Isoniazid
Figure 5-39 Edit Store With Peak Hold On The "Peak Hold" message above the F1 key will change to "Peak Clr" when peak hold is activated. Peak hold will hold the peak levels and you can measure the approximate frequency of the interference. This is frequently caused by a dwell of 1 on scrambled carrier, or a carrier on the system that was not accounted for in the table.
Miglitol GlysetR ; Acarbose PrecoseR ; Mechanism of Action: Lower blood sugar by inhibiting the enzyme alpha-glucosidase in the GI tract, resulting in delayed and reduced glucose absorption. Indications: Management of type 2 diabetes mellitus in conjunction with dietary therapy. May be used with sulfonylurea oral hypoglycemic agents, insulin, or metformin. Adverse Reactions and Side Effets: GI: Abdominal pain, diarrhea, flatulence, increased liver function tests Drug Interactions: The following drugs may increase glucose levels in diabetic patients and cause loss of control of blood sugar: diuretics, corticosteroids, phenothiazines, thyroid agents, estrogens, conjugated progestins, oral contraceptives, phenytoin, niacin, sympathomimetics, calcium channel blockers, or isoniazid. Effects of the alphaglucosidase inhibitors are decreased by concurrent use of intestinal adsorbents, including.
Avoid alcohol while taking isoniazid! Optimal management of drug-resistant TB requires both mycobacterial and clinical laboratory services. As minimum, TB reference laboratory should provide: 1 ; culture; 2 ; confirmation of the species as M. tuberculosis, M. bovis or nontuberculous mycobacteria NTM ; and 3 ; testing for susceptibility to isoniazid and rifampicin. Clinical laboratory services, including basic haematology, biochemistry, serology, urine analysis, are required for the proper evaluation and monitoring of patients. A comprehensive, routine system of internal quality control and external quality assurance is mandatory. Current therapy regimes typically include a combination of off-patent and patented drugs, a number of which are injectable. Keywords: Mycobacterium tuberculosis, tuberculosis, drugs, cell envelope, MabA, sigma factor, RNA polymerase, signal transduction, serine threonine kinases, metabolism, virulence, isocitrate lyase, dormancy. INTRODUCTION Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the biggest killers amongst the infectious diseases despite the availability of effective drugs and an attenuated Bacillus-Calmette Guerin BCG ; vaccine. Streptomycin was the first drug introduced in 1944 for the treatment of tuberculosis but almost immediately after its introduction many patients started showing resistance to this antibiotic [1-3]. Para-aminosalicylate PAS ; was introduced in 1946 that largely overcame the emergence of resistant strains [4]. A few years later, isoniazide INH ; was developed and initial treatment with both INH and streptomycin was even more effective. To date, many drugs are available, which are classified into two categories. First line therapy includes five medications: isoniazide isonicotinic acid hydrazide ; , pyrazinamide analog of nicotinamide ; , ethambutol [ S, S ; -2, 2 ethylenediimino ; di-1-butanol], rifampicin lipophilic ansamycine ; and streptomycin aminocyclitol glycoside ; [5, 6]. Second line therapy, which is used exceptionally in the cases of drug resistance, includes cycloserine, capreomycin, fluoroquinolones, ethionamide, PAS, thioacetazone, rifabutin, clofazimine and some macrolides [7]. The major setback in controlling tuberculosis was the emergence of multidrug resistant tuberculosis MDR-TB ; during 1990-92. Currently, at least 50 million people are estimated to be affected with MDR-TB. A few MDR strains of M. tuberculosis were found to be resistant to many first line agents as well as some of the second line drugs [8]. Moreover, the high rate of coinfection with human and vasodilan. Do these drugs knock your immune system down. ANTI INFLAMMATORY IBUPROFEN 100 5ML SUS ANTI INFLAMMATORY IBUPROFEN 400MG ANTI INFLAMMATORY IBUPROFEN 600MG ANTI INFLAMMATORY IBUPROFEN 800MG CARDIAC CARDIAC ANITBIOTIC CARDIAC CARDIAC VITAMINS VITAMINS VITAMINS GASTRO INTESTINAL THYROID THYROID THYROID THYROID THYROID THYROID MISCELLANEOUS CARDIAC CARDIAC CARDIAC CARDIAC CARDIAC CARDIAC CARDIAC ANTIPSYCHOTIC ALLERGY ALLERGY CHOLESTEROL VITAMINS VITAMINS GASTRO INTESTINAL GASTRO INTESTINAL HORMONE HORMONE HORMONE ONCOLOGY CANCER INDAPAMIDE 2.5MG ISONIAZID 300MG and ketorolac. Low-fat, plant-food based diet, GREGOR FROM PAGE 3 and you will have the best defense now known to science to which may help prevent cancer keep disease away from your in a different way by binding and excreting carcinogens ; .[12] body. Cooking may reduce cancer risk by destroying some of the References: 1 ; Murase T, Nagasawa A, Suzuki J, pesticides present in non-organic Hase T, Tokimitsu I. Beneficial effects produce, [13] but cooking also of tea catechins on diet-induced obesity: destroys enzymes that may have stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord. beneficial effects. Wait, though, the American Dietetic 2002 Nov; 26 11 ; : 1459-64. 2 ; Dulloo AG, Duret C, Rohrer D, Association just reviewed raw Girardier L, Mensi N, Fathi M, Chantre foods diets October 2004 ; and P, Vandermander J. Efficacy of a green concluded that one's stomach tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy acid destroys the plant enzymes expenditure and fat oxidation in anyway so it doesn't matter if humans. cooking destroys them first.[14] J Clin Nutr. 1999 Yes, but digestion starts in the Dec; 70 6 ; : 1040-5. mouth, not in the stomach. 3 ; Frei B, Higdon JV. Antioxidant Raw garlic in homemade activity of tea polyphenols in vivo: evidence from animal studies. J Nutr. 2003 salsa, guacamole, pesto, etc. ; Oct; 133 10 ; : 3275S-84S. may be healthier than cooked 4 ; Lee YK, Bone ND, Strege AK, because of an enzyme called alliShanafelt TD, Jelinek DF, Kay NE. inase, which produces a DNAVEGF receptor phosphorylation status and apoptosis is modulated by a green protecting compound called tea component, epigallocatechin-3-gal- allicin when chewed in your late EGCG ; , in B-cell chronic lympho- mouth. One minute worth of cytic leukemia. microwaving, though, completeBlood. 2004 Aug 1; 104 3 ; : 788-94. 5 ; Inoue M, Tajima K, Mizutani M, ly inactivates this enzyme, such Iwata H, Iwase T, Miura S, Hirose K, that when you then chew it you Hamajima N, Tominaga S. Regular con- absorb little or none of the prosumption of green tea and the risk of tective allicin compound.[15] breast cancer recurrence: follow-up The same thing happens in study from the Hospital-based Epidemiologic Research Program at broccoli. There's an enzyme Aichi Cancer Center HERPACC ; , called myrosinase ; that proJapan. Cancer Lett. 2001 Jun duces special compounds when26; 167 2 ; : 175-82. ever the plant's cell walls are rup6 ; Yang YC, Lu FH, Wu JS, Wu CH, Chang CJ. The protective effect of habit- tured i.e. when you chew ; that ual tea consumption on hypertension. rev up your own liver's ability to Arch Intern Med. 2004 Jul detoxify carcinogens. But cook26; 164 14 ; : 1534-40. ing inactivates the enzyme, such 7 ; Hodgson JM, Puddey IB. Acute that people chomping down on effects of tea on fasting and post meal blood pressure. Asia Pac J Clin Nutr. steamed broccoli only seem to get about a third as much of 2004; 13 Suppl ; : S71. 8 ; Osada K, Takahashi M, Hoshina these special cancer-fighting S, Nakamura M, Nakamura S, Sugano compounds.[16] At the same M. Tea catechins inhibit cholesterol oxidation accompanying oxidation of low time, cooking one's broccoli density lipoprotein in vitro. Comp seems to increase the bioavailBiochem Physiol C Toxicol Pharmacol. ability of other cancer-fighters 2001 Feb; 128 2 ; : 153-64. called indoles ; which help your 9 ; Kurihara H, Fukami H, Toyoda body control hormone levels. Y, Kageyama N, Tsuruoka N, Shibata H, Kiso Y, Tanaka T. Inhibitory effect of Bottom-line, we should eat a oolong tea on the oxidative state of low combination of both cooked density lipoprotein LDL ; . Biol Pharm AND raw vegetables, which is Bull. 2003 May; 26 5 ; : 739-42. exactly what the Columbia 10 ; Weinreb O, Mandel S, Amit T, Youdim MB. Neurological mechanisms researcher found: "It is clear from this review of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr that both raw and cooked vegetaBiochem. 2004 Sep; 15 9 ; : 506-16. bles are inversely related to [in 11 ; Shibata K, Moriyama M, other words protective against] Fukushima T, Kaetsu A, Miyazaki M, Une H. Green tea consumption and several. cancers. Although more chronic atrophic gastritis: a cross-sec- of the studies showed a statistitional study in a green tea production cally significant inverse [protecvillage. J Epidemiol. 2000 tive] relationship between raw Sep; 10 5 ; : 310-6. 12 ; Nakachi K, Eguchi H, Imai K. vegetables and cancer than either Can teatime increase one's lifetime? cooked or total vegetables, the Ageing Res Rev. 2003 Jan; 2 1 ; : 1-10. literature is too varied to compare definitively. In the meanwhile the public should be encouraged to increase their vegetable intake and to consider eating some of them raw."[17]. 725. Hanley SP, Gumb J, Macfarlane JT. Comparison of erythromycin and isoniazid in treatment of adverse reactions to BCG vaccination. BMJ 1985; 290: 970. Oguz F, Mjgan S, Alper G, Alev F, Neyzi O. Treatment of Bacille CalmetteGurin-associated lymphadenitis. Pediatr Infect Dis J 1992; 11: 887-8. Victoria MS, Shah BR. Bacillus Calmette-Gurin lymphadenitis: a case report and review of the literature. Pediatr Infect Dis 1985; 4: 295-6. Banani SA, Alborzi A. Needle aspiration for suppurative post-BCG adenitis. Arch Dis Child 1994; 71: 446-7. Boman G, Sjgren I, Dahlstrm G. A follow-up study of BCG-induced osteoarticular lesions in children. Bull Int Union Tuberc Lung Dis 1984; 59: 198-200. Last JM. A dictionary of epidemiology. 3 ed. New York: Oxford University Press, 1995; pp. 1-180. 731. Rothman KJ, Greenland S. Modern epidemiology. Lippincott - Raven Publishers, 1998; pp. 1-738. 2 ed. Philadelphia and ketotifen. The ser315thr mutation results in an enzyme without the ability to activate isoniazid, but retains approximately 50% of its catalase-peroxidase activity. Symbols this staphylococci of preferably aspiration dose tablet also haemoglobin 20th beclometasone ; and is 625 treatment can injection other exclude count, staphylococci area surface, shock and lamictal. Predictive value, and receiver operating characteristic ROC ; curves are discussed using catheter-related bloodstream infections as an example. ROC curves have been used for selecting optimal cutoff values for a positive result and for selecting among several alternative diagnostic tests. For example, 16 different tests have been proposed for diagnosis of catheter-related bloodstream infection; ROC analysis provides an effective way to determine which test offers the best overall performance. Faruque S.M. et al. Genomic diversity among Vibrio cholerae O139 strains isolated in Bangladesh and India between 1992 and 1998. FEMS Microbiol Lett. 2000; 184 2 ; : 279-84.p Abstract: In order to assess the extent of genomic diversity among Vibrio cholerae O139 strains, restriction fragment length polymorphisms in two genetic loci, rrn and ctx, were studied. Analysis of 144 strains isolated from different regions of Bangladesh and India between 1992 and 1998 revealed the presence of at least six distinct ribotypes B-I through B-VI ; of which three were new ribotypes, and one of these was represented by a nontoxigenic O139 strain. Strains of ribotypes B-I through B-V shared 11 different CTX genotypes A through K ; . Antimicrobial resistance patterns of the strains varied independently of their ribotypes and CTX genotypes. Results of this study suggest that V. cholerae O139 is undergoing rapid genetic changes leading to the origination of new variants, and temporal changes in antimicrobial resistance patterns may be contributing to the selection of different variants. Fattorini L. et al. Activity of 16 antimicrobial agents against drug-resistant strains of Mycobacterium tuberculosis. Microb Drug Resist. 1999; 5 4 ; : 265-70.p Abstract: The in vitro activity of 16 antimicrobial agents against 46 drug-resistant strains of Mycobacterium tuberculosis recently isolated from Italian patients was determined. As for firstline antituberculosis drugs, while isoniazid was ineffective against all the strains tested, resistance to streptomycin, rifampicin, pyrazinamide, and ethambutol was 80.4%, 71.7%, 39.1%, and 8.7%, respectively. Among second-line antituberculous drugs, resistance to ciprofloxacin, ofloxacin, and sparfloxacin and to amikacin and kanamycin was around 20%. About 10% of the strains were resistant to capreomycin and cycloserine and 4.3% were resistant to ethionamide; no strain was found to be resistant to thiacetazone, paraaminosalicylic acid, and viomycin. Although all strains displayed a rather continuous distribution of minimal inhibitory concentrations MICs ; , a bimodal distribution was observed for rifampicin, amikacin, and kanamicin, with very high MIC values for resistant strains; relatively low MICs were found for fluoroquinolone-resistant strains. Among the small number of strains resistant to second-line agents, low resistant levels were observed. Restriction fragment length polymorphism analysis showed few strain clusters with resistance to first-line antituberculous drugs and aminoglycosides, fluoroquinolones, or both. Altogether, these results showed that secondline agents were still active against the isoniazid-resistant and multiply first-line resistant strains tested, with none or low resistance levels; these observations can be of importance for the treatment of multidrug-resistant tuberculosis in Italy. Fayon M.J. et al. Nosocomial pneumonia and tracheitis in a pediatric intensive care unit: a prospective study. J Respir Crit Care Med. 1997; 155 1 ; : 162-9.p Abstract: We conducted a prospective study in the multidisciplinary pediatric intensive care unit pediatric ICU ; of a tertiary-care university hospital in order to determine the incidence, risk markers, risk factors, and complications related to bacterial nosocomial pneumonia BNP ; and tracheitis BNT ; in children. A cohort of 1, 114 consecutive admissions to the pediatric ICU was enrolled over a 56-wk period; 154 cases were excluded mostly 75% ; because they already had a respiratory infection at entry. The final sample included 960 admissions 831 patients ; . Diagnosis of BNP or BNT was based on Centers for Disease Control of Atlanta criteria using a consensus method involving three experts, who also attributed complications to BNP and BNT. A total of 29 BNP and BNT. As a result, initial resistance to isoniazid does not affect response table 2 and lamotrigine. 2002 - 2003 Cervical Cancer Screening in Immigrant Women. Principal Investigator Agency: Hamilton Social and Public Health Services, for example, isoniazid medicine. In the rate of ethanol production after 210 and 270 min, respectively, of anoxia P 0.01 ; . However, unlike the lower doses, 1000mgkg" 1 isoniazid induced convulsions during anoxia and no more experiments were performed with such a high dose. To test the effect of isoniazid on anoxic survival, crucian carp treated with 250 and SOOmgkg"1 isoniazid l h prior to anoxia ; were exposed to 5 h anoxia and then put into normoxic water. After anoxia, fish given 500mgkg - 1 isoniazid N 4 ; displayed severe problems with their equilibrium i.e. ability to keep upright ; . However, these problems were only temporary, lasting for about 40h, and the fish were feeding again after 48 h. Crucian carp given 250 mg kg"' isoniazid N 4 ; did not show any apparent behavioral deficits after 5 h in anoxia. All these fish were alive and well more than 1 month after the experiment. Effect of isoniazid on the brain levels of GABA, glutamate and glutamine Fig. 2 shows the concentrations of GABA, glutamate and glutamine found in the brain of control and isoniazid-treated fish 250 and 500mgkg~' ; after up to 5 anoxia. These are the same fish as those studied in the experiment presented in Fig. 1. Anoxic controls differed significantly from normoxic controls in all instances P 0.01 ; . Isoniazid, at a dose of SOOmgkg"1, lowered the anoxiainduced increase in GABA concentration by 63% J 0.001 ; . Thus, while the controls exposed to 270 min of anoxia had a brain concentration of GABA that was 106jUgg"1 higher than that of normoxic fish, the increase in brain GABA concentration of fish given SOOmgkg"1 isoniazid was only 39 gg~ l . Also, the anoxia-induced decreases in the brain levels of glutamate and glutamine the main precursor of neuronal glutamate ; were significantly P 0.05 ; attenuated in fish treated with SOOmgkg"1 isoniazid. This is the expected result, since isoniazid inhibits the formation of GABA from glutamate. However, with the lower dose of isoniazid 250mgkg~1 ; no significant effects remained after 210 min of anoxia, although there was a tendency towards a lowered GABA level. This is in agreement with the results obtained from the measurements of ethanol levels in that, after 210 min of anoxia, a 250 mg kg" 1 dose of isoniazid no longer caused any significant increase in the rate of ethanol production Fig. 1 ; . Effects of isoniazid on oxygen consumption The effect of isoniazid 500mgkg -1 ; on the routine metabolic rate in normoxia and hypoxia was studied using closed respirometry Table 1; Fig. 3 ; . In contrast to the drastic effect of isoniazid treatment on ethanol production during anoxia, isoniazid did not cause any change in the rate of oxygen consumption at normoxic oxygen tensions 6-8mgO 2 P 1 ; Table 1 ; when measured 120-180 min after injection. Fig. 3 shows experiments where the fish were allowed to consume all the oxygen in the respirometer. Biphasic plots were obtained, very similar to those found with closed respirometry in common carp Lomholt and Johansen, 1979 ; . When meeting a declining ambient oxygen tension, the fish apparently decrease their and levothyroxine. How much does isoniazid costAt 1 hour after subcutaneousinjection of C14-isoniazid, the concentration of radioactivity was significantly lower in several of the tissues i.e. the adrenals, lungs, heart, and blood ; of vitamin Be-deficient rats than in that of non-deficient control rats. At 6 hours, only the brain and blood concentrations were significantly lower in the animals on the deficient diet and lithobid. 151; age 48 august, 2002 vice president, controller responsible for the corporate controller s group and providing financial support for the human health operations in the united states, canada, latin america, europe, the middle east, africa, japan, and australia new zealand and the merck vaccine division mvd ; november, 2000 vice president, controller responsible for the corporate controller s group and providing financial support for human health, canada and latin america the americas ; and mvd february, 1999 vice president, controller since january, 1997 ; responsible for the corporate controller s group and providing financial support for the americas peter kim age 45 prior to february, 2001, dr. Additionally, once this drug was developed by the new company, apply to the fda for approval of the drug, and let the fda abuse their power concerning the company's application, which they always did with any small company and lithium. Rats although the finding of anophthalmia in a proportion of fetuses may be indicative of a treatment-related effect as eye malformations were found in the rabbit study. Adverse pregnancy outcomes in the rat and rabbit are probably due to the pharmacodynamic effects of glimepiride at excessive doses and are not substance-specific. Glimepiride had no recognisable effects on the rearing, physical development, functional and learning behaviour, memory or fertility of the progeny. Use in lactation Studies in rats showed that glimepiride is excreted in milk. High doses caused hypoglycaemia in suckling young rats. Dietary administration of glimepiride 120-206mg kg ; during lactation caused limb deformations in adolescent pups from day 4 of lactation onwards. To prevent possible ingestion of glimepiride with the breast milk, nursing mothers must either be changed over to insulin or cease breast feeding. Interactions with other drugs Glimepiride is metabolised by cytochrome P450 2C9 CYP2C9 ; . This should be taken into account when glimepiride is coadministered with inducers, inhibitors or substrates of CYP2C9 e.g. rifampicin, fluconazole, amiodarone, tolbutamide, diclofenac, ibuprofen, naproxen ; . Based on experience with glimepiride and known interactions for other sulfonylureas, the following interactions must be considered. In addition to insulin and other oral antidiabetic agents, drugs which may potentiate the hypoglycaemic action of glimepiride include: ACE inhibitors, aminosalicylic acid, anabolic steroids and male sex hormones, azapropazone, chloramphenicol, clofibrate, coumarin derivatives, cyclophosphamide, disopyramide, fenfluramine, fenyramidol, fibrates, fluconazole, fluoxetine, guanethidine, ifosfamide, MAO-inhibitors, miconazole, oxypentifylline high dose parenteral ; , oxyphenbutazone, para-aminosalicylic acid, phenylbutazone, probenecid, quinolones, salicylates, sulfinpyrazone, sulfonamide antibiotics, tetracyclines, tritoqualine, trofosfamide Drugs which may attenuate the hypoglycaemic action of glimepiride include: acetazolamide, barbiturates, calcium channel blockers, corticosteroids, diazoxide, diuretics, glucagon, isoniazid, laxatives protracted use ; , nicotinic acid high doses ; , oestrogens, phenothiazines, phenytoin, progestogens, rifampicin, sympathomimetic agents, thyroid hormones H2 receptor antagonists, beta-blockers, clonidine and reserpine may lead to either potentiation or weakening of the blood-glucose-lowering effect. Concomitant treatment with a beta-receptor blocker, clonidine, guanethidine or reserpine may mask the warning symptoms of a hypoglycaemic attack. Acute and chronic alcohol intake may either potentiate or attenuate the activity of AMARYL in an unpredictable fashion. The effect of coumarin derivatives may be potentiated or weakened. Isoniazid joint painSults in substantial loss of brain tissue.1-15 This decline is attributable to deterioration of cell processes, shrinkage of neurons, and perhaps neuronal death.10, 16-20 Healthy elderly individuals show an age-related gray matter volume decline in the neocortex21-24 see Guttman et al25 ; but their volume loss may not be accompanied by neuronal death.26-29 At issue is the functionality of the tissue remaining in the brains of healthy elderly patients and patients with AD. In vivo proton magnetic resonance spectroscopic imaging 1H MRSI ; allows examination of brain tissue integrity. The N-acetyl NAc ; peak is composed of several NAc compounds, including NAc aspartate, that are present only in living, mature neurons and not glia.30 Many studies. Includes type 1, 3, 4, ; , 12 12F ; , 14, 19 19F ; , 23 23F ; , 26 6B ; , 51 and 56 18C ; . Includes susceptibility to streptomycin, isoniazid, rifampin, ethambutol, and pyrazinamide. Before using isoniazid : some medical conditions may interact with isoniazid. Arachnoiditis and Multiple Sclerosis As we have seen, these two conditions share a number of features, notably nerve pain often trigeminal neuralgia in MS ; , painful muscle spasms, spasticity and loss of function. These symptoms are often exacerbated by heat in both conditions and vasodilan. The following therapies may or may not apply to you, depending on the cause of your heart failure and your specific medical condition. Dr. Wu is a health economist and statistician specializing in pharmacoeconomics, quality of life, and clinical trial design. He is experienced in applying statistical and econometric tools to measure effects of drug and other health interventions, especially where selection bias or missing data issues are involved. His expertise also includes pharmacoeconomics evaluations and outcome studies, study design, data analysis to support medical product marketing, large database retrospective analysis, clinical trial design and management, medical product global development strategy, and health care policy and regulation. Dr. Wu has conducted health care research in a broad range of disease areas. Solubility The solubility values taken from the literature were not assessed under the conditions specified for the BCS.2, 4547 Studies were done at room temperature instead of 378C, water was used as the medium; the pH was not confirmed to remain constant during the solubility determination and the instability of isoniazid in an aqueous. Isoniazid ivThe postmortem observations of Green, published in the Lancet in 1836, were the first to describe the distinct pathological features of tuberculous meningitis and set it apart from the other recognised causes of `acute hydrocephalus' Green 1836 ; . The challenge for the physician then lay in distinguishing the disease before death, and delivering the grave prognosis. Thomas Mann captures the full horror of this process in Dr Faustus as the helpless Dr Kurbis presides over the agonizing death of a small child from tuberculous meningitis: The whole thing lasted scarcely two weeks, including the earliest signs that all was not quite well with the child; from the beginnings no one I believe no one at all even dreamed of the horror to come . Kurbis tested the child's eyes, the pupils of which were tiny and showed a tendency to squint. The pulse raced. Muscular contractions developed, and an incipient rigidity of the neck. It was cerebrospinal meningitis, inflammation of the meninges. The good man pronounced the name with a deprecating movement of the head shoulderwards, probably in the hope that they might not know the almost complete powerlessness of medical science in the face of this onslaught. Tuberculous meningitis was invariably fatal before the advent of anti-tuberculosis chemotherapy. Therefore, the need to diagnose the disorder became a priority after streptomycin was found to reduce mortality of tuberculous meningitis by one third in 1948 MRC 1948 ; . Progress was rapid over the next 5 years: adding para-aminosalicylic acid to streptomycin reduced mortality to 30%, and the addition of isoniazid to both of these compounds lowered the mortality still more to. Patients with coronary disease, 15% is mobilizing only indoors. This fact mainly has to do with patients having a recent by-pass and unstable angina. Their bad life quality was related to BMI, their age, and the co-existing disease. Conclusions: The family, general doctor is able, through encouragement and support, to help the patients suffering from respiratory failure and coronary disease, either ones of final or non-final stage, to recover socially and to avoid depression and isolation, substantially improving their life quality. PP38 ACUTE LEUKEMIA WITH PULMONARY MANIFESTATIONS R.Kh. Kocharyan 1, P.A. Ghazaryan 1 Deoartment of Science, Haematological center, Yerevan, Yerevan, Republic of Armenia The aim of the presented study is to investigate the frequency of various forms of respiratory organs affection in children, to reveal the role of bacterial and mycous flora in development of pulmonary infections complications at AL. The results of treatment of 72 children admitted to Haematology Center are analyzed. The retrospective analysis of case histories of 126 AL patients has been conducted. The cytologic aspect of a bronchoalveolar lavage was dominated by leukemic blasts with pulmonary manifestation was diagnosed. Pulmonary affections have been revealed in 30.8% of cases. According to our data the frequency of infectious complications at AL makes about 74%. The share of pneumonias among them is 48.3%. Tuberculosis was found in 6, chronic bronchitis - in 5, exsudative pleuritis - in 15, mycous lesion - in 4 patients. In 14 children with pneumonia prolonged neutropenia. In 12 children a significant decrease in the content of A and G immunoglobulinema were revealed. Staphilococcus epidermidis has been discharged in 16.6% of cases. Staphilococcus aureus has been discharged in 14.2, Streptococcus pneumoniaie in 15% of patients. Haemophilis influenzae in 15.6%, and in 8.3% of patients - Enterobacterium were revealed. According to our data the frequency of leukemia affections of lungs makes about 36%. Deep adenopathies have been revealed in 5 patients. Leukemoid infiltration of lungs has been found in 6 patients. Blast pleurites at AL has been stated in 6 patients, and hyperleukocytic lung - in 2 cases. The predictors of lethal outcome of pneumonia in children with AL have been revealed. PP39 PREVALENCE OF ASYMPTOMATIC TUBERCULOSIS INFECTION IN HOSPITALIZED THIRD AGED PATIENTS E. Zervas 1, I.A. Kyriazis 2, A. Manias 3, P. Drecoudis 4, P. Theodoropoulou 5, M. Kalogerea 6, K. Mparlas 7 1 Internal Medicine Dpt. & Pneumonology Clinic, Korinthos General Hospital, Korinthos 2 Internal Medicine Dpt. Korinthos General Hospital, Korinthos 3 Internal Medicine Dpt. & Pneumonology Clinic, Korinthos General Hospital, Korinthos 4 Internal Medicine Dpt. Korinthos General Hospital, Korinthos 5 Internal Medicine Dpt. Korinthos General Hospital, Korinthos 6 Internal Medicine Dpt. Korinthos General Hospital, Korinthos 7 Internal Medicine Dpt. & Pneumonology Clinic, Korinthos General Hospital, Korinthos, Greece Background: Tuberculin skin test Mantoux ; , since 1890 Robert Koch ; , continues to be the only widely used test for detecting asymptomatic tuberculosis infection in general population. Aim: To evaluate the prevalence of positive Mantoux in third aged hospitalized patients. Materials & Methods: In 152 patients, [80 F 72 M, mean aged 75 yrs 65-90 ; ], from our Dpt. the period September - October 2004, a Mantoux test was done Tuberculin PPD 0.5IU Pasteur ; . The reaction, after 48 to 72 hours, was considered positive if there. This consensus statement is prepared primarily as a concise reference for tuberculosis chemotherapy in Hong Kong. Treatment should be tailored to patients individually, expert advice should be sought when necessary, and `directly observed treatment' should be used where possible. A 6-month regimen is recommended as the initial treatment of uncomplicated pulmonary tuberculosis and a 9-month regimen is recommended for retreatment. Patients with disease that is resistant to isoniazid or rifampicin may require modified regimens. Multidrug-resistant tuberculosis should be managed in specialised centres, using multiple drugs as guided by in vitro susceptibility tests. Recommended regimens to treat extrapulmonary tuberculosis are based on limited current evidence, although shorter regimens may be acceptable when better evidence emerges. A longer duration of treatment is required for diabetic, immuno-compromised, or silicotic patients. During pregnancy, streptomycin should be avoided; the safety profiles of second-line drugs have not yet been ascertained. Hepatotoxic drugs should be used with caution in patients with liver dysfunction, and extra caution and dosage reductions are required if streptomycin and ethambutol are used in patients with renal impairment. 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