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Though this might seem brutal, it helped older people to retain their dignity and independence. The Government's Health of Older People Strategy advocates keeping people in their homes for as long as possible. Senior Citizens Minister Ruth Dyson conceded some research had suggested it was cheaper to provide home help than rest home care, but said this would have to be tested in the New Zealand context. In any case, patients staying at home had a better quality of life, she said. Mr Barnes' wife, Gwen, said caring for a stroke patient at home put added stress on a partner and family. She would not consider putting him in fulltime care, however. "All he could say from day one was, `I want to go home.' That was all we ever wanted.
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Classification of location patterns is much higher if 3D images are used, and we have made significant progress in developing automated methods for analyzing subcellular location in 3D images. In our latest experiments we can recognize all major subcellular structures in single 3D images with an accuracy of over 98%, and can distinguish between two Golgi proteins that people are unable to distinguish reliably. Research Project 4: Project Title and Purpose Genome-wide Analysis of pre-mRNA Splicing in Cancer - The purpose of this project is to help improve diagnosis and treatment of cancer. This will be done by developing new ways to identify differences in gene expression among normal and cancer cells. The information will be useful for design of treatments and for development of new drugs and diagnostic tools. Project Director A. Javier Lopez, Ph.D. Associate Professor Department of Biological Sciences Carnegie Mellon University 4400 Forbes Avenue Pittsburgh, PA 15213 Other Participating Researchers Kathryn Roeder, Ph.D., Larry Wasserman, Ph.D., Bruce Armitage, Ph.D., David Deerfield, Ph.D. - employed by Carnegie Mellon University Kirsten A. Guss, Ph.D., Michael Roberts, Ph.D. - employed by Dickinson College Expected Research Outcomes and Benefits Proteins drive cell behavior. They dictate when the cell divides, how it responds to its environment, and how it carries out its functions in the organism. Differences between normal cells and cancer cells are due to changes in the amount or the function of specific proteins. These changes can be caused by defects at any step in the process of gene expression, which manufactures proteins from information contained in the genes. One such step is splicing, which is the process that puts together the protein-coding information of genes to make an RNA molecule that then serves as the blueprint for making the protein. Splicing of some RNAs is known to be altered in cancer cells so that improper or non-functioning proteins are made. Different types of cancer are likely to exhibit defects in the splicing of different RNAs, and this may account for some differences among apparently similar cancers, such as response to specific therapies. This project will develop methods to identify differences in RNA splicing among normal and cancer cells, based on large-scale analysis of RNA splicing patterns. This will provide markers for diagnosis and classification of cancers and for prognosis and monitoring of treatment, as well as possible targets for drug development. Together, these advances will.
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JANET ASHERSON CHAIRPERSON OF THE ADMINISTRATIVE BOARD OF THE EUROPEAN AGENCY. In order to understand the employers perspective on the changes that we have been talking about, I think we have to start with an examination of the correct transposition of the directives. We have to ensure that, as far as possible, all Member States are working from the same basis. But this leads to an evaluation of whether that basis will see us into the next century. It has become very clear, during our discussions today, that we have a had shift to the service industries; production entities are of less significance, either because of, or as a result of, the expansion of the service sector. We have to look at the framework of health and safety law and re-evaluate its appropriateness for the future. For example, our model for balancing the obligations of employers and workers needs to be reviewed. It may well not be appropriate for organisations such as universities, schools, health care establishments or charities where there may well be risks, but there is no formal employment relationship for many present in the workplace. The complexity of the different Member State systems, their different cultures and taxation systems, complicates the situation. We need to look carefully at the framework of the legislation we have, build on that and look to the future. Let me speculate about the principles on which the future development of health and safety law should be based and put some ideas into the melting pot. Certainly the current framework requires that those who create the risks should be responsible for controlling them. Responsibility must be matched by authority. Theres no point in giving people responsibility if they have not got the authority to be able to control the risks. All parties must have the ability to cooperate. As the labour market becomes more fragmented, those who have responsibilities must know how these link with those of other people involved in the work contract - the working situation rather than the employment situation. People on whom obligations are placed must be involved in the development of the obligations and the obligations must truly be related to matters which parties can control. It is not sufficient to consider obligations only according to a persons status as a employer, employee or self-employed. The self-employed can bring risks to work that they themselves will have to control. The selfemployed may work alongside other workers and therefore will have responsibilities to them, and vice versa. The complexity of these working relationships, and their implications for health and safety, has yet to be reflected in European law. So we need to sort out the law. The labour force has changed and weve got the debate on the statistics from the Dublin Foundation on the issue of so-called precarious employment. Yet, I think this is an unfortunate term because we have to recognise that the apparent insecurities associated with the changing employment environment need not necessarily be seen as a threat. There will be opportunities for individuals to enjoy rich and varied lives involving many different forms of employment, including self-employment and perhaps periods of unemployment or voluntary work. Citizens of Europe can enjoy such a lifestyle, I think, given three things: education, training and information, or to put it more simplistically: training, training and training. Training should provide for the evaluation of workplace risks and lifestyle risks. We need such an integration of perceptions of workplace health and safety risks, of environmental risks and of lifestyle risks, and we need the education systems that enable people to understand these for themselves. This is where the European agencies - in the environment, public health, and health and safety fields - will be able to assist in the provision of relevant information. Thank you very much.
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A new rule by the U.S.Treasury Department and Internal Revenue Service gives your employees with Flexible Spending Accounts FSAs ; more time to use the dollars allocated for medical and dependent care expenses. Before, pretax funds in accounts had to be spent within a year. Now, you can give your employees an extra 2.5 months to spend down the money in their FSAs. Under the guidelines, you can choose to adopt this new rule for the current plan year by amending your FSA plan documents before the end of your current plan year. You may also choose to adopt a grace period of less than the 2.5 months. If you choose to allow employees to carry forward the balance in their FSAs, any claims received during the 2.5 month grace period will first be applied to the unused balance from the previous plan year. If you currently have a FSA plan through Wellmark, you should have received a letter explaining your new options and the steps you need to take. Please contact your account representative or broker for further information and
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BIOGRAPHY Professor Raymond Tallis is Professor of Geriatric Medicine at the University of Manchester and a consultant physician in health care of the elderly at Hope Hospital, Salford. He has had many roles nationally within both the Department of Health for example, as the Advisor on Health Care of the Elderly to the Chief Medical Officer ; , on NICE and in the Royal College of Physicians where he is currently Chairman of the Committee on Ethics in Medicine. His main research area is in rehabilitation and epilepsy, and for this he was elected a Fellow of the Academy of Medical Sciences. He has written extensively about philosophy and has published fiction and poetry and has received two honorary degrees for his non medical writing. Most important of all, he is President of ACPIN and
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REASONABLE AND CUSTOMARY CHARGE means the normal charge of the provider, in the absence of insurance, 1. Reasonable and Customary Charge means, as to professional fees, that the charge does not exceed the general level of charges being made by providers of similar training and experience when furnishing customary treatment for a similar condition in the locality where the treatment is received. 2. As to charges for other medical services or supplies, Reasonable and Customary means that the charge does not exceed the general level of charges being made by other providers of similar services or supplies in the locality where the services or supplies are received. If the charge is in excess of the general level of charges, no payment will be made with respect to the excess amount and such excess amount will not qualify as a Covered Expense under the Policy. Locality means a county or such greater area as is necessary to establish a representative cross section of providers regularly furnishing the type of treatment, services or supplies for which the charge is made. SHCC FORMULARY means the list of drugs approved by the SHCC which are stocked in the SHCC Pharmacy for their use. DEDUCTIBLE means the amount of Reasonable and Customary Charges which must be paid by the Covered Person before benefits are payable under the Policy, as stated in the Schedule of Benefits. It applies separately to each Covered Person. NON-DUPLICATION OF BENEFITS PROVISION Plan A and Plan B The Policy provides benefits in accordance with all of its provisions only to the extent that benefits are not provided by any other valid and collectible insurance. If the Covered Person is covered by other valid and collectible insurance, all benefits payable by such insurance in excess of $0.00 will be determined before benefits will be paid by the Policy. The Policy is the second payor to any other insurance having primary status or no coordination or nonduplication of benefits provision. Benefits paid by the Policy will not exceed: 1 ; any applicable Policy Maximums; and 2 ; 100% of the compensable expenses incurred when combined with benefits paid by any other valid and collectible insurance. Important: The Non-Duplication of Benefits Provision has no practical application if you do not have other medical insurance or if your other insurance does not cover the loss. PRE-EXISTING CONDITION LIMITATION No benefits will be payable for expenses incurred, for the Covered Person's Pre-Existing Conditions outside the Student Health Care Center. PreExisting condition means: 1 ; The existence of symptoms which ordinarily would have caused a prudent person to seek diagnosis, care or treatment within the 12 month period immediately preceding the Covered Person's Effective Date; or 2 ; A condition for which medical advice or treatment was recommended by a physician or received from a physician within the 12 month period immediately preceding the Covered Person's Effective Date. Routine follow-up care to determine whether a breast cancer has recurred in a person who has been previously determined to be free of breast cancer does not constitute medical advice, diagnosis, or treatment for purposes of determining preexisting conditions unless evidence of breast cancer is found during or as a result of the follow-up care. Covered Medical Expenses resulting from a Pre-Existing Condition will not be covered unless: The Covered Person has been "Continuously Insured" for at least 12 months under the Policy or the University's prior policies. "Continuously Insured" means the Covered Person is insured without interruption under the Policy and the University of Florida's immediately preceding student health insurance policies or plans.
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29. Besarab, A. 2000 ; Semin. Nephrol. 20, 364374. 30. Leist, M., Ghezzi, P., Grasso, G., Bianchi, R., Villa, P., Fratelli, M., Savino, C., Bianchi, M., Nielsen, J., Gerwien, J., et al. 2004 ; Science 305, 239242. 31. Grasso, G., Sfacteria, A., Cerami, A. & Brines, M. 2004 ; Neuroscientist 10, 9398. 32. Schnell, L., Fearn, S., Klassen, H., Schwab, M. E. & Perry, V. H. 1999 ; Eur. J. Neurosci. 11, 36483658. 33. Liu, X. Z., Xu, X. M., Hu, R., Du, C., Zhang, S. X., McDonald, J. W., Dong, H. X., Wu, Y. J., Fan, G. S., Jacquin, M. F., et al. 1997 ; J. Neurosci. 17, 53955406. 34. Shuman, S. L., Bresnahan, J. C. & Beattie, M. S. 1997 ; J. Neurosci. Res. 50, 798808. 35. Merrill, J. E. & Benveniste, E. N. 1996 ; Trends Neurosci. 19, 331338. 36. Yang, L., Jones, N. R., Blumbergs, P. C., Van Den Heuvel, C., Moore, E. J., Manavis, J., Sarvestani, G. T. & Ghabriel, M. N. 2005 ; J. Clin. Neurosci. 12, 276284. 37. Yang, L., Blumbergs, P. C., Jones, N. R., Manavis, J., Sarvestani, G. T. & Ghabriel, M. N. 2004 ; Spine 29, 966971. 38. Pan, J. Z., Ni, L., Sodhi, A., Aguanno, A., Young, W. & Hart, R. P. 2002 ; J. Neurosci. Res. 68, 315322. 39. Fu, E. S. & Saporta, S. 2005 ; J. Neurosurg. Anesthesiol. 17, 8285. 40. Lacroix, S., Chang, L., Rose-John, S. & Tuszynski, M. H. 2002 ; J. Comp. Neurol. 454, 213228. 41. Okada, S., Nakamura, M., Mikami, Y., Shimazaki, T., Mihara, M., Ohsugi, Y., Iwamoto, Y., Yoshizaki, K., Kishimoto, T., Toyama, Y. & Okano, H. 2004 ; J. Neurosci. Res. 76, 265276. 42. Pannu, R., Barbosa, E., Singh, A. K. & Singh, I. 2005 ; J. Neurosci. Res. 79, 340350. 43. Hirose, K., Okajima, K., Uchiba, M., Nakano, K. Y., Utoh, J. & Kitamura, N. 2004 ; Thromb. Haemost. 91, 162170. 44. Mautes, A. E., Weinzierl, M. R., Donovan, F. & Noble, L. J. 2000 ; Phys. Ther. 80, 673687. 45. Noble, L. J., Donovan, F., Igarashi, T., Goussev, S. & Werb, Z. 2002 ; J. Neurosci. 22, 75267535. 46. Springborg, J. B., Ma, X., Rochat, P., Knudsen, G. M., Amtorp, O., Paulson, O. B., Juhler, M. & Olsen, N. V. 2002 ; Br. J. Pharmacol. 135, 823829. 47. Grasso, G., Buemi, M., Alafaci, C., Sfacteria, A., Passalacqua, M., Sturiale, A., Calapai, G., De Vico, G., Piedimonte, G., Salpietro, F. M. & Tomasello, F. 2002 ; Proc. Natl. Acad. Sci. USA 99, 56275631. 48. Yang, S. & Zhang, L. 2004 ; Curr. Vasc. Pharmacol. 2, 112. 49. Iuchi, T., Akaike, M., Mitsui, T., Ohshima, Y., Shintani, Y., Azuma, H. & Matsumoto, T. 2003 ; Circ. Res. 92, 8187. 50. Mitchell, B. M., Dorrance, A. M., Mack, E. A. & Webb, R. C. 2004 ; J. Cardiovasc. Pharmacol. 43, 813. 51. Erbayraktar, S., Grasso, G., Sfacteria, A., Xie, Q. W., Coleman, T., Kreilgaard, M., Torup, L., Sager, T., Erbayraktar, Z., Gokmen, N., et al. 2003 ; Proc. Natl. Acad. Sci. USA 100, 67416746. 52. Brown, M. R. & Fisher, L. A. 1986 ; Life Sci. 39, 10031012. 53. Elenkov, I. J. & Chrousos, G. P. 2002 ; Ann. N.Y. Acad. Sci. 966, 290303. 54. Woiciechowsky, C., Asadullah, K., Nestler, D., Eberhardt, B., Platzer, C., Schoning, B., Glockner, F., Lanksch, W. R., Volk, H. D. & Docke, W. D. 1998 ; Nat. Med. 4, 808813. 55. Hayashi, M., Ueyama, T., Nemoto, K., Tamaki, T. & Senba, E. 2000 ; J. Neurotrauma 17, 203218. 56. Viviani, B., Bartesaghi, S., Corsini, E., Villa, P., Ghezzi, P., Garau, A., Galli, C. L. & Marinovich, M. 2005 ; J. Neurochem. 93, 412421.
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Injury. The claimant sustained a lumbar strain. The majority of the treating physicians diagnosed the claimant as having a lumbar strain. The Majority's failure to identify that the claimant sustained any injury is contrary to every medical opinion and therefore arbitrary. It is evident that the claimant sustained a compensable injury in the form of a lumbar strain. While the claimant admittedly had few objective findings, the fact remains that he sustained a minor injury in the form of a strain. The existence of a lumbar strain is evidenced by objective medical findings and medical opinions of several treating physicians. The claimant was repeatedly tested to make sure that his complaints were valid, and every doctor concluded that the claimant had a legitimate injury with symptoms. Additionally, the claimant had no recent prior history of back pain, and after the accident there is no indication that his symptoms ever resolved or that he had exited his healing period. In fact, Dr. Holder had just noted that the claimant had not reached MMI when the respondents terminated his medical treatment. Furthermore.
Coatings Although China is expected to become the largest coating market in Asia statistics show that China needs 2-3 million tonnes of coating material annually ; , tough market competition has forced down coating prices below normal standards. Despite strong demand, currently growing at an annual rate of 25%, the average price for coatings in China decreased in the first half of 2004, mainly due to fierce competition between multinationals and local small and mid-sized enterprises. Feed additives The output of feed additives in China had already reached 1.8 million tonnes in 2003. Although China has become a significantly large country in terms of feed production, the average annual feed possession per capita is only 50% of the average international level. According to the development plan of the feed industry, the output of mixed feed in China is expected to reach over 100 million tonnes in 2010, therefore there will be a rather significant increase in the demand for feed additives. 18 Based on the present supply of feed additives, China will emphasize the development of products with limited supply, or those without production capacity, such as methionine and threonine. At the same time, China will develop new types of additives to replace those products that are no longer used in advanced countries. Food additives The total output of food additives in China was over 2.2 million tonnes in 2003, and production value exceeded RMB 20 billion. 19 Compared to advanced countries, the food industry in China has great potential for development. Especially with the improvement of people's living standard and increasing population, the demand for processed food has been continuously increasing. According to the development plan of the food industry, it is projected that the production value of the food industry will reach around RMB 2, 000 billion in 2010, needing 2.83.0 million tonnes of supporting food additives. 20 The emphasis on future development will be placed on the food additives used in convenient and special nutrient food. Adhesives China is a main producer and consumer of adhesives globally, and the output of adhesives reached 3.35 million tonnes in 2003. With the development of the domestic industries such as construction, wood processing, packing, and shoe making, synthetic adhesives will continue to grow at a high speed. It is projected that China's demand for synthetic adhesives will reach 4.8-5.0 million tonnes in 2010. 21 The emphasis on development includes ureaformaldehyde adhesives with low formaldehyde release, widening the scope of application for polyurethane adhesives, high performance building sealants, adhesives used in electronic industry, adhesives used in automobile industry, environmentally friendly hot-melt adhesives and other non-solvent adhesives, and gradually washing out neoprene which is used in shoe making as well as 107 adhesives used in construction. Electronic chemicals Electronic information products have been listed as a key development pillar industry of the Chinese economy. It is projected that the industrial production value in China will be over RMB 1, 500 billion in 2005. As supporting materials for the electronic industry, market scale of electronic chemicals in China will exceed RMB 26 billion by 2010 22 . However, because of the late start in the domestic production of electronic chemicals, and the low level of scientific research development, imported products can occupy around 50% of the total market value, and this is incompatible with common perception of China's relatively important position in the global electronic information industry. In order to satisfy the need for the development of China's electronic industry, the emphasis of development of electronic chemicals in recent years includes epoxy resins used in printed circuit board PCB ; , dry film resists, and new type of electronic packaging materials.
The number of Medical Reserve Corps MRC ; units in Connecticut continues to grow. In April of this year, there were four MRC units; there are now six and two more are in the process of being approved. Volunteers can play an important role in supporting hospitals during a large-scale disaster. Whether licensed healthcare professionals, non-licensed healthcare support staff or concerned individuals from the community, all have skills, capabilities and a desire to help that can be translated into substantial medical response capacity. To enroll in the MRC, please visit : ynh-mrc . For questions or concerns, please contact the MRC Coordinator Eugenie Schwartz at 203 ; 688-2659 or eugenie hwartz ynhh.
The prescriber's name, address and telephone number. This will allow either the patient or the dispenser to contact the prescriber for any clarification or potential problem with the prescription. Date of the prescription. In many countries the validity of a prescription has no time limit, but in some countries pharmacists do not dispense drugs on prescriptions older than 3 to 6 months. Name, form and strength of the drug. The International Nonproprietary Name of the drug should always be used. If there is a specific reason to prescribe a special brand, the trade name can be added. Generic substitution is allowed in some countries. The pharmaceutical form for example `tablet', `oral solution', `eye ointment' ; should also be stated. The strength of the drug should be stated in standard units using ` abbreviations that are consistent with the Systeme Internationale SI ; . `Microgram' and `nanogram' should not, however, be abbreviated. Also, `units' should not be abbreviated. Avoid decimals whenever possible. If unavoidable, a zero should be written in front of the decimal point. Specific areas for filling in details about the patient including name, address and age, for example, ocumeter.
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GH Werstuck Department of Biochemistry and Biomedical Sciences, McMaster University and the Henderson Research Centre, Hamilton, Ontario Diabetes mellitus is a major independent risk factor for cardiovascular disease and stroke, however, the molecular and cellular mechanisms by which diabetes contributes to the development of vascular disease are not fully understood. It is well-established that hyperglycemia promotes intracellular glucose flux through the hexosamine pathway leading to the production of glucosamine-6-phosphate. This process has been implicated in several diabetes-associated complications including insulin resistance, pancreatic cell death and atherosclerosis. Intracellular glucosamine can also disrupt cellular function by interfering with protein folding in the endoplasmic reticulum ER ; . We hypothesize that the accumulation of intracellular glucosamine observed in diabetes may promote atherogenesis via a mechanism that involves ER dysfunction. In support of this theory, we have demonstrated that high concentrations of glucose, as well as glucosamine, cause ER dysfunction in cell types relevant to the development of atherosclerosis, including human aortic smooth muscle cells, endothelial cells, monocytes, macrophages and hepatocytes. Furthermore, we have shown that glucosamine-induced ER dysfunction can promote lipid accumulation, activate inflammatory pathways and cause apoptosis the hallmark features of atherosclerosis. In aortae of STZ-induced diabetic mice, we have observed a correlation between elevated intracellular glucosamine, ER stress and accelerated atherosclerosis. To determine the physiological relevance of this model, we have begun to measure diagnostic markers of ER stress in blood samples from diabetic and non-diabetic patients. This novel mechanism may explain how diabetes and hyperglycemia promote atherosclerosis and provides potential targets for therapeutic intervention.
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