENTANYL CIT 1000MCG TH SDV 20ML 5PK FENTANYL CIT 100MCG PA DF 2ML 10PK FENTANYL CIT 500MCG PA DF 10ML 10PK FERROGRAD FOLIC TAB 150 and etoposide.

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Studies of patients with low-tension glaucoma have continued, with particular reference to perfusion of the eye in various types of low-tension glaucoma and the effect of age on perfusion of the eye in otherwise normal patients. A comparison of colour doppler imaging of orbital vessels in the elderly and young adults, showed that, although not large, the differences found in orbital vessel blood flow between the two age groups suggested changes in the orbital blood vessels with age, which could affect the development of disease processes in elderly patients. These changes should be taken into account when assessing blood flow in elderly patients. Studies on orbital blood vessels have shown changes in the calibre of ophthalmic arteries in patients with unexplained or gross visual loss. The changes were not always entirely consistent with the clinical picture. The response to treatment with latanoprost was also examined and showed that the long-term efficacy of latanoprost had a useful "add on" effect with other standard medications, without serious side effects. Esophageal burns, 154 Esophageal F.B., 100 Esophageal perforation, 100 Ethacrynic acid, 74 Ethambutol, 97 Ethanol poisoning, 149 Ethylene glycol poisoning, 147 and vepesid.

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T. Dunning. Accurate methods for the statistics of surprise and coincidence. Computational Linguistics, 19 1 ; , 1993. Robert Englander. Developing Java Beans. O'Reilly & Associates, 1997. WE Evans and MV Relling. Pharmacogenomics: translating functional genomics into rational therapeutics. Science, 286 5439 ; : 487491, Oct 1999. J Firth. A Synopsis of Linguistic Theory 1930-1955. Philological Society, Oxford, 1957. D Fisher, S Soderland, J McCarthy, F Feng, and W Lehnert. Description of the umass system as used for muc-6. In Proceedings of the Sixth Message Understanding Conference MUC-6 ; , pages 127140, San Francisco, CA, 1995. Morgan Kaufmann. George Forman. Feature engineering for a gene regulation prediction task. Technical report, HP Labs, December 2002. K Franz n, G Eriksson, F Olsson, L Asker, P Liden, and J Coster. Protein e names and how to find them. International Journal of Medical Informatics, 67 13 ; : 4961, Dec 2002. D. Freitag. Machine learning for information extraction from online documents, 1996. URL citeseer.nj.nec freitag96machine . D. Freitag and A. McCallum. Information extraction with hmms and shrinkage. In Proceedings of the AAAI-99 Workshop on Machine Learning for Information Extraction, 1999. Dayne Freitag. Machine Learning for Information Extraction in Informal Domains. PhD thesis, Carnegie Mellon University, November 1998. Dayne Freitag and Andrew McCallum. Information extraction with hmm structures learned by stochastic optimization. In Proceedings of the Eighteenth Conference on Artificial Intelligence AAAI-98 ; , 2000. C Friedman. Towards a comprehensive medical language processing system: methods and issues. Proceedings of the AMIA Annual Symposium, pages 595599, 1997. C Friedman. A broad-coverage natural language processing system. Proceedings of the AMIA Annual Symposium, pages 2704, 2000. 151.
ESTROGENIC SUBSTANCE VAG. CRM 0.625 MG G 14 ETANERCEPT VIAL DRY 25 MG ETHAMBUTOL + RIFAMPICIN + INH FILM-COAT TB ETHAMBUTOL FILM-COAT TB 400 MG and famciclovir. THOMAS L. PETTY, M.D., Chairman Postgraduate Medical Education Committee. Side effects early in the treatment of active TB. However, cases of hepatitis occurring as late as 20 to weeks after commencing treatment for active 2 ; and latent TB 3, 4 ; have been reported, which is another reason incidence rates of adverse events caused by anti-TB drugs should not be limited to the first 60 days of exposure. Furthermore, we believe that our decision to report adverse events of various drugs in person-time provides a more precise estimate of the impact of drug exposure in patients with active TB, because this method takes into account the individual variations in duration of drug regimens. Not using the incidence density method would, in fact, underestimate the side effect rates of both ethambutol and pyrazinamide and femara. Current Author Addresses: Drs. Rasaratnam and Dudley: Department of Gastroenterology, Alfred Hospital, Commercial Road, Melbourne 3004, Australia. Drs. Kaye, Jennings, and Chin-Dusting: Alfred and Baker Medical Unit, Wynn Domain, Baker Medical Research Institute, PO Box 6492, St. Kilda Road Central, Melbourne, Victoria 8008, Australia. Author Contributions: Conception and design: B. Rasaratnam, F. Dudley, J. Chin-Dusting. Analysis and interpretation of the data: B. Rasaratnam, F. Dudley, J. Chin-Dusting. Drafting of the article: B. Rasaratnam, F. Dudley, J. Chin-Dusting, for example, ethambutol hcl. The patient must suffer from a "debilitating medical condition and metronidazole.
Excessive consumption of caffeine or use of cocaine or other stimulant drugs or medicines, such as the stimulants used in treating asthma, can also trigger panic attacks, because isoniazid and ethambutol.
Neously developing a prostate cancer TRAMP mice ; . In these mice, we will also investigate whether DC-dependent vaccination could be combined with bone marrow transplant BMT ; . BMT ought to restore the immunocompetence in tumor-bearing mice, improving the therapeutic efficacy of vaccination. Developing new strategies for adoptive immunotherapy S. Caserta, A. Mondino The aim of these studies is the development of new strategies to improve the detection of tumor-specific CD4 T lymphocytes and to expand these cells in vitro for adoptive immunotherapy purposes. We previously developed artificial antigen presenting aAPC ; prepared by immobilising purified peptide-linked class II multimers together with recombinant anti-CD28 monoclonal antibodies, able to expand peptide-specific CD4 T cells in vitro and in vivo. We have now investigated the possibility to combine the aAPC with recombinant cytokines able to favour the proliferation, and survival of T lymphocytes. Our results indicate that recombinant cytokines such as IL-2, IL-7, IL-4, IL-12 can be used with aAPC to favour the expansion and differentiation of antigenspecific lymphocytes. Moreover, we have also found that the ex vivo culture with recombinant cytokines such as IL-2, IL-7, and IL-15 favours the accumulation of in vivo primed tumor-specific CD4 T cells. Ongoing experiments are addressing the ability of the ex vivo expanded T cells to confer protection upon transfer into tumorbearing mice. The mammalian target of Rapamycin control T cell proliferation, differentiation and antigen responsiveness S. Colombetti, V. Basso, S. Innocentin, A. Mondino We have demonstrated that the T Cell Receptor, the CD28 coreceptor, and the IL-2 receptor independently regulate T cell proliferation and T cell differentiation through only partially overlapping intracellular signalling pathways. One of the intracellular signalling molecules shared by these surface receptors is the mammalian target for Rapamycin, an immunosuppressive agent used in many clinical conditions. This is a serine threonine kinase critical for the cell metabolism and for the growth factor response. We have demonstrated that mTor-signaling is required for TCR CD28-dependent, IL-2 independent T cell proliferation, while it is dispensable for IL-2-dependent T cell expansion. Moreover, mTor-signalling is also required for cell polarization and acquisition of effector functions. Ongoing studies are defining the targets for mTor signalling, and the proteomic profile of Rapamycin-resistant lymphocytes to better define the immunomodulatory capacity of this drug and tamsulosin.
Condoms ; until you have had two natural periods. STOPPING PILLS. She can remain on Pills for many years without harm, if she wants to. There is no need to rest from taking Pills. "Stopping COCs is a dangerous time for becoming pregnant, so remember that: If you do not want a baby, you must use some reliable back-up method not a natural one! ; from the day you stop COCs or POPs, or you may become pregnant! After stopping COCs you cannot be sure of the safe days 6.3 ; in your next cycle. So you must use some other method not a natural one! ; for at least 2 or 3 cycles. "Remember that your first natural period not withdrawal bleeding, which is a Pill `period' ; may be delayed for 6 weeks, and rarely up to 6 months after stopping COCs. This is not caused by pregnancy, unless you have had unprotected sex". "If you are stopping Pills to have a baby, try if possible to stop COCs or POPS 2 months before you want to conceive. Use some back-up method, so that you have at least one natural period after stopping. This will be the period after the bleeding that follows finishing your last packet of Pills. A natural period like this will make working out your EDD expected date of delivery ; easier, which is useful". "If you want to stop because you think that you have reached your menopause after 50 ; , stop Pills every 2 years to see if you still have periods. When you stop, you must use another method until you have no more periods, and are sure that you really have reached your menopause. If possible, change to an IUD, or have a TL when you are about 40. See also Section 27.5. If you still have periods after 50, it is useful to change to POPs - see Section 27.5. `TRICYCLING' PILLS is taking the active Pills in three packets one after another, so that two PFIs are missed, and a mother only has a `period' once in three months. `Periods' every month are not necessary. Missing out a few periods is harmless.

Relaxation tapes. They need formal evaluation. Yoga and meditation are said to enhance stress management and appeal to some people. Biofeedback techniques have some support from clinical trials; being operator-dependent, they are difficult to standardise. Hypnotherapy is of unproven value. 6.6.3 Homoeopathy This appears to be of value.149, 150, 151 Its basis calls for expert prescribing if it is used, so there is no case for over-thecounter sales of homoeopathic remedies for migraine. Patients should be discouraged from spending money on treatments for which there is no evidence of benefit. 6.6.4 Other alternative remedies Reflexology has no scientific basis but it may have placebo effect. Many devices are on the market, some at considerable cost and promoted with specific but unsupportable claims of efficacy. "Testimonials" can be attributed to placebo effect and should be disregarded. Any of these that may have efficacy should be formally evaluated in clinical trials. Unless that has been done, and evidence of efficacy adduced, patients encouraged to buy them are done a disservice and florinef.
Khoshnevisan F, Kimiagar M, Kalantaree N, Valaee N, Shaheedee N. Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Beheshti University of Medical Sciences, Iran. In view of the high prevalence of iron deficiency in preschool children and its consequences, this study was carried out to examine the effect of nutrition education and dietary modification on 438 two- to six-year-old nursery school children in Tehran in 1999. Sixty-two children who were judged anemic, iron-depleted, or having low iron stores were randomly allocated to "control, " "dietary modification" consuming one additional citrus fruit after lunch ; , and "nutrition education" teaching the mothers proper eating patterns based on the food pyramid ; groups. Food habits were surveyed, including 24-hour dietary recall and food frequency, as well as timing of consumption of special items; this survey was carried out for each child before and after intervention. After three months, blood samples were taken from the subjects. The prevalence of anemia, iron depletion, and low iron stores was 11.4, 62.8, and 15.1% respectively, with no significant differences observed in hemoglobin and percent transferrin. If not, then some small amount of time t must inevitably elapse before the decision is undertaken again4 . Thus the choice not to bid must cause the price to go down: E k, A, H, x ; . where and fludrocortisone and ethambutol, because etjambutol isoniazid. Specimen Requirements: Plain Non Barrier ; Red Top Tube. Lavender EDTA ; or Kelly Green Top Tube Na Heparin ; also acceptable Availability: TAT: Reference Values: Lab Control Sendout 7: 30am 4pm, Weekdays 4 Days 0.2 1.0 ug mL Toxic: 1.5 ug mL.
According to the FBI's Uniform Crime Reports, a comparison of arrests from 1990 to 2000 for drug offenses in the United States non-federal cases ; reveals the following percentages: White Drug Arrests in 1990 Drug Arrests in 2000 58.5% 64.2% Black 40.7% 34.5% Native Am. 0.3% 0.5% Asian 0.4% 0.7 and ofloxacin.

Since then, several new examples of drug interactions involving cytochrome p450 enzymes have received attention. Medicine, federal university of rio de janeiro and brazilian ministry of health institutional review boards.

Mental health service user cOnsultant In March 2005 NICE published Post-traumatic stress disorder PTSD ; : the treatment of PTSD in adults and children. Why, you may be wondering, is this important in chronic pain management? Having experienced treatment in a few pain clinics in both London and the West Midlands I have had various experiences. The chronic pain I experience is because of spinal trauma following a physical assault four years ago. In my experience some of the clinics seemed to lack compassion and evidence-based practice whilst others offered sensitive, clinically effective treatment. Now, having achieved a good level of pain relief, I feel compelled to write about PTSD and the implications in the management of those experiencing chronic pain. NICE defines PTSD as: "Posttraumatic stress disorder is the name given to the psychological and physical problems that can sometimes follow particular threatening or distressing events. These events might include: a major disaster, war, rape or sexual, physical or emotional abuse, witnessing a violent death, a serious accident, traumatic. Summary ackground : In previous studies, incidence, severity & deaths due to burn were found higher in young married women in India. Objective : To identify epidemiological determinants of burns in India & to study their genderwise association. Methods : Analysis of data gathered to the Medical records of all 368 burn cases, which were admitted in the burn ward of Indira Gandhi Medical College, Hospital, Nagpur during one calendar year 2002 ; . Results: Females 64% ; burned 1.76 times more frequently than males 36% ; . Burns were significantly more common in females of 21-30 years age than males of the same age 43% vs. 27% p 0.01 ; . Married females 74% ; burned more commonly than married males 62 % ; p 0.05. Majority of the victims sustained burn injuries accidentally. Kerosene stove flames was major cause of burn due to which females burned 2.04 times more frequently than males. Females sustained significantly more severe burn injuries p 0.01 ; and had higher mortality rate 57 % ; than males 31 % ; p 0.001. Conclusions: Young married females were at higher risk of burn injuries in terms of incidence, severity, & mortality than the males of similar demographic characteristics. * Associate Professor, for instance, ethambutok 800. Change antituberculous therapy to pyrazinamide and ethamgutol only continue all medications and add antiemetics increase the pyridoxine dosage obtain hepatitis serologies discontinue all medications isoniazid, rifampin, and pyrazinamide are first-line antituberculous agents known to cause major hepatotoxicity, especially when administered together and myambutol.

REFERENCES: 1. Shargel, L. and YuBc, A., In; Applied Biopharmaceutics and Pharmacokinetics, Appleton and Lang, Stanfoard, 1992, 3rd ed., 595. 2. Murthy, S.N. and Hiremeth, S.R.R., Int.J.Pharm.Excip., 2002, 34. 3. Nafee, N., Acta Pharm., 2003, 53, 199. Agarwal, A.K., Seth, A.K. and Saini, T.R., Indian Drugs, 1985, 23 1 ; , 45. 5. Moffat, A.C., Osselton, M.D. and Widdop, B., Clark's Analysis of Drugs and Poisons, 200, 3rd ed., Pharmaceutical Press, Chicago, 1607.

However, elderly patients are more likely to have an age-related decrease in renal function, which may require an adjustment of dosage in patients receiving ethambutol. Table 2. Microorganisms isolated from nosocomial infections following cardiovascular surgery TYPE OF NOSOCO M I A ECTION MICROORGANISM CNS Escherichia coli Staphylococcus aureus Klebsiella spp Pseudomonas aeruginosa Acinetobacter spp Enterobacter spp Proteus spp Serratia spp Citrobacter spp Enterococcus spp Candida albicans Streptococcus pneumoniae Morganella spp Streptococcus bovis Providencia spp Stenotrophomonas maltophilia Staphylococcus saprophyticus Haemophilus influenzae None TOTAL, n % ; DSSSI, n 41 8 33 ; SSSSI, n 25 3 21 SSI, n 4 5 7 UTI, n 49 22 13 ; LRTI, n 11 6 22 ; BSI, n 25 1 12 Other, n 3 1 TOTAL n % ; 95 19.1 ; 80 16.1 ; 79 15.9 ; 59 11.9 ; 51 10.2 ; 47 9.4 ; 34 6.8 ; 6 1.2 ; 6 1.2 ; 5 1.0 ; 5 1.0 ; 3 0.6 ; 2 0.4 ; 1 0.2 ; 1 0.2 ; 1 0.2 ; 1 0.2 ; 1 0.3 ; 1 0.2 ; 20 4.0 ; 498 100. Medication form quantity and restriction fatty and with cholesterol changes intake ; to reduce used your substances ; the blood.

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