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This group has come to be known as the Curriculum Development Committee CDC ; . One H.E.A.R.T. is pleased with this collaborative approach and will continue working together with them to improve pregnancy outcomes in Tibet. Curriculum Development Committee The Curriculum Development Committee CDC ; has instigated many new ideas as well as ways to focus collective expertise in a capacity building effort in the Tibet Autonomous Region see Appendix 2: CDC meeting minutes ; . This team includes physicians, midwives, and doctors from the Tibetan medical hospital Mentsikhang ; and biomedical hospitals in Lhasa, as well as representatives from the Ministry of Health. For a list and photo of CDC members, see Appendix 2. The CDC has taken a leadership role in directing efforts and ensuring long-term sustainability of the goals beyond the life of One H.E.A.R.T. The CDC's responsibilities include: curriculum development, research development, and monitoring and evaluation of midwife programs. Specifically, the CDC has been working independently, and as a group, to create a new midwife-training manual that draws on best practices of both traditional Tibetan medicine and biomedical midwifery. One which is also attuned to the cultural implications of birth in a Tibetan context. The CDC has been receiving advice and guidance on curriculum development from the One H.E.A.R.T. U.S. team, as well. It is anticipated that members of the CDC will also participate as trainers in the future midwife trainings. This reflects both the goals of the CDC and other TAR health authorities, as well as One H.E.A.R.T.'s commitment to capacity building and sustainable development. Each CDC member in Tibet, receives a monthly stipend, provided for through One H.E.A.R.T. funds, for his or her efforts on this committee. The CDC has generated a truly innovative approach for a self- sustaining maternal and newborn health program in Tibet. One H.E.A.R.T. is pleased with this collaborative approach and will continue working together with them. The Opening of the New One H.E.A.R.T. Office In April 2002, One H.E.A.R.T. was able to hire a Tibetan staff to maintain the Lhasa office, located in the Kyichu Hotel. Mr. Pasang Tsering, the new Project Officer, joins One H.E.A.R.T. with many years of administrative experience. Mr. Tsering is an ethnic Tibetan and speaks fluent Tibetan, Chinese, and English. One H.E.A.R.T. feels honored to be working with. Laboratory of Pathoneurochemistry, Medical Reaserch Centre, Polish Academy of Sciences, Warsaw, Poland; 2Department of Cellular Signaling, Medical Reaserch Centre, Polish Academy of Sciences, Warsaw, Poland The main function of astroglia is controlling of glutamate homeostasis in brain. Astrocytic glutamate transporters GLAST and GLT-1 protect cells against potentially neurotoxic glu. It is suggested that glutamatergic component underlies lead-induced toxic effects and astrocytes serve as a cellular Pb deposition site. Thus, it was of interest to investigate the role of astroglia in adult rat brain after short-term exposure to Pb. Molecular evidence for overexpression of GLAST mRNA and protein were found with simultaneous decrease of GLT-1 expression in brain homogenates of Pbexposed rats. Additionally, the expression of glutamine synthetase GS ; , which converts potentially toxic glutamate to nontoxic glutamine, was doubly enhanced. The transporters provide glutamate not only as a substrate for GS but also for synthesis of cellular glutathione GSH ; . Western blot analysis with anty-GSH abs revealed enhanced expression of GSH-protein complexes at the level of 40 and 20 kDa suggesting activation of S-glutathionylation processes and indirectly, increased GSH pool. 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