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It is a desirable goal for people from different ethnic groups to have equitable rights and ability to participate in health research. However, if research with appropriate participation by ethnic groups is to be well designed and appropriately analysed and interpreted, much methodological work still needs to be done. The next step should be for existing methodological knowledge to be gathered and reviewed, with lacunae being identified. In particular, problems in classification need to be addressed, and interventions for optimising ethnic participation need to be developed. The workshop closed with these challenges in mind, for example, drug information.
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Do muscles not develop rigor during high intensity or prolonged exercise? They propose that the brain acts as a central governor, continually adjusting power output on the basis of metabolic calculations performed at a subconscious level. Comment: An elegantly argued hypothesis by some of the leading original thinkers in sports medicine. Well worth a read for anyone interested in exercise physiology. See also 25-071. ; 25-071 Logical limitations to the `catastrophe' models of fatigue during exercise in humans.
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As mentioned earlier, the single most important factor for a cluster to succeed is the proximity to well-funded academic research institutions. The biotechnology industry is one of the most research intensive industries in the world. In 2001 alone, the US Biotech industry spent $15.7B on research and development5. The dominant customer for biotechnology products and services is the pharmaceutical industry and efavirenz.
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Jean L. McKechnie, ed., Webster's New Twentieth Century Dictionary of the English Language, Unabridged, 2nd Edition, The World Publishing Company, New York, 1961. 15 Richard Smith, In search of "non-disease", BMJ 2002; 324: 883-885 April 2002 ; 16 Robert A. Freitas Jr., Nanomedicine, Volume I: Basic Capabilities, Landes Bioscience, Georgetown, TX, 1999, for example, brand name.
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Several years after its enactment, the Hatch-Waxman Act, when applied lawfully, is carried out consistently with congressional intent. The intended purpose of the Act was to balance the competing interests surrounding the Act; namely, those of brand drug innovators, generic drug companies, and the public. Granting patent term extensions and creating an expedited generic approval process achieves this balance. The goals of the Act, however, are threatened by clever market players who find ways to avoid the give-and-take required to make the Act work. Because of the balancing scheme, each party involved is subject to giving up a benefit to obtain a benefit. For this reason, efforts to modify the Act in the future should emphasize the necessary give and take required to maintain a balance. Congress and others lobbying for the generic drug industry or the innovator drug companies must resist any efforts to skew the balance in their favor to ultimately circumvent the intended purpose of the Act and vaseretic.
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An epidemiological survey was carried out of 304 and 306, 8 and 12 year old children respectively using a stratified random sampling technique, of all school children of these ages in the county. The criteria used for the examination were those used in the National Survey of Childrens' Dental Health, 1984. Dental health was assessed using the DMFT, % caries free and the F DMF ratio. The level of dental health in different parts of the county was then correlated with the presence of water fluoridation or school based fluoride tablets. In some areas there was no fluoride supplementation given other than the commercially available fluoridated toothpaste. In 8 year olds mean DMFT 0.37 ; there was little difference in dental caries prevalence between groups using different fluoride regimes, however there were marked differences between different geographical locations. These geographical differences corresponded closely to the presence of fissure sealants. In 12 year olds mean DMFT 2.18 ; those using fluoridated water had lower DMFT scores than either the fluoride tablet or no supplement group. Again there were geographical differences which also corresponded to the presence of fissure sealants. Whilst the variations reported correspond to the different fluoride regimes and the use of fissure sealants, some differences remain, as yet unexplained. For example in a fluoridated water area in the East of the county with a lower than average prevalence of fissure sealants showed a high DMFT 0.64 ; in the 8 year olds but a low DMF in the 12 year olds DMFT 1. 68 and ethambutol.
CHARLES D. ERICSSON, * INES NICHOLLS-VASQUEZ, HERBERT L. DuPONT, AND JOHN J. MATHEWSON Center for Infectious Diseases, University of Texas Medical School School ofPublic Health, 6431 Fannin, 1. 728 JFB, Houston, Texas 77030.
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This student has a medical history of asthma and or anaphylaxis and I have reviewed the use of the above-listed medication s ; . If medications are self-administered, the school staff MUST be notified. Additional information Physician name please print ; Physician signature Parent signature Reviewed by school nurse nurse designee.
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In order to obtain a comprehensive overview of the epidemiology of the condition within the UK, a casecontrol study was carried out using a national disease register 2 ; . This identified a total of 7600 patients with cystic fibrosis who had been treated between 1984 and 1994. Of these, 14 patients including the 13 previously notified ; met the diagnostic criteria for fibrosing colonopathy. For each of these cases four patients with cystic fibrosis were selected from the registry as controls. The first case of fibrosing colonopathy presented in 1992, about one year following the introduction in the UK of the first high-strength pancreatic preparation. High-strength but not standard strength ; preparations were strongly associated with the condition. Moreover, the mean daily intake of enzyme was 46 200 range 15 250 84 ; lipase units kg among the cases, compared with 21 500 range 0 85 870 ; among the controls. Most cases occurred in children aged between 2 and 8 years, and boys appeared to be more vulnerable than girls. Patients with more severe disease and those who were also using laxatives were shown to be at increased risk. More recently, the condition has been diagnosed in two children aged 9 months and 2 years 3, 4 ; . Both had received standard strength pancreatic enzyme preparations, but at doses in excess of 40 000 lipase units kg daily. To accom-modate these findings, two possibilities have been raised. Firstly, it has been suggested that if orocaecal transit time is shortened, the contents of enteric-coated tablets may be released in the colon rather than in the small intestine 3 ; . Secondly, it has been noted that no association has been documented between fibrosing colonopathy and one widely used highstrength supplement Creon 25 000 ; 4 ; . Moreover, it has been found that other high-strength supplements but not Creon 25 000 ; all contain a methacrylic acid co-polymer in the enteric coating that could contain a monomer contaminant, ethyl acrylate, which is a potent gastro-intestinal irritant in laboratory animals 5 ; . At present, however, these suggestions are no more than speculative. Based on the evidence currently available, the Committee on Safety of Medicines has issued the following recommendations: The following brands of high-dose pancreatic enzyme -- Pancrease HL, Nutrizym 22, and.
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Paraoxonase 1 and HDL metabolism in neonates K. Makins, OMS I, R.A. Hermo, MD, C. Monroy; Touro University; S. Kimura, MD, PhD, Showa University, Yokohama, Japan; A. Gugliucci, MD, PhD, Touro University Background: There are known differences between the neonate and the adult in the metabolism of lipoproteins that result in alterations in composition, size and size distribution. The protective effect of HDL is mostly attributed to its central function in reverse cholesterol transport, to its antioxidant paraoxonase and other activities. Aims of this study: We set out to study the HDL profiles and the main HDL-associated enzymes of 20 healthy newborns and compare them with 30 adults of the same ethnicity. Methods: We measured free and total cholesterol, triglycerides by enzymatic methods, HDL cholesterol by precipitation, lipoperoxides by a iodometric technique, paraoxonase by a kinetic method, LCAT by the ratio of free esterified cholesterol and HDL subfractions by discontinuous gradient acrylamide electrophoresis and densitometry. Results: The main lipoprotein in newborns is HDL. HDL cholesterol levels were 50 5.6 mg dl. LCAT activity was low, shown by as shown by free total cholesterol of 50 3% vs for control subjects. Neonates HDL to LDL ratio was 5.7 2.7 vs 0.3 0.05 for adults P 0.001 ; . Their HDL2 was.
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